diff --git a/Cargo.lock b/Cargo.lock
index 38514a3..4f8776d 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -1468,9 +1468,9 @@ checksum = "b9e0384b61958566e926dc50660321d12159025e767c18e043daf26b70104c39"
 
 [[package]]
 name = "indexmap"
-version = "2.4.0"
+version = "2.5.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "93ead53efc7ea8ed3cfb0c79fc8023fbb782a5432b52830b6518941cebe6505c"
+checksum = "68b900aa2f7301e21c36462b170ee99994de34dff39a4a6a528e80e7376d07e5"
 dependencies = [
  "equivalent",
  "hashbrown",
@@ -1611,6 +1611,7 @@ dependencies = [
  "anyhow",
  "chrono",
  "futures",
+ "indexmap",
  "lact-schema",
  "libdrm_amdgpu_sys",
  "libflate",
diff --git a/Cargo.toml b/Cargo.toml
index df20b6a..c4da4ad 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -23,6 +23,7 @@ futures = { version = "0.3.30", default-features = false }
 tokio = { version = "1.35.1", default-features = false }
 nix = { version = "0.29.0", default-features = false }
 chrono = "0.4.31"
+indexmap = { version = "2.5.0", features = ["serde"] }
 
 [profile.release]
 strip = "symbols"
diff --git a/lact-client/src/lib.rs b/lact-client/src/lib.rs
index 4c65a99..702c39b 100644
--- a/lact-client/src/lib.rs
+++ b/lact-client/src/lib.rs
@@ -3,6 +3,7 @@ mod connection;
 mod macros;
 
 pub use lact_schema as schema;
+use lact_schema::request::ProfileBase;
 
 use amdgpu_sysfs::gpu_handle::{
     power_profile_mode::PowerProfileModesTable, PerformanceLevel, PowerLevelKind,
@@ -12,8 +13,8 @@ use connection::{tcp::TcpConnection, unix::UnixConnection, DaemonConnection};
 use nix::unistd::getuid;
 use schema::{
     request::{ConfirmCommand, SetClocksCommand},
-    ClocksInfo, DeviceInfo, DeviceListEntry, DeviceStats, FanOptions, PowerStates, Request,
-    Response, SystemInfo,
+    ClocksInfo, DeviceInfo, DeviceListEntry, DeviceStats, FanOptions, PowerStates, ProfilesInfo,
+    Request, Response, SystemInfo,
 };
 use serde::Deserialize;
 use std::{
@@ -116,6 +117,7 @@ impl DaemonClient {
     request_plain!(disable_overdrive, DisableOverdrive, String);
     request_plain!(generate_debug_snapshot, GenerateSnapshot, String);
     request_plain!(reset_config, RestConfig, ());
+    request_plain!(list_profiles, ListProfiles, ProfilesInfo);
     request_with_id!(get_device_info, DeviceInfo, DeviceInfo);
     request_with_id!(get_device_stats, DeviceStats, DeviceStats);
     request_with_id!(get_device_clocks_info, DeviceClocksInfo, ClocksInfo);
@@ -128,6 +130,24 @@ impl DaemonClient {
     request_with_id!(reset_pmfw, ResetPmfw, u64);
     request_with_id!(dump_vbios, VbiosDump, Vec<u8>);
 
+    pub async fn set_profile(&self, name: Option<String>) -> anyhow::Result<()> {
+        self.make_request(Request::SetProfile { name })
+            .await?
+            .inner()
+    }
+
+    pub async fn create_profile(&self, name: String, base: ProfileBase) -> anyhow::Result<()> {
+        self.make_request(Request::CreateProfile { name, base })
+            .await?
+            .inner()
+    }
+
+    pub async fn delete_profile(&self, name: String) -> anyhow::Result<()> {
+        self.make_request(Request::DeleteProfile { name })
+            .await?
+            .inner()
+    }
+
     pub async fn set_performance_level(
         &self,
         id: &str,
diff --git a/lact-daemon/Cargo.toml b/lact-daemon/Cargo.toml
index 34593bf..c7f808a 100644
--- a/lact-daemon/Cargo.toml
+++ b/lact-daemon/Cargo.toml
@@ -27,6 +27,7 @@ tokio = { workspace = true, features = [
     "sync",
 ] }
 futures = { workspace = true }
+indexmap = { workspace = true }
 
 pciid-parser = { version = "0.7", features = ["serde"] }
 serde_yaml = "0.9"
diff --git a/lact-daemon/src/config.rs b/lact-daemon/src/config.rs
index b4e8efc..c90f203 100644
--- a/lact-daemon/src/config.rs
+++ b/lact-daemon/src/config.rs
@@ -1,6 +1,7 @@
 use crate::server::gpu_controller::fan_control::FanCurve;
 use amdgpu_sysfs::gpu_handle::{PerformanceLevel, PowerLevelKind};
 use anyhow::Context;
+use indexmap::IndexMap;
 use lact_schema::{default_fan_curve, request::SetClocksCommand, FanControlMode, PmfwOptions};
 use nix::unistd::getuid;
 use notify::{RecommendedWatcher, Watcher};
@@ -27,7 +28,11 @@ pub struct Config {
     #[serde(default = "default_apply_settings_timer")]
     pub apply_settings_timer: u64,
     #[serde(default, skip_serializing_if = "HashMap::is_empty")]
-    pub gpus: HashMap<String, Gpu>,
+    gpus: HashMap<String, Gpu>,
+    #[serde(default, skip_serializing_if = "IndexMap::is_empty")]
+    pub profiles: IndexMap<String, Profile>,
+    #[serde(default)]
+    pub current_profile: Option<String>,
 }
 
 impl Default for Config {
@@ -36,6 +41,8 @@ impl Default for Config {
             daemon: Daemon::default(),
             apply_settings_timer: default_apply_settings_timer(),
             gpus: HashMap::new(),
+            profiles: IndexMap::new(),
+            current_profile: None,
         }
     }
 }
@@ -61,6 +68,12 @@ impl Default for Daemon {
     }
 }
 
