diff --git a/package.json b/package.json
index d566b12283c..6e4dfe4ea97 100644
--- a/package.json
+++ b/package.json
@@ -126,7 +126,6 @@
     "@types/react-loadable": "5.5.2",
     "@types/react-redux": "7.1.20",
     "@types/react-router-dom": "^5.1.7",
-    "@types/react-select": "4.0.13",
     "@types/react-test-renderer": "17.0.1",
     "@types/react-transition-group": "4.4.0",
     "@types/react-virtualized-auto-sizer": "1.0.0",
@@ -331,7 +330,7 @@
     "react-resizable": "3.0.4",
     "react-reverse-portal": "^2.0.1",
     "react-router-dom": "^5.2.0",
-    "react-select": "4.3.0",
+    "react-select": "5.2.1",
     "react-split-pane": "0.1.89",
     "react-transition-group": "4.4.1",
     "react-use": "17.2.4",
diff --git a/packages/grafana-ui/package.json b/packages/grafana-ui/package.json
index 2cab487f165..9145da1ccfe 100644
--- a/packages/grafana-ui/package.json
+++ b/packages/grafana-ui/package.json
@@ -76,7 +76,7 @@
     "react-inlinesvg": "2.3.0",
     "react-popper": "2.2.4",
     "react-router-dom": "^5.2.0",
-    "react-select": "4.3.0",
+    "react-select": "5.2.1",
     "react-select-event": "^5.1.0",
     "react-table": "7.7.0",
     "react-transition-group": "4.4.1",
@@ -139,7 +139,6 @@
     "@types/react-color": "3.0.1",
     "@types/react-dom": "17.0.11",
     "@types/react-router-dom": "^5.1.7",
-    "@types/react-select": "4.0.13",
     "@types/react-table": "7.7.2",
     "@types/react-test-renderer": "17.0.1",
     "@types/react-transition-group": "4.4.0",
diff --git a/packages/grafana-ui/src/components/Forms/Legacy/Select/NoOptionsMessage.tsx b/packages/grafana-ui/src/components/Forms/Legacy/Select/NoOptionsMessage.tsx
index 609757a49a6..077199661ed 100644
--- a/packages/grafana-ui/src/components/Forms/Legacy/Select/NoOptionsMessage.tsx
+++ b/packages/grafana-ui/src/components/Forms/Legacy/Select/NoOptionsMessage.tsx
@@ -1,18 +1,17 @@
 import React from 'react';
-import { components, OptionProps } from 'react-select';
+import { components, NoticeProps, GroupBase } from 'react-select';
+import { SelectableValue } from '@grafana/data';
 
-export interface Props {
-  children: Element;
-}
+export type Props<T> = NoticeProps<SelectableValue<T>, boolean, GroupBase<SelectableValue<T>>>;
 
-export const NoOptionsMessage = (props: OptionProps<any, any>) => {
+export const NoOptionsMessage = <T extends unknown>(props: Props<T>) => {
   const { children } = props;
   return (
-    <components.Option {...props}>
+    <components.NoOptionsMessage {...props}>
       <div className="gf-form-select-box__desc-option">
         <div className="gf-form-select-box__desc-option__body">{children}</div>
       </div>
-    </components.Option>
+    </components.NoOptionsMessage>
   );
 };
 
diff --git a/packages/grafana-ui/src/components/Forms/Legacy/Select/Select.tsx b/packages/grafana-ui/src/components/Forms/Legacy/Select/Select.tsx
index 35bc7f3be08..20303334b5c 100644
--- a/packages/grafana-ui/src/components/Forms/Legacy/Select/Select.tsx
+++ b/packages/grafana-ui/src/components/Forms/Legacy/Select/Select.tsx
@@ -216,7 +216,6 @@ export class AsyncSelect<T> extends PureComponent<AsyncProps<T>> {
       <WrapInTooltip onCloseMenu={onCloseMenu} onOpenMenu={onOpenMenu} tooltipContent={tooltipContent} isOpen={isOpen}>
         {(onOpenMenuInternal, onCloseMenuInternal) => {
           return (
-            //@ts-expect-error
             <ReactAsyncSelect
               captureMenuScroll={false}
               classNamePrefix="gf-form-select-box"
@@ -229,14 +228,17 @@ export class AsyncSelect<T> extends PureComponent<AsyncProps<T>> {
               }}
               defaultValue={defaultValue}
               value={value}
+              //@ts-expect-error
               getOptionLabel={getOptionLabel}
               getOptionValue={getOptionValue}
               menuShouldScrollIntoView={false}
+              //@ts-expect-error
               onChange={onChange}
               loadOptions={loadOptions}
               isLoading={isLoading}
               defaultOptions={defaultOptions}
               placeholder={placeholder || 'Choose'}
+              //@ts-expect-error
               styles={resetSelectStyles()}
               loadingMessage={() => loadingMessage}
               noOptionsMessage={noOptionsMessage}
diff --git a/packages/grafana-ui/src/components/Forms/Legacy/Select/SelectOption.test.tsx b/packages/grafana-ui/src/components/Forms/Legacy/Select/SelectOption.test.tsx
index 381743328cd..aa68baed4c6 100644
--- a/packages/grafana-ui/src/components/Forms/Legacy/Select/SelectOption.test.tsx
+++ b/packages/grafana-ui/src/components/Forms/Legacy/Select/SelectOption.test.tsx
@@ -1,9 +1,8 @@
 import React from 'react';
 import renderer from 'react-test-renderer';
 import SelectOption from './SelectOption';
-import { OptionProps } from 'react-select/src/components/Option';
+import { OptionProps } from 'react-select';
 