+#[derive(Debug, Clone, Serialize, Deserialize, Default, PartialEq)]
+pub struct Profile {
+    #[serde(default, skip_serializing_if = "HashMap::is_empty")]
+    pub gpus: HashMap<String, Gpu>,
+}
+
 #[skip_serializing_none]
 #[derive(Debug, Clone, Serialize, Deserialize, Default, PartialEq)]
 pub struct Gpu {
@@ -178,6 +191,54 @@ impl Config {
             Ok(config)
         }
     }
+
+    /// Gets the GPU configs according to the current profile. Returns an error if the current profile could not be found.
+    pub fn gpus(&self) -> anyhow::Result<&HashMap<String, Gpu>> {
+        match &self.current_profile {
+            Some(profile) => {
+                let profile = self
+                    .profiles
+                    .get(profile)
+                    .with_context(|| format!("Could not find profile '{profile}'"))?;
+                Ok(&profile.gpus)
+            }
+            None => Ok(&self.gpus),
+        }
+    }
+
+    /// Same as [`gpus`], but with a mutable reference
+    pub fn gpus_mut(&mut self) -> anyhow::Result<&mut HashMap<String, Gpu>> {
+        match &self.current_profile {
+            Some(profile) => {
+                let profile = self
+                    .profiles
+                    .get_mut(profile)
+                    .with_context(|| format!("Could not find profile '{profile}'"))?;
+                Ok(&mut profile.gpus)
+            }
+            None => Ok(&mut self.gpus),
+        }
+    }
+
+    /// Get a specific profile
+    pub fn profile(&self, profile: &str) -> anyhow::Result<&Profile> {
+        self.profiles
+            .get(profile)
+            .with_context(|| format!("Profile {profile} not found"))
+    }
+
+    /// Get the settings for "default" profile (aka no profile)
+    pub fn default_profile(&self) -> Profile {
+        Profile {
+            gpus: self.gpus.clone(),
+        }
+    }
+
+    pub fn clear(&mut self) {
+        self.gpus.clear();
+        self.profiles.clear();
+        self.current_profile = None;
+    }
 }
 
 pub fn start_watcher(config_last_saved: Arc<Mutex<Instant>>) -> mpsc::UnboundedReceiver<Config> {
diff --git a/lact-daemon/src/lib.rs b/lact-daemon/src/lib.rs
index 5048328..8f73c41 100644
--- a/lact-daemon/src/lib.rs
+++ b/lact-daemon/src/lib.rs
@@ -18,7 +18,7 @@ use tokio::{
     signal::unix::{signal, SignalKind},
     task::LocalSet,
 };
-use tracing::{debug, debug_span, info, warn, Instrument, Level};
+use tracing::{debug, debug_span, error, info, warn, Instrument, Level};
 
 /// RDNA3, minimum family that supports the new pmfw interface
 pub const AMDGPU_FAMILY_GC_11_0_0: u32 = 145;
@@ -109,8 +109,14 @@ async fn listen_config_changes(handler: Handler) {
     while let Some(new_config) = rx.recv().await {
         info!("config file was changed, reloading");
         handler.config.replace(new_config);
-        handler.apply_current_config().await;
-        info!("configuration reloaded");
+        match handler.apply_current_config().await {
+            Ok(()) => {
+                info!("configuration reloaded");
+            }
+            Err(err) => {
+                error!("could not apply new config: {err:#}");
+            }
+        }
     }
 }
 
diff --git a/lact-daemon/src/server/mod.rs b/lact-daemon/src/server.rs
similarity index 95%
rename from lact-daemon/src/server/mod.rs
rename to lact-daemon/src/server.rs
index a450056..7668f81 100644
--- a/lact-daemon/src/server/mod.rs
+++ b/lact-daemon/src/server.rs
@@ -164,6 +164,10 @@ async fn handle_request<'a>(request: Request<'a>, handler: &'a Handler) -> anyho
             ok_response(handler.set_enabled_power_states(id, kind, states).await?)
         }
         Request::VbiosDump { id } => ok_response(handler.vbios_dump(id)?),
+        Request::ListProfiles => ok_response(handler.list_profiles()),
+        Request::SetProfile { name } => ok_response(handler.set_profile(name).await?),
+        Request::CreateProfile { name, base } => ok_response(handler.create_profile(name, base)?),
+        Request::DeleteProfile { name } => ok_response(handler.delete_profile(name).await?),
         Request::EnableOverdrive => ok_response(system::enable_overdrive().await?),
         Request::DisableOverdrive => ok_response(system::disable_overdrive().await?),
         Request::GenerateSnapshot => ok_response(handler.generate_snapshot().await?),
diff --git a/lact-daemon/src/server/handler.rs b/lact-daemon/src/server/handler.rs
index d5f0b60..0ce2525 100644
--- a/lact-daemon/src/server/handler.rs
+++ b/lact-daemon/src/server/handler.rs
@@ -2,17 +2,17 @@ use super::{
     gpu_controller::{fan_control::FanCurve, GpuController},
     system::{self, detect_initramfs_type, PP_FEATURE_MASK_PATH},
 };
-use crate::config::{self, default_fan_static_speed, Config, FanControlSettings};
+use crate::config::{self, default_fan_static_speed, Config, FanControlSettings, Profile};
 use amdgpu_sysfs::{
     gpu_handle::{power_profile_mode::PowerProfileModesTable, PerformanceLevel, PowerLevelKind},
     sysfs::SysFS,
 };
-use anyhow::{anyhow, Context};
+use anyhow::{anyhow, bail, Context};
 use lact_schema::{
     default_fan_curve,
-    request::{ConfirmCommand, SetClocksCommand},
+    request::{ConfirmCommand, ProfileBase, SetClocksCommand},
     ClocksInfo, DeviceInfo, DeviceListEntry, DeviceStats, FanControlMode, FanOptions, PmfwOptions,
-    PowerStates,
+    PowerStates, ProfilesInfo,
 };
 use libflate::gzip;
 use nix::libc;
@@ -135,7 +135,9 @@ impl<'a> Handler {
             confirm_config_tx: Rc::new(RefCell::new(None)),
             config_last_saved: Arc::new(Mutex::new(Instant::now())),
         };
-        handler.apply_current_config().await;
+        if let Err(err) = handler.apply_current_config().await {
+            error!("could not apply config: {err:#}");
+        }
 
         // Eagerly release memory
         // `load_controllers` allocates and deallocates the entire PCI ID database,
@@ -148,10 +150,11 @@ impl<'a> Handler {
         Ok(handler)
     }
 
-    pub async fn apply_current_config(&self) {
+    pub async fn apply_current_config(&self) -> anyhow::Result<()> {
         let config = self.config.borrow().clone(); // Clone to avoid locking the RwLock on an await point
 
-        for (id, gpu_config) in &config.gpus {
+        let gpus = config.gpus()?;
+        for (id, gpu_config) in gpus {
             if let Some(controller) = self.gpu_controllers.get(id) {
                 if let Err(err) = controller.apply_config(gpu_config).await {
                     error!("could not apply existing config for gpu {id}: {err}");
@@ -160,6 +163,8 @@ impl<'a> Handler {
                 info!("could not find GPU with id {id} defined in configuration");
             }
         }
+
+        Ok(())
     }
 
     async fn edit_gpu_config<F: FnOnce(&mut config::Gpu)>(
@@ -181,7 +186,7 @@ impl<'a> Handler {
         let (gpu_config, apply_timer) = {
             let config = self.config.try_borrow().map_err(|err| anyhow!("{err}"))?;
             let apply_timer = config.apply_settings_timer;
-            let gpu_config = config.gpus.get(&id).cloned().unwrap_or_default();
+            let gpu_config = config.gpus()?.get(&id).cloned().unwrap_or_default();
             (gpu_config, apply_timer)
         };
 
@@ -243,7 +248,12 @@ impl<'a> Handler {
                             *handler.config_last_saved.lock().unwrap() = Instant::now();
 
                             let mut config_guard = handler.config.borrow_mut();
-                            config_guard.gpus.insert(id, new_config);
+                            match config_guard.gpus_mut() {
+                                Ok(gpus) => {
+                                    gpus.insert(id, new_config);
+                                }
+                                Err(err) => error!("{err:#}"),
+                            }
 
                             if let Err(err) = config_guard.save() {
                                 error!("{err:#}");
@@ -302,7 +312,7 @@ impl<'a> Handler {
             .config
             .try_borrow()
             .map_err(|err| anyhow!("Could not read config: {err:?}"))?;
-        let gpu_config = config.gpus.get(id);
+        let gpu_config = config.gpus()?.get(id);
         Ok(self.controller_by_id(id)?.get_stats(gpu_config))
     }
 
@@ -316,7 +326,10 @@ impl<'a> Handler {
                 .config
                 .try_borrow_mut()
                 .map_err(|err| anyhow!("{err}"))?;
-            let gpu_config = config_guard.gpus.entry(opts.id.to_owned()).or_default();
+            let gpu_config = config_guard
+                .gpus_mut()?
+                .entry(opts.id.to_owned())
+                .or_default();
 
             match opts.mode {
                 Some(mode) => match mode {
@@ -412,7 +425,7 @@ impl<'a> Handler {
             .config
             .try_borrow()
             .map_err(|err| anyhow!("Could not read config: {err:?}"))?;
-        let gpu_config = config.gpus.get(id);
+        let gpu_config = config.gpus()?.get(id);
 
         let states = self.controller_by_id(id)?.get_power_states(gpu_config);
         Ok(states)
@@ -593,6 +606,53 @@ impl<'a> Handler {
         Ok(out_path)
     }
 
+    pub fn list_profiles(&self) -> ProfilesInfo {
+        let config = self.config.borrow();
+        ProfilesInfo {
+            profiles: config.profiles.keys().cloned().collect(),
+            current_profile: config.current_profile.clone(),
+        }
+    }
+
+    pub async fn set_profile(&self, name: Option<String>) -> anyhow::Result<()> {
+        if let Some(name) = &name {
+            self.config.borrow().profile(name)?;
+        }
+
+        self.cleanup().await;
+        self.config.borrow_mut().current_profile = name;
+
+        self.apply_current_config().await?;
+        self.config.borrow_mut().save()?;
+
+        Ok(())
+    }
+
+    pub fn create_profile(&self, name: String, base: ProfileBase) -> anyhow::Result<()> {
+        let mut config = self.config.borrow_mut();
+        if config.profiles.contains_key(&name) {
+            bail!("Profile {name} already exists");
+        }
+
+        let profile = match base {
+            ProfileBase::Empty => Profile::default(),
+            ProfileBase::Default => config.default_profile(),
+            ProfileBase::Profile(name) => config.profile(&name)?.clone(),
+        };
+        config.profiles.insert(name, profile);
+        config.save()?;
+        Ok(())
+    }
+
+    pub async fn delete_profile(&self, name: String) -> anyhow::Result<()> {
+        if self.config.borrow().current_profile.as_ref() == Some(&name) {
+            self.set_profile(None).await?;
+        }
+        self.config.borrow_mut().profiles.shift_remove(&name);
+        self.config.borrow().save()?;
+        Ok(())
+    }
+
     pub fn confirm_pending_config(&self, command: ConfirmCommand) -> anyhow::Result<()> {
         if let Some(tx) = self
             .confirm_config_tx
@@ -611,7 +671,7 @@ impl<'a> Handler {
         self.cleanup().await;
 