-// @ts-ignore
 const model: OptionProps<any> = {
   data: jest.fn(),
   cx: jest.fn(),
@@ -14,12 +13,13 @@ const model: OptionProps<any> = {
   isMulti: false,
   options: [],
   selectOption: jest.fn(),
+  // @ts-ignore
   selectProps: {},
   setValue: jest.fn(),
   isDisabled: false,
   isFocused: false,
   isSelected: false,
-  innerRef: null,
+  innerRef: jest.fn(),
   innerProps: {
     id: '',
     key: '',
diff --git a/packages/grafana-ui/src/components/Forms/Legacy/Select/__snapshots__/SelectOption.test.tsx.snap b/packages/grafana-ui/src/components/Forms/Legacy/Select/__snapshots__/SelectOption.test.tsx.snap
index 393d101afd2..c5a0bd370a0 100644
--- a/packages/grafana-ui/src/components/Forms/Legacy/Select/__snapshots__/SelectOption.test.tsx.snap
+++ b/packages/grafana-ui/src/components/Forms/Legacy/Select/__snapshots__/SelectOption.test.tsx.snap
@@ -2,6 +2,7 @@
 
 exports[`SelectOption renders correctly 1`] = `
 <div
+  aria-disabled={false}
   className="css-o8533i-Option"
   id=""
   onClick={[MockFunction]}
diff --git a/packages/grafana-ui/src/components/Select/Container.tsx b/packages/grafana-ui/src/components/Select/Container.tsx
index d6636fab96e..97095b3d401 100644
--- a/packages/grafana-ui/src/components/Select/Container.tsx
+++ b/packages/grafana-ui/src/components/Select/Container.tsx
@@ -6,20 +6,15 @@ import { css, cx } from '@emotion/css';
 import { stylesFactory } from '../../themes';
 import { GrafanaTheme2 } from '@grafana/data';
 import { focusCss } from '../../themes/mixins';
-import { components, ContainerProps, GroupTypeBase } from 'react-select';
+import { components, ContainerProps, GroupBase } from 'react-select';
 
-export const SelectContainer = <Option, isMulti extends boolean, Group extends GroupTypeBase<Option>>(
+export const SelectContainer = <Option, isMulti extends boolean, Group extends GroupBase<Option>>(
   props: ContainerProps<Option, isMulti, Group> & { isFocused: boolean }
 ) => {
-  const {
-    isDisabled,
-    isFocused,
-    children,
-    selectProps: { prefix },
-  } = props;
+  const { isDisabled, isFocused, children } = props;
 
   const theme = useTheme2();
-  const styles = getSelectContainerStyles(theme, isFocused, isDisabled, !!prefix);
+  const styles = getSelectContainerStyles(theme, isFocused, isDisabled);
 
   return (
     <components.SelectContainer {...props} className={cx(styles.wrapper, props.className)}>
@@ -28,41 +23,35 @@ export const SelectContainer = <Option, isMulti extends boolean, Group extends G
   );
 };
 
-const getSelectContainerStyles = stylesFactory(
-  (theme: GrafanaTheme2, focused: boolean, disabled: boolean, withPrefix: boolean) => {
-    const styles = getInputStyles({ theme, invalid: false });
+const getSelectContainerStyles = stylesFactory((theme: GrafanaTheme2, focused: boolean, disabled: boolean) => {
+  const styles = getInputStyles({ theme, invalid: false });
 