         let mut config = self.config.borrow_mut();
-        config.gpus.clear();
+        config.clear();
 
         *self.config_last_saved.lock().unwrap() = Instant::now();
         if let Err(err) = config.save() {
diff --git a/lact-daemon/src/suspend.rs b/lact-daemon/src/suspend.rs
index 208aabd..8727480 100644
--- a/lact-daemon/src/suspend.rs
+++ b/lact-daemon/src/suspend.rs
@@ -10,7 +10,9 @@ pub async fn listen_events(handler: Handler) {
             Ok(mut stream) => {
                 while stream.next().await.is_some() {
                     info!("suspend/resume event detected, reloading config");
-                    handler.apply_current_config().await;
+                    if let Err(err) = handler.apply_current_config().await {
+                        error!("could not reapply config: {err:#}");
+                    }
                 }
             }
             Err(err) => error!("could not subscribe to suspend events: {err:#}"),
diff --git a/lact-gui/src/app/mod.rs b/lact-gui/src/app.rs
similarity index 96%
rename from lact-gui/src/app/mod.rs
rename to lact-gui/src/app.rs
index b266921..3dfbe3b 100644
--- a/lact-gui/src/app/mod.rs
+++ b/lact-gui/src/app.rs
@@ -24,7 +24,7 @@ use gtk::{
     ApplicationWindow, ButtonsType, FileChooserAction, FileChooserDialog, MessageDialog,
     MessageType, ResponseType,
 };
-use header::Header;
+use header::{Header, HeaderMsg};
 use lact_client::DaemonClient;
 use lact_daemon::MODULE_CONF_PATH;
 use lact_schema::{
@@ -181,7 +181,7 @@ impl AsyncComponent for AppModel {
             show_embedded_info(&root, err);
         }
 
-        sender.input(AppMsg::ReloadData { full: true });
+        sender.input(AppMsg::ReloadProfiles);
 
         AsyncComponentParts { model, widgets }
     }
@@ -210,6 +210,11 @@ impl AppModel {
     ) -> Result<(), Rc<anyhow::Error>> {
         match msg {
             AppMsg::Error(err) => Err(err),
+            AppMsg::ReloadProfiles => {
+                self.reload_profiles().await?;
+                sender.input(AppMsg::ReloadData { full: false });
+                Ok(())
+            }
             AppMsg::ReloadData { full } => {
                 let gpu_id = self.current_gpu_id()?;
                 if full {
@@ -219,6 +224,24 @@ impl AppModel {
                 }
                 Ok(())
             }
+            AppMsg::SelectProfile(profile) => {
+                self.daemon_client.set_profile(profile).await?;
+                sender.input(AppMsg::ReloadData { full: false });
+                Ok(())
+            }
+            AppMsg::CreateProfile(name, base) => {
+                self.daemon_client
+                    .create_profile(name.clone(), base)
+                    .await?;
+                self.daemon_client.set_profile(Some(name)).await?;
+                sender.input(AppMsg::ReloadProfiles);
+                Ok(())
+            }
+            AppMsg::DeleteProfile(profile) => {
+                self.daemon_client.delete_profile(profile).await?;
+                sender.input(AppMsg::ReloadProfiles);
+                Ok(())
+            }
             AppMsg::Stats(stats) => {
                 self.root_stack.info_page.set_stats(&stats);
                 self.root_stack.thermals_page.set_stats(&stats, false);
@@ -308,6 +331,12 @@ impl AppModel {
             .context("No GPU selected")
     }
 
+    async fn reload_profiles(&mut self) -> anyhow::Result<()> {
+        let profiles = self.daemon_client.list_profiles().await?.inner()?;
+        self.header.emit(HeaderMsg::Profiles(profiles));
+        Ok(())
+    }
+
     async fn update_gpu_data_full(
         &mut self,
         gpu_id: String,
@@ -334,6 +363,8 @@ impl AppModel {
 
         self.root_stack.thermals_page.set_info(&info);
 
+        self.graphs_window.clear();
+
         Ok(())
     }
 
@@ -434,8 +465,6 @@ impl AppModel {
             .send(ApplyRevealerMsg::Hide)
             .unwrap();
 