-    return {
-      wrapper: cx(
-        styles.wrapper,
-        sharedInputStyle(theme, false),
-        focused &&
-          css`
-            ${focusCss(theme.v1)}
-          `,
-        disabled && styles.inputDisabled,
+  return {
+    wrapper: cx(
+      styles.wrapper,
+      sharedInputStyle(theme, false),
+      focused &&
         css`
-          position: relative;
-          box-sizing: border-box;
-          display: flex;
-          flex-direction: row;
-          flex-wrap: wrap;
-          align-items: center;
-          justify-content: space-between;
-
-          min-height: 32px;
-          height: auto;
-          max-width: 100%;
-
-          /* Input padding is applied to the InputControl so the menu is aligned correctly */
-          padding: 0;
-          cursor: ${disabled ? 'not-allowed' : 'pointer'};
+          ${focusCss(theme.v1)}
         `,
-        withPrefix &&
-          css`
-            padding-left: 0;
-          `
-      ),
-    };
-  }
-);
+      disabled && styles.inputDisabled,
+      css`
+        position: relative;
+        box-sizing: border-box;
+        display: flex;
+        flex-direction: row;
+        flex-wrap: wrap;
+        align-items: center;
+        justify-content: space-between;
+
+        min-height: 32px;
+        height: auto;
+        max-width: 100%;
+
+        /* Input padding is applied to the InputControl so the menu is aligned correctly */
+        padding: 0;
+        cursor: ${disabled ? 'not-allowed' : 'pointer'};
+      `
+    ),
+  };
+});
diff --git a/packages/grafana-ui/src/components/Select/SelectBase.test.tsx b/packages/grafana-ui/src/components/Select/SelectBase.test.tsx
index 9530fa31657..81033a3de78 100644
--- a/packages/grafana-ui/src/components/Select/SelectBase.test.tsx
+++ b/packages/grafana-ui/src/components/Select/SelectBase.test.tsx
@@ -62,7 +62,7 @@ describe('SelectBase', () => {
     describe('is provided', () => {
       it('opens on focus', () => {
         render(<SelectBase menuShouldPortal onChange={onChangeHandler} openMenuOnFocus />);
-        fireEvent.focus(screen.getByRole('textbox'));
+        fireEvent.focus(screen.getByRole('combobox'));
         expect(screen.queryByText(/no options found/i)).toBeVisible();
       });
     });
@@ -74,8 +74,8 @@ describe('SelectBase', () => {
         ${' '}
       `('opens on arrow down/up or space', ({ key }) => {
         render(<SelectBase menuShouldPortal onChange={onChangeHandler} />);
-        fireEvent.focus(screen.getByRole('textbox'));
-        fireEvent.keyDown(screen.getByRole('textbox'), { key });
+        fireEvent.focus(screen.getByRole('combobox'));
+        fireEvent.keyDown(screen.getByRole('combobox'), { key });
         expect(screen.queryByText(/no options found/i)).toBeVisible();
       });
     });
diff --git a/packages/grafana-ui/src/components/Select/SelectContainer.tsx b/packages/grafana-ui/src/components/Select/SelectContainer.tsx
index f322e6e34f2..0e148b636c2 100644
--- a/packages/grafana-ui/src/components/Select/SelectContainer.tsx
+++ b/packages/grafana-ui/src/components/Select/SelectContainer.tsx
@@ -6,26 +6,21 @@ import { css, cx } from '@emotion/css';
 import { stylesFactory } from '../../themes';
 import { GrafanaTheme2 } from '@grafana/data';
 import { focusCss } from '../../themes/mixins';
-import { components, ContainerProps as BaseContainerProps, GroupTypeBase } from 'react-select';
+import { components, ContainerProps as BaseContainerProps, GroupBase } from 'react-select';
 
 // isFocus prop is actually available, but its not in the types for the version we have.
-export interface ContainerProps<Option, isMulti extends boolean, Group extends GroupTypeBase<Option>>
+export interface ContainerProps<Option, isMulti extends boolean, Group extends GroupBase<Option>>
   extends BaseContainerProps<Option, isMulti, Group> {
   isFocused: boolean;
 }
 
-export const SelectContainer = <Option, isMulti extends boolean, Group extends GroupTypeBase<Option>>(
+export const SelectContainer = <Option, isMulti extends boolean, Group extends GroupBase<Option>>(
   props: ContainerProps<Option, isMulti, Group>
 ) => {
-  const {
-    isDisabled,
-    isFocused,
-    children,
-    selectProps: { prefix },
-  } = props;
+  const { isDisabled, isFocused, children } = props;
 
   const theme = useTheme2();
-  const styles = getSelectContainerStyles(theme, isFocused, isDisabled, !!prefix);
+  const styles = getSelectContainerStyles(theme, isFocused, isDisabled);
 
   return (
     <components.SelectContainer {...props} className={cx(styles.wrapper, props.className)}>
@@ -34,41 +29,35 @@ export const SelectContainer = <Option, isMulti extends boolean, Group extends G
   );
 };
 
-const getSelectContainerStyles = stylesFactory(
-  (theme: GrafanaTheme2, focused: boolean, disabled: boolean, withPrefix: boolean) => {
-    const styles = getInputStyles({ theme, invalid: false });
+const getSelectContainerStyles = stylesFactory((theme: GrafanaTheme2, focused: boolean, disabled: boolean) => {
+  const styles = getInputStyles({ theme, invalid: false });
 