-        self.graphs_window.clear();
-
         self.stats_task_handle = Some(start_stats_update_loop(
             gpu_id.to_owned(),
             self.daemon_client.clone(),
diff --git a/lact-gui/src/app/header.rs b/lact-gui/src/app/header.rs
index 48e7fb0..b7e4dc1 100644
--- a/lact-gui/src/app/header.rs
+++ b/lact-gui/src/app/header.rs
@@ -1,21 +1,39 @@
+mod new_profile_dialog;
+
 use super::{AppMsg, DebugSnapshot, DisableOverdrive, DumpVBios, ResetConfig, ShowGraphsWindow};
+use glib::clone;
 use gtk::prelude::*;
 use gtk::*;
 use lact_client::schema::DeviceListEntry;
+use lact_schema::ProfilesInfo;
+use new_profile_dialog::NewProfileDialog;
 use relm4::{
-    Component, ComponentController, ComponentParts, ComponentSender, Controller, SimpleComponent,
+    typed_view::list::{RelmListItem, TypedListView},
+    Component, ComponentController, ComponentParts, ComponentSender, RelmWidgetExt,
 };
-use relm4_components::simple_combo_box::SimpleComboBox;
+use std::fmt;
 
 pub struct Header {
-    gpu_selector: Controller<SimpleComboBox<DeviceListEntry>>,
+    gpu_selector: TypedListView<GpuListItem, gtk::SingleSelection>,
+    profile_selector: TypedListView<ProfileListItem, gtk::SingleSelection>,
+    selector_label: String,
+}
+
+#[derive(Debug)]
+pub enum HeaderMsg {
+    Profiles(ProfilesInfo),
+    SelectProfile,
+    SelectGpu,
+    CreateProfile,
+    DeleteProfile,
 }
 
 #[relm4::component(pub)]
-impl SimpleComponent for Header {
+impl Component for Header {
     type Init = (Vec<DeviceListEntry>, gtk::Stack);
-    type Input = ();
+    type Input = HeaderMsg;
     type Output = AppMsg;
+    type CommandOutput = ();
 
     view! {
         gtk::HeaderBar {
@@ -26,14 +44,80 @@ impl SimpleComponent for Header {
                 set_stack: Some(&stack),
             },
 
-            #[local_ref]
-            pack_start = gpu_selector -> ComboBoxText,
+            #[name = "menu_button"]
+            pack_start = &gtk::MenuButton {
+                #[watch]
+                set_label: &model.selector_label,
+                #[wrap(Some)]
+                set_popover = &gtk::Popover {
+                    set_margin_all: 5,
+                    set_autohide: false,
+
+                    gtk::Box {
+                        set_orientation: gtk::Orientation::Vertical,
+                        set_spacing: 5,
+
+                        gtk::Frame {
+                            set_label: Some("GPU"),
+                            set_label_align: 0.05,
+                            set_margin_all: 5,
+
+                            gtk::ScrolledWindow {
+                                set_policy: (gtk::PolicyType::Never, gtk::PolicyType::Automatic),
+                                set_propagate_natural_height: true,
+
+                                #[local_ref]
+                                gpu_selector -> gtk::ListView { }
+                            }
+                        },
+
+                        gtk::Frame {
+                            set_label: Some("Settings Profile"),
+                            set_label_align: 0.05,
+                            set_margin_all: 5,
+
+                            gtk::Box {
+                                set_orientation: gtk::Orientation::Vertical,
+                                set_spacing: 5,
+
+                                gtk::ScrolledWindow {
+                                    set_policy: (gtk::PolicyType::Never, gtk::PolicyType::Automatic),
+                                    set_propagate_natural_height: true,
+
+                                    #[local_ref]
+                                    profile_selector -> gtk::ListView { }
+                                },
+
+                                gtk::Box {
+                                    set_orientation: gtk::Orientation::Horizontal,
+                                    set_spacing: 5,
+
+                                    gtk::Button {
+                                        set_expand: true,
+                                        set_icon_name: "list-add-symbolic",
+                                        connect_clicked => HeaderMsg::CreateProfile,
+                                    },
+
+                                    gtk::Button {
+                                        set_expand: true,
+                                        set_icon_name: "list-remove-symbolic",
+                                        connect_clicked => HeaderMsg::DeleteProfile,
+                                        #[watch]
+                                        set_sensitive: model.profile_selector.selection_model.selected() != 0,
+                                    },
+                                }
+                            }
+                        },
+                    }
+                },
+            },
 
             pack_end = &gtk::MenuButton {
                 set_icon_name: "open-menu-symbolic",
                 set_menu_model: Some(&app_menu),
             }
-        }
+        },
+
     }
 
     menu! {
@@ -57,114 +141,225 @@ impl SimpleComponent for Header {
         root: Self::Root,
         sender: ComponentSender<Self>,
     ) -> ComponentParts<Self> {
-        let gpu_selector = SimpleComboBox::builder()
-            .launch(SimpleComboBox {
-                variants,
-                active_index: Some(0),
-            })
-            .forward(sender.output_sender(), |_| AppMsg::ReloadData {
-                full: true,
-            });
+        sender.input(HeaderMsg::SelectGpu);
 
-        // limits the length of gpu names in combobox
-        for cell in gpu_selector.widget().cells() {
-            cell.set_property("width-chars", 10);
-            cell.set_property("ellipsize", pango::EllipsizeMode::End);
-        }
+        let mut gpu_selector = TypedListView::<_, gtk::SingleSelection>::new();
+        gpu_selector.extend_from_iter(variants.into_iter().map(GpuListItem));
 
-        let model = Self { gpu_selector };
+        gpu_selector
+            .selection_model
+            .connect_selection_changed(clone!(
+                #[strong]
+                sender,
+                move |_, _, _| {
+                    sender.input(HeaderMsg::SelectGpu);
+                }
+            ));
 
-        let gpu_selector = model.gpu_selector.widget();
+        let profile_selector = TypedListView::<_, gtk::SingleSelection>::new();
+        profile_selector
+            .selection_model
+            .connect_selection_changed(clone!(
+                #[strong]
+                sender,
+                move |_, _, _| {
+                    sender.input(HeaderMsg::SelectProfile);
+                }
+            ));
+
+        let model = Self {
+            gpu_selector,
+            profile_selector,
+            selector_label: String::new(),
+        };
+
+        let gpu_selector = &model.gpu_selector.view;
+        let profile_selector = &model.profile_selector.view;
         let widgets = view_output!();
 
+        widgets.menu_button.connect_label_notify(|menu_button| {
+            let label_box = menu_button
+                .first_child()
+                .unwrap()
+                .downcast::<gtk::ToggleButton>()
+                .unwrap()
+                .child()
+                .unwrap()
+                .downcast::<gtk::Box>()
+                .unwrap();
+            // Limits the length of text in the menu button
+            let selector_label = label_box
+                .first_child()
+                .unwrap()
+                .downcast::<Label>()
+                .unwrap();
+            selector_label.set_ellipsize(pango::EllipsizeMode::End);
+            selector_label.set_width_chars(14);
+        });
+
         ComponentParts { model, widgets }
     }
+
+    fn update_with_view(
+        &mut self,
+        widgets: &mut Self::Widgets,
+        msg: Self::Input,
+        sender: ComponentSender<Self>,
+        _root: &Self::Root,
+    ) {
+        match msg {
+            HeaderMsg::Profiles(profiles_info) => {
+                let selected_index = match &profiles_info.current_profile {
+                    Some(profile) => {
+                        profiles_info
+                            .profiles
+                            .iter()
+                            .position(|value| value == profile)
+                            .expect("Active profile is not in the list")
+                            + 1
+                    }
+                    None => 0,
+                };
+
+                self.profile_selector.clear();
+                self.profile_selector.append(ProfileListItem::Default);
+
+                for profile in profiles_info.profiles {
+                    self.profile_selector
+                        .append(ProfileListItem::Profile(profile));
+                }
+
+                self.profile_selector
+                    .selection_model
+                    .set_selected(selected_index as u32);
+            }
+            HeaderMsg::SelectGpu => sender.output(AppMsg::ReloadData { full: true }).unwrap(),
+            HeaderMsg::SelectProfile => {
+                let selected_profile = self.selected_profile();
+                sender
+                    .output(AppMsg::SelectProfile(selected_profile))
+                    .unwrap();
+            }
+            HeaderMsg::CreateProfile => {
+                let mut diag_controller = NewProfileDialog::builder()
+                    .launch(self.custom_profiles())
+                    .forward(sender.output_sender(), |(name, base)| {
+                        AppMsg::CreateProfile(name, base)
+                    });
+                diag_controller.detach_runtime();
+            }
+            HeaderMsg::DeleteProfile => {
+                if let Some(selected_profile) = self.selected_profile() {
+                    let msg =
+                        format!("Are you sure you want to delete profile \"{selected_profile}\"");
+                    sender
+                        .output(AppMsg::ask_confirmation(
+                            AppMsg::DeleteProfile(selected_profile),
+                            "Delete profile",
+                            &msg,
+                            gtk::ButtonsType::OkCancel,
+                        ))
+                        .unwrap();
+                }
+            }
+        }
+        self.update_label();
+
+        self.update_view(widgets, sender);
+    }
 }
 
 impl Header {
     pub fn selected_gpu_id(&self) -> Option<String> {
+        let selected = self.gpu_selector.selection_model.selected();
         self.gpu_selector
-            .model()
-            .get_active_elem()
-            .map(|model| model.id.clone())
-    }
-}
-
-/*#[derive(Clone)]
-pub struct Header {
-    pub container: HeaderBar,
-    gpu_selector: ComboBoxText,
-    switcher: StackSwitcher,
-}
-
-impl Header {
-    pub fn new(system_info: &SystemInfo) -> Self {
-        let container = HeaderBar::new();
-        container.set_show_title_buttons(true);
-
-        let switcher = StackSwitcher::new();
-        container.set_title_widget(Some(&switcher));
-
-        let gpu_selector = ComboBoxText::new();
-        container.pack_start(&gpu_selector);
-
-        let menu = gio::Menu::new();
-        menu.append(
-            Some("Show historical charts"),
-            Some("app.show-graphs-window"),
-        );
-        menu.append(Some("Dump VBIOS"), Some("app.dump-vbios"));
-        menu.append(
-            Some("Generate debug snapshot"),
-            Some("app.generate-debug-snapshot"),
-        );
-
-        if system_info.amdgpu_overdrive_enabled == Some(true) {
-            menu.append(
-                Some("Disable overclocking support"),
-                Some("app.disable-overdrive"),
-            )
-        }
-
-        menu.append(Some("Reset all configuration"), Some("app.reset-config"));
-
-        let menu_button = MenuButton::builder()
-            .icon_name("open-menu-symbolic")
-            .menu_model(&menu)
-            .build();
-        container.pack_end(&menu_button);
-
-        Header {
-            container,
-            gpu_selector,
-            switcher,
-        }
+            .get(selected)
+            .as_ref()
+            .map(|item| item.borrow().0.id.clone())
     }
 