-    return {
-      wrapper: cx(
-        styles.wrapper,
-        sharedInputStyle(theme, false),
-        focused &&
-          css`
-            ${focusCss(theme.v1)}
-          `,
-        disabled && styles.inputDisabled,
+  return {
+    wrapper: cx(
+      styles.wrapper,
+      sharedInputStyle(theme, false),
+      focused &&
         css`
-          position: relative;
-          box-sizing: border-box;
-          /* The display property is set by the styles prop in SelectBase because it's dependant on the width prop  */
-          flex-direction: row;
-          flex-wrap: wrap;
-          align-items: center;
-          justify-content: space-between;
-
-          min-height: 32px;
-          height: auto;
-          max-width: 100%;
-
-          /* Input padding is applied to the InputControl so the menu is aligned correctly */
-          padding: 0;
-          cursor: ${disabled ? 'not-allowed' : 'pointer'};
+          ${focusCss(theme.v1)}
         `,
-        withPrefix &&
-          css`
-            padding-left: 0;
-          `
-      ),
-    };
-  }
-);
+      disabled && styles.inputDisabled,
+      css`
+        position: relative;
+        box-sizing: border-box;
+        /* The display property is set by the styles prop in SelectBase because it's dependant on the width prop  */
+        flex-direction: row;
+        flex-wrap: wrap;
+        align-items: center;
+        justify-content: space-between;
+
+        min-height: 32px;
+        height: auto;
+        max-width: 100%;
+
+        /* Input padding is applied to the InputControl so the menu is aligned correctly */
+        padding: 0;
+        cursor: ${disabled ? 'not-allowed' : 'pointer'};
+      `
+    ),
+  };
+});
diff --git a/packages/grafana-ui/src/components/Select/SingleValue.tsx b/packages/grafana-ui/src/components/Select/SingleValue.tsx
index 281153b33c0..64a03ca9096 100644
--- a/packages/grafana-ui/src/components/Select/SingleValue.tsx
+++ b/packages/grafana-ui/src/components/Select/SingleValue.tsx
@@ -1,12 +1,12 @@
 import React from 'react';
 import { css, cx } from '@emotion/css';
-import { components, SingleValueProps } from 'react-select';
+import { components, GroupBase, SingleValueProps } from 'react-select';
 import { useDelayedSwitch } from '../../utils/useDelayedSwitch';
 import { useStyles2 } from '../../themes';
 import { SlideOutTransition } from '../transitions/SlideOutTransition';
 import { FadeTransition } from '../transitions/FadeTransition';
 import { Spinner } from '../Spinner/Spinner';
-import { GrafanaTheme2 } from '@grafana/data';
+import { GrafanaTheme2, SelectableValue } from '@grafana/data';
 import tinycolor from 'tinycolor2';
 
 const getStyles = (theme: GrafanaTheme2) => {
@@ -44,27 +44,23 @@ const getStyles = (theme: GrafanaTheme2) => {
 
 type StylesType = ReturnType<typeof getStyles>;
 
-interface Props
-  extends SingleValueProps<{
-    imgUrl?: string;
-    label?: string;
-    value: string;
-    loading?: boolean;
-    hideText?: boolean;
-  }> {
-  disabled?: boolean;
-}
+export type Props<T> = SingleValueProps<SelectableValue<T>, boolean, GroupBase<SelectableValue<T>>>;
 
-export const SingleValue = (props: Props) => {
-  const { children, data, disabled } = props;
+export const SingleValue = <T extends unknown>(props: Props<T>) => {
+  const { children, data, isDisabled } = props;
   const styles = useStyles2(getStyles);
   const loading = useDelayedSwitch(data.loading || false, { delay: 250, duration: 750 });
 
   return (
     <components.SingleValue {...props}>
-      <div className={cx(styles.singleValue, disabled && styles.disabled)}>
+      <div className={cx(styles.singleValue, isDisabled && styles.disabled)}>
         {data.imgUrl ? (
-          <FadeWithImage loading={loading} imgUrl={data.imgUrl} styles={styles} alt={data.label || data.value} />
+          <FadeWithImage
+            loading={loading}
+            imgUrl={data.imgUrl}
+            styles={styles}
+            alt={(data.label || data.value) as string}
+          />
         ) : (
           <SlideOutTransition horizontal size={16} visible={loading} duration={150}>
             <div className={styles.container}>
@@ -78,7 +74,7 @@ export const SingleValue = (props: Props) => {
   );
 };
 
-const FadeWithImage = (props: { loading: boolean; imgUrl: string; styles: StylesType; alt: string }) => {
+const FadeWithImage = (props: { loading: boolean; imgUrl: string; styles: StylesType; alt?: string }) => {
   return (
     <div className={props.styles.container}>
       <FadeTransition duration={150} visible={props.loading}>
diff --git a/packages/grafana-ui/src/components/Select/types.ts b/packages/grafana-ui/src/components/Select/types.ts
index e9ca7b9a5f1..c7493a69866 100644
--- a/packages/grafana-ui/src/components/Select/types.ts
+++ b/packages/grafana-ui/src/components/Select/types.ts
@@ -1,6 +1,6 @@
 import { SelectableValue } from '@grafana/data';
 import React from 'react';
-import { ActionMeta as SelectActionMeta } from 'react-select';
+import { ActionMeta as SelectActionMeta, GroupBase, OptionsOrGroups } from 'react-select';
 