-    pub fn set_switcher_stack(&self, stack: &Stack) {
-        self.switcher.set_stack(Some(stack));
-    }
-
-    pub fn set_devices(&self, gpus: &[DeviceListEntry<'_>]) {
-        for (i, entry) in gpus.iter().enumerate() {
-            let name = format!("{i}: {}", entry.name.unwrap_or_default());
-            self.gpu_selector.append(Some(entry.id), &name);
-        }
-
-        //limits the length of gpu names in combobox
-        for cell in self.gpu_selector.cells() {
-            cell.set_property("width-chars", 10);
-            cell.set_property("ellipsize", EllipsizeMode::End);
-        }
-
-        self.gpu_selector.set_active(Some(0));
-    }
-
-    pub fn connect_gpu_selection_changed<F: Fn(String) + 'static>(&self, f: F) {
-        self.gpu_selector.connect_changed(move |gpu_selector| {
-            if let Some(selected_id) = gpu_selector.active_id() {
-                f(selected_id.to_string());
+    fn custom_profiles(&self) -> Vec<String> {
+        let mut profiles = Vec::with_capacity(self.profile_selector.len() as usize);
+        for i in 0..self.profile_selector.len() {
+            let item = self.profile_selector.get(i).unwrap();
+            let item = item.borrow();
+            if let ProfileListItem::Profile(name) = &*item {
+                profiles.push(name.clone());
             }
-        });
+        }
+        profiles
     }
-}*/
+
+    fn selected_profile(&self) -> Option<String> {
+        let selected_index = self.profile_selector.selection_model.selected();
+        let item = self
+            .profile_selector
+            .get(selected_index)
+            .expect("Invalid item selected");
+        let item = item.borrow().clone();
+        match item {
+            ProfileListItem::Default => None,
+            ProfileListItem::Profile(name) => Some(name),
+        }
+    }
+
+    fn update_label(&mut self) {
+        let gpu_index = self.gpu_selector.selection_model.selected();
+        let profile = self
+            .profile_selector
+            .get(self.profile_selector.selection_model.selected())
+            .as_ref()
+            .map(|item| item.borrow().to_string())
+            .unwrap_or_else(|| "<Unknown>".to_owned());
+
+        self.selector_label = format!("GPU {gpu_index} | {profile}");
+    }
+}
+
+struct GpuListItem(DeviceListEntry);
+
+impl RelmListItem for GpuListItem {
+    type Root = gtk::Label;
+    type Widgets = gtk::Label;
+
+    fn setup(_list_item: &gtk::ListItem) -> (Self::Root, Self::Widgets) {
+        let label = gtk::Label::new(None);
+        label.set_margin_all(5);
+        (label.clone(), label)
+    }
+
+    fn bind(&mut self, widgets: &mut Self::Widgets, _root: &mut Self::Root) {
+        widgets.set_label(self.0.name.as_deref().unwrap_or(&self.0.id));
+    }
+}
+
+#[derive(Clone)]
+enum ProfileListItem {
+    Default,
+    Profile(String),
+}
+
+impl fmt::Display for ProfileListItem {
+    fn fmt(&self, f: &mut fmt::Formatter<'_>) -> fmt::Result {
+        let text = match self {
+            ProfileListItem::Default => "Default",
+            ProfileListItem::Profile(name) => name,
+        };
+        text.fmt(f)
+    }
+}
+
+impl RelmListItem for ProfileListItem {
+    type Root = Label;
+    type Widgets = Label;
+
+    fn setup(_list_item: &gtk::ListItem) -> (Self::Root, Self::Widgets) {
+        let label = gtk::Label::new(None);
+        label.set_margin_all(5);
+        (label.clone(), label)
+    }
+
+    fn bind(&mut self, widgets: &mut Self::Widgets, _root: &mut Self::Root) {
+        widgets.set_label(&self.to_string());
+    }
+}
diff --git a/lact-gui/src/app/header/new_profile_dialog.rs b/lact-gui/src/app/header/new_profile_dialog.rs
new file mode 100644
index 0000000..b592a14
--- /dev/null
+++ b/lact-gui/src/app/header/new_profile_dialog.rs
@@ -0,0 +1,129 @@
+use gtk::prelude::*;
+use lact_schema::request::ProfileBase;
+use relm4::{
+    Component, ComponentController, ComponentParts, ComponentSender, Controller, RelmWidgetExt,
+};
+use relm4_components::simple_combo_box::SimpleComboBox;
+
+pub struct NewProfileDialog {
+    name_buffer: gtk::EntryBuffer,
+    base_selector: Controller<SimpleComboBox<ProfileBase>>,
+}
+
+#[derive(Debug)]
+pub enum NewProfileDialogMsg {
+    Create,
+}
+
+#[relm4::component(pub)]
+impl Component for NewProfileDialog {
+    type Init = Vec<String>;
+    type Input = NewProfileDialogMsg;
+    type Output = (String, ProfileBase);
+    type CommandOutput = ();
+
+    view! {
+        gtk::Window {
+            set_default_size: (250, 130),
+            set_title: Some("Create Profile"),
+            set_hide_on_close: true,
+
+            gtk::Box {
+                set_orientation: gtk::Orientation::Vertical,
+                set_spacing: 5,
+                set_margin_all: 10,
+
+                gtk::Entry {
+                    set_placeholder_text: Some("Name"),
+                    set_buffer: &model.name_buffer,
+                },
+
+                gtk::Box {
+                    set_orientation: gtk::Orientation::Horizontal,
+                    set_spacing: 5,
+
+                    gtk::Label {
+                        set_label: "Base profile:",
+                    },
+
+                    #[local_ref]
+                    base_selector -> gtk::ComboBoxText {
+                        set_margin_horizontal: 5,
+                        set_hexpand: true,
+                        set_halign: gtk::Align::End,
+                    },
+                },
+
+                gtk::Box {
+                    set_orientation: gtk::Orientation::Horizontal,
+                    set_spacing: 5,
+                    set_hexpand: true,
+                    set_vexpand: true,
+                    set_valign: gtk::Align::End,
+
+                    gtk::Button {
+                        set_label: "Cancel",
+                        set_hexpand: true,
+
+                        connect_clicked[root] => move |_| {
+                            root.hide();
+                        },
+                    },
+
+                    gtk::Button {
+                        set_label: "Create",
+                        set_hexpand: true,
+
+                        connect_clicked => NewProfileDialogMsg::Create,
+                    },
+                }
+            },
+        }
+    }
+
+    fn init(
+        current_profiles: Self::Init,
+        root: Self::Root,
+        sender: ComponentSender<Self>,
+    ) -> ComponentParts<Self> {
+        let mut variants = vec![ProfileBase::Empty, ProfileBase::Default];
+        variants.extend(current_profiles.into_iter().map(ProfileBase::Profile));
+
+        let base_selector = SimpleComboBox::<ProfileBase>::builder()
+            .launch(SimpleComboBox {
+                variants,
+                active_index: Some(1),
+            })
+            .detach();
+
+        let model = Self {
+            base_selector,
+            name_buffer: gtk::EntryBuffer::default(),
+        };
+
+        let base_selector = model.base_selector.widget();
+
+        let widgets = view_output!();
+
+        root.present();
+
+        ComponentParts { model, widgets }
+    }
+
+    fn update(&mut self, msg: Self::Input, sender: ComponentSender<Self>, root: &Self::Root) {
+        match msg {
+            NewProfileDialogMsg::Create => {
+                if self.name_buffer.length() != 0 {
+                    if let Some(selected) = self.base_selector.model().active_index {
+                        let base = self.base_selector.model().variants[selected].clone();
+                        sender
+                            .output((self.name_buffer.text().to_string(), base))
+                            .unwrap();
+
+                        root.hide();
+                    }
+                }
+            }
+        }
+    }
+}
diff --git a/lact-gui/src/app/msg.rs b/lact-gui/src/app/msg.rs
index dc44893..460ce89 100644
--- a/lact-gui/src/app/msg.rs
+++ b/lact-gui/src/app/msg.rs
@@ -1,5 +1,5 @@
 use super::confirmation_dialog::ConfirmationOptions;
-use lact_schema::DeviceStats;
+use lact_schema::{request::ProfileBase, DeviceStats};
 use std::rc::Rc;
 