 export type SelectValue<T> = T | SelectableValue<T> | T[] | Array<SelectableValue<T>>;
 export type ActionMeta = SelectActionMeta<{}>;
@@ -77,7 +77,7 @@ export interface SelectCommonProps<T> {
   isValidNewOption?: (
     inputValue: string,
     value: SelectableValue<T> | null,
-    options: Readonly<Array<SelectableValue<T>>>
+    options: OptionsOrGroups<unknown, GroupBase<unknown>>
   ) => boolean;
 }
 
diff --git a/public/app/core/components/Select/ReadonlyFolderPicker/ReadonlyFolderPicker.test.tsx b/public/app/core/components/Select/ReadonlyFolderPicker/ReadonlyFolderPicker.test.tsx
index c5b16e48bf1..d92d74df741 100644
--- a/public/app/core/components/Select/ReadonlyFolderPicker/ReadonlyFolderPicker.test.tsx
+++ b/public/app/core/components/Select/ReadonlyFolderPicker/ReadonlyFolderPicker.test.tsx
@@ -74,9 +74,9 @@ describe('ReadonlyFolderPicker', () => {
     it('then query is passed correctly to getFoldersAsOptions', async () => {
       const { getFoldersAsOptionsSpy, selectors } = await getTestContext();
 
-      expect(within(selectors.container.get()).getByRole('textbox')).toBeInTheDocument();
+      expect(within(selectors.container.get()).getByRole('combobox')).toBeInTheDocument();
       getFoldersAsOptionsSpy.mockClear();
-      userEvent.type(within(selectors.container.get()).getByRole('textbox'), 'A');
+      userEvent.type(within(selectors.container.get()).getByRole('combobox'), 'A');
       await waitFor(() => expect(getFoldersAsOptionsSpy).toHaveBeenCalledTimes(1));
 
       expect(getFoldersAsOptionsSpy).toHaveBeenCalledWith({
diff --git a/public/app/core/components/TagFilter/TagOption.tsx b/public/app/core/components/TagFilter/TagOption.tsx
index 8448d01e279..3505e958764 100644
--- a/public/app/core/components/TagFilter/TagOption.tsx
+++ b/public/app/core/components/TagFilter/TagOption.tsx
@@ -3,7 +3,7 @@ import { css, cx } from '@emotion/css';
 import { useTheme, stylesFactory } from '@grafana/ui';
 import { GrafanaTheme } from '@grafana/data';
 
-import { OptionProps } from 'react-select/src/components/Option';
+import { OptionProps } from 'react-select';
 import { TagBadge } from './TagBadge';
 
 // https://github.com/JedWatson/react-select/issues/3038
diff --git a/public/app/features/alerting/unified/AlertGroups.test.tsx b/public/app/features/alerting/unified/AlertGroups.test.tsx
index cd307e540d6..2d6d4e90e40 100644
--- a/public/app/features/alerting/unified/AlertGroups.test.tsx
+++ b/public/app/features/alerting/unified/AlertGroups.test.tsx
@@ -49,7 +49,7 @@ const ui = {
   sourceButton: byText('See source'),
   matcherInput: byTestId('search-query-input'),
   groupByContainer: byTestId('group-by-container'),
-  groupByInput: byRole('textbox', { name: /group by label keys/i }),
+  groupByInput: byRole('combobox', { name: /group by label keys/i }),
   clearButton: byRole('button', { name: 'Clear filters' }),
 };
 
diff --git a/public/app/features/alerting/unified/AmRoutes.test.tsx b/public/app/features/alerting/unified/AmRoutes.test.tsx
index a55faa6076b..12cdb66ccb4 100644
--- a/public/app/features/alerting/unified/AmRoutes.test.tsx
+++ b/public/app/features/alerting/unified/AmRoutes.test.tsx
@@ -258,7 +258,7 @@ describe('AmRoutes', () => {
     await clickSelectOption(receiverSelect, 'critical');
 
     const groupSelect = ui.groupSelect.get();
-    userEvent.type(byRole('textbox').get(groupSelect), 'namespace{enter}');
+    userEvent.type(byRole('combobox').get(groupSelect), 'namespace{enter}');
 
     // configure timing intervals
     userEvent.click(byText('Timing options').get(rootRouteContainer));
@@ -317,8 +317,8 @@ describe('AmRoutes', () => {
     await clickSelectOption(receiverSelect, 'default');
 
     const groupSelect = ui.groupSelect.get();
-    userEvent.type(byRole('textbox').get(groupSelect), 'severity{enter}');
-    userEvent.type(byRole('textbox').get(groupSelect), 'namespace{enter}');
+    userEvent.type(byRole('combobox').get(groupSelect), 'severity{enter}');
+    userEvent.type(byRole('combobox').get(groupSelect), 'namespace{enter}');
     //save
     userEvent.click(ui.saveButton.get(rootRouteContainer));
 
@@ -531,14 +531,14 @@ describe('AmRoutes', () => {
 });
 
 const clickSelectOption = async (selectElement: HTMLElement, optionText: string): Promise<void> => {
-  userEvent.click(byRole('textbox').get(selectElement));
+  userEvent.click(byRole('combobox').get(selectElement));
   await selectOptionInTest(selectElement, optionText);
 };
 
 const updateTiming = async (selectElement: HTMLElement, value: string, timeUnit: string): Promise<void> => {
-  const inputs = byRole('textbox').queryAll(selectElement);
-  expect(inputs).toHaveLength(2);
-  userEvent.type(inputs[0], value);
-  userEvent.click(inputs[1]);
+  const input = byRole('textbox').get(selectElement);
+  const select = byRole('combobox').get(selectElement);
+  userEvent.type(input, value);
+  userEvent.click(select);
   await selectOptionInTest(selectElement, timeUnit);
 };
diff --git a/public/app/features/alerting/unified/Receivers.test.tsx b/public/app/features/alerting/unified/Receivers.test.tsx
index 69c09a573ee..e75408c7c80 100644
--- a/public/app/features/alerting/unified/Receivers.test.tsx
+++ b/public/app/features/alerting/unified/Receivers.test.tsx
@@ -113,7 +113,7 @@ const ui = {
 };
 
 const clickSelectOption = async (selectElement: HTMLElement, optionText: string): Promise<void> => {
-  userEvent.click(byRole('textbox').get(selectElement));
+  userEvent.click(byRole('combobox').get(selectElement));
   await selectOptionInTest(selectElement, optionText);
 };
 
diff --git a/public/app/features/alerting/unified/RuleEditor.test.tsx b/public/app/features/alerting/unified/RuleEditor.test.tsx
index df4d7633044..b4bcd63e88e 100644
--- a/public/app/features/alerting/unified/RuleEditor.test.tsx
+++ b/public/app/features/alerting/unified/RuleEditor.test.tsx
@@ -129,7 +129,7 @@ describe('RuleEditor', () => {
     userEvent.type(await ui.inputs.name.find(), 'my great new rule');
     await clickSelectOption(ui.inputs.alertType.get(), /Cortex\/Loki managed alert/);
     const dataSourceSelect = ui.inputs.dataSource.get();
-    userEvent.click(byRole('textbox').get(dataSourceSelect));
+    userEvent.click(byRole('combobox').get(dataSourceSelect));
     await clickSelectOption(dataSourceSelect, 'Prom (default)');
     await waitFor(() => expect(mocks.api.fetchRulerRules).toHaveBeenCalled());
     await clickSelectOption(ui.inputs.namespace.get(), 'namespace2');
@@ -270,7 +270,7 @@ describe('RuleEditor', () => {
     userEvent.type(await ui.inputs.name.find(), 'my great new recording rule');
     await clickSelectOption(ui.inputs.alertType.get(), /Cortex\/Loki managed recording rule/);
     const dataSourceSelect = ui.inputs.dataSource.get();
-    userEvent.click(byRole('textbox').get(dataSourceSelect));
+    userEvent.click(byRole('combobox').get(dataSourceSelect));
     await clickSelectOption(dataSourceSelect, 'Prom (default)');
     await waitFor(() => expect(mocks.api.fetchRulerRules).toHaveBeenCalled());
     await clickSelectOption(ui.inputs.namespace.get(), 'namespace2');
@@ -496,7 +496,7 @@ describe('RuleEditor', () => {
 
     // check that only rules sources that have ruler available are there
     const dataSourceSelect = ui.inputs.dataSource.get();
-    userEvent.click(byRole('textbox').get(dataSourceSelect));
+    userEvent.click(byRole('combobox').get(dataSourceSelect));
     expect(await byText('loki with ruler').query()).toBeInTheDocument();
     expect(byText('cortex with ruler').query()).toBeInTheDocument();
     expect(byText('loki with local rule store').query()).not.toBeInTheDocument();
@@ -507,6 +507,6 @@ describe('RuleEditor', () => {
 });
 