 #[derive(Debug, Clone)]
@@ -17,6 +17,10 @@ pub enum AppMsg {
     EnableOverdrive,
     DisableOverdrive,
     ResetConfig,
+    ReloadProfiles,
+    SelectProfile(Option<String>),
+    CreateProfile(String, ProfileBase),
+    DeleteProfile(String),
     AskConfirmation(ConfirmationOptions, Box<AppMsg>),
 }
 
diff --git a/lact-schema/Cargo.toml b/lact-schema/Cargo.toml
index 57edd7f..f01af97 100644
--- a/lact-schema/Cargo.toml
+++ b/lact-schema/Cargo.toml
@@ -10,10 +10,10 @@ args = ["clap"]
 amdgpu-sysfs = { workspace = true }
 serde = { workspace = true }
 serde_with = { workspace = true }
-serde-error = "=0.1.2"
 anyhow = { workspace = true }
+indexmap = { workspace = true }
 
-indexmap = { version = "*", features = ["serde"] }
+serde-error = "=0.1.2"
 clap = { version = "4.4.18", features = ["derive"], optional = true }
 
 [build-dependencies]
diff --git a/lact-schema/src/lib.rs b/lact-schema/src/lib.rs
index d2125a0..42d70c4 100644
--- a/lact-schema/src/lib.rs
+++ b/lact-schema/src/lib.rs
@@ -306,3 +306,9 @@ pub struct FanOptions<'a> {
     pub spindown_delay_ms: Option<u64>,
     pub change_threshold: Option<u64>,
 }
+
+#[derive(Serialize, Deserialize, Debug, Clone, PartialEq, Default)]
+pub struct ProfilesInfo {
+    pub profiles: Vec<String>,
+    pub current_profile: Option<String>,
+}
diff --git a/lact-schema/src/request.rs b/lact-schema/src/request.rs
index cf38695..8afc65f 100644
--- a/lact-schema/src/request.rs
+++ b/lact-schema/src/request.rs
@@ -1,3 +1,5 @@
+use std::fmt;
+
 use crate::FanOptions;
 use amdgpu_sysfs::gpu_handle::{PerformanceLevel, PowerLevelKind};
 use serde::{Deserialize, Serialize};
@@ -57,6 +59,17 @@ pub enum Request<'a> {
     VbiosDump {
         id: &'a str,
     },
+    ListProfiles,
+    SetProfile {
+        name: Option<String>,
+    },
+    CreateProfile {
+        name: String,
+        base: ProfileBase,
+    },
+    DeleteProfile {
+        name: String,
+    },
     EnableOverdrive,
     DisableOverdrive,
     GenerateSnapshot,
@@ -83,3 +96,22 @@ pub enum SetClocksCommand {
     VoltageOffset(i32),
     Reset,
 }
+
+#[derive(Serialize, Deserialize, Debug, PartialEq, Clone)]
+#[serde(rename_all = "snake_case")]
+pub enum ProfileBase {
+    Empty,
+    Default,
+    Profile(String),
+}
+
+impl fmt::Display for ProfileBase {
+    fn fmt(&self, f: &mut fmt::Formatter<'_>) -> fmt::Result {
+        let text = match self {
+            ProfileBase::Empty => "Empty",
+            ProfileBase::Default => "Default",
+            ProfileBase::Profile(name) => name,
+        };
+        text.fmt(f)
+    }
+}