 const clickSelectOption = async (selectElement: HTMLElement, optionText: Matcher): Promise<void> => {
-  userEvent.click(byRole('textbox').get(selectElement));
+  userEvent.click(byRole('combobox').get(selectElement));
   await selectOptionInTest(selectElement, optionText as string);
 };
diff --git a/public/app/features/dashboard/components/DashboardSettings/GeneralSettings.test.tsx b/public/app/features/dashboard/components/DashboardSettings/GeneralSettings.test.tsx
index 037f5c7a3b0..6b6f80a729c 100644
--- a/public/app/features/dashboard/components/DashboardSettings/GeneralSettings.test.tsx
+++ b/public/app/features/dashboard/components/DashboardSettings/GeneralSettings.test.tsx
@@ -50,7 +50,7 @@ describe('General Settings', () => {
       const { props } = setupTestContext({});
       userEvent.click(screen.getByTestId(selectors.components.TimeZonePicker.containerV2));
       const timeZonePicker = screen.getByTestId(selectors.components.TimeZonePicker.containerV2);
-      userEvent.click(byRole('textbox').get(timeZonePicker));
+      userEvent.click(byRole('combobox').get(timeZonePicker));
       await selectOptionInTest(timeZonePicker, 'Browser Time');
       expect(props.updateTimeZone).toHaveBeenCalledWith('browser');
       expect(props.dashboard.timezone).toBe('browser');
diff --git a/public/app/features/inspector/InspectDataTab.test.tsx b/public/app/features/inspector/InspectDataTab.test.tsx
index b751871c3ff..8ee0e98e2b6 100644
--- a/public/app/features/inspector/InspectDataTab.test.tsx
+++ b/public/app/features/inspector/InspectDataTab.test.tsx
@@ -57,7 +57,7 @@ describe('InspectDataTab', () => {
       render(<InspectDataTab {...createProps()} />);
       const dataOptions = screen.getByText(/Data options/i);
       userEvent.click(dataOptions);
-      const dataFrameInput = screen.getByRole('textbox', { name: /Select dataframe/i });
+      const dataFrameInput = screen.getByRole('combobox', { name: /Select dataframe/i });
       userEvent.click(dataFrameInput);
       expect(screen.getByText(/Second data frame/i)).toBeInTheDocument();
     });
diff --git a/public/app/features/library-panels/components/LibraryPanelsSearch/LibraryPanelsSearch.test.tsx b/public/app/features/library-panels/components/LibraryPanelsSearch/LibraryPanelsSearch.test.tsx
index 5a278cf051f..8ebc33dc10c 100644
--- a/public/app/features/library-panels/components/LibraryPanelsSearch/LibraryPanelsSearch.test.tsx
+++ b/public/app/features/library-panels/components/LibraryPanelsSearch/LibraryPanelsSearch.test.tsx
@@ -141,7 +141,7 @@ describe('LibraryPanelsSearch', () => {
 
       expect(screen.getByPlaceholderText(/search by name/i)).toBeInTheDocument();
       expect(screen.getByText(/no library panels found./i)).toBeInTheDocument();
-      expect(screen.getByRole('textbox', { name: /panel type filter/i })).toBeInTheDocument();
+      expect(screen.getByRole('combobox', { name: /panel type filter/i })).toBeInTheDocument();
     });
 
     describe('and user changes panel filter', () => {
@@ -149,8 +149,8 @@ describe('LibraryPanelsSearch', () => {
         const { getLibraryPanelsSpy } = await getTestContext({ showPanelFilter: true });
         getLibraryPanelsSpy.mockClear();
 
-        userEvent.type(screen.getByRole('textbox', { name: /panel type filter/i }), 'Graph{enter}');
-        userEvent.type(screen.getByRole('textbox', { name: /panel type filter/i }), 'Time Series{enter}');
+        userEvent.type(screen.getByRole('combobox', { name: /panel type filter/i }), 'Graph{enter}');
+        userEvent.type(screen.getByRole('combobox', { name: /panel type filter/i }), 'Time Series{enter}');
         await waitFor(() => expect(getLibraryPanelsSpy).toHaveBeenCalledTimes(1));
         expect(getLibraryPanelsSpy).toHaveBeenCalledWith({
           searchString: '',
@@ -169,7 +169,7 @@ describe('LibraryPanelsSearch', () => {
 
       expect(screen.getByPlaceholderText(/search by name/i)).toBeInTheDocument();
       expect(screen.getByText(/no library panels found./i)).toBeInTheDocument();
-      expect(screen.getByRole('textbox', { name: /folder filter/i })).toBeInTheDocument();
+      expect(screen.getByRole('combobox', { name: /folder filter/i })).toBeInTheDocument();
     });
 
     describe('and user changes folder filter', () => {
@@ -177,8 +177,8 @@ describe('LibraryPanelsSearch', () => {
         const { getLibraryPanelsSpy } = await getTestContext({ showFolderFilter: true });
         getLibraryPanelsSpy.mockClear();
 
-        userEvent.click(screen.getByRole('textbox', { name: /folder filter/i }));
-        userEvent.type(screen.getByRole('textbox', { name: /folder filter/i }), '{enter}', {
+        userEvent.click(screen.getByRole('combobox', { name: /folder filter/i }));
+        userEvent.type(screen.getByRole('combobox', { name: /folder filter/i }), '{enter}', {
           skipClick: true,
         });
         await waitFor(() => expect(getLibraryPanelsSpy).toHaveBeenCalledTimes(1));
diff --git a/public/app/features/variables/adhoc/actions.ts b/public/app/features/variables/adhoc/actions.ts
index 2781dfb0e11..a24152e2831 100644
--- a/public/app/features/variables/adhoc/actions.ts
+++ b/public/app/features/variables/adhoc/actions.ts
@@ -30,7 +30,6 @@ const filterTableName = 'Filters';
 export const applyFilterFromTable = (options: AdHocTableOptions): ThunkResult<void> => {
   return async (dispatch, getState) => {
     let variable = getVariableByOptions(options, getState());
-    console.log('getVariableByOptions', options, getState().templating.variables);
 
     if (!variable) {
       dispatch(createAdHocVariable(options));
diff --git a/public/app/plugins/datasource/cloudwatch/components/ui/InlineSelect.tsx b/public/app/plugins/datasource/cloudwatch/components/ui/InlineSelect.tsx
index efa201cbd02..465b2149d6a 100644
--- a/public/app/plugins/datasource/cloudwatch/components/ui/InlineSelect.tsx
+++ b/public/app/plugins/datasource/cloudwatch/components/ui/InlineSelect.tsx
@@ -7,7 +7,7 @@ import {
 } from '@grafana/ui/src/components/Select/SelectContainer';
 import { SelectCommonProps } from '@grafana/ui/src/components/Select/types';
 import React, { useState } from 'react';
-import { GroupTypeBase } from 'react-select';
+import { GroupBase } from 'react-select';
 
 interface InlineSelectProps<T> extends SelectCommonProps<T> {
   label?: string;
@@ -38,7 +38,7 @@ function InlineSelect<T>({ label: labelProp, ...props }: InlineSelectProps<T>) {
 
 export default InlineSelect;
 
-const SelectContainer = <Option, isMulti extends boolean, Group extends GroupTypeBase<Option>>(
+const SelectContainer = <Option, isMulti extends boolean, Group extends GroupBase<Option>>(
   props: ContainerProps<Option, isMulti, Group>
 ) => {
   const { children } = props;
@@ -53,7 +53,7 @@ const SelectContainer = <Option, isMulti extends boolean, Group extends GroupTyp
   );
 };
 
-const ValueContainer = <Option, isMulti extends boolean, Group extends GroupTypeBase<Option>>(
+const ValueContainer = <Option, isMulti extends boolean, Group extends GroupBase<Option>>(
   props: ContainerProps<Option, isMulti, Group>
 ) => {
   const { className, children } = props;
diff --git a/public/app/plugins/datasource/elasticsearch/components/QueryEditor/BucketAggregationsEditor/SettingsEditor/DateHistogramSettingsEditor.tsx b/public/app/plugins/datasource/elasticsearch/components/QueryEditor/BucketAggregationsEditor/SettingsEditor/DateHistogramSettingsEditor.tsx
index 1eef6876005..ef49e941c9f 100644
--- a/public/app/plugins/datasource/elasticsearch/components/QueryEditor/BucketAggregationsEditor/SettingsEditor/DateHistogramSettingsEditor.tsx
+++ b/public/app/plugins/datasource/elasticsearch/components/QueryEditor/BucketAggregationsEditor/SettingsEditor/DateHistogramSettingsEditor.tsx
@@ -1,4 +1,5 @@
 import React from 'react';
+import { GroupBase, OptionsOrGroups } from 'react-select';
 import { InlineField, Input, Select, TimeZonePicker } from '@grafana/ui';
 import { DateHistogram } from '../aggregations';
 import { bucketAggregationConfig } from '../utils';
@@ -25,11 +26,11 @@ const hasValue = (searchValue: string) => ({ value }: SelectableValue<string>) =
 const isValidNewOption = (
   inputValue: string,
   _: SelectableValue<string> | null,
-  options: Readonly<Array<SelectableValue<string>>>
+  options: OptionsOrGroups<unknown, GroupBase<unknown>>
 ) => {
   // TODO: would be extremely nice here to allow only template variables and values that are
   // valid date histogram's Interval options
-  const valueExists = options.some(hasValue(inputValue));
+  const valueExists = (options as Array<SelectableValue<string>>).some(hasValue(inputValue));
   // we also don't want users to create "empty" values
   return !valueExists && inputValue.trim().length > 0;
 };
diff --git a/yarn.lock b/yarn.lock
index 109d48a313d..5fdbfcbf35e 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -1995,7 +1995,7 @@ __metadata:
   languageName: node
   linkType: hard
 
-"@emotion/cache@npm:^11.0.0, @emotion/cache@npm:^11.1.3, @emotion/cache@npm:^11.5.0":
+"@emotion/cache@npm:^11.1.3, @emotion/cache@npm:^11.4.0, @emotion/cache@npm:^11.5.0":
   version: 11.5.0
   resolution: "@emotion/cache@npm:11.5.0"
   dependencies:
@@ -2761,7 +2761,6 @@ __metadata:
     "@types/react-color": 3.0.1
     "@types/react-dom": 17.0.11
     "@types/react-router-dom": ^5.1.7
-    "@types/react-select": 4.0.13
     "@types/react-table": 7.7.2
     "@types/react-test-renderer": 17.0.1
     "@types/react-transition-group": 4.4.0
@@ -2821,7 +2820,7 @@ __metadata:
     react-inlinesvg: 2.3.0
     react-popper: 2.2.4
     react-router-dom: ^5.2.0
-    react-select: 4.3.0
+    react-select: 5.2.1
     react-select-event: ^5.1.0
     react-table: 7.7.0
     react-test-renderer: 17.0.1
@@ -8378,18 +8377,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"@types/react-select@npm:4.0.13":
-  version: 4.0.13
-  resolution: "@types/react-select@npm:4.0.13"
-  dependencies:
-    "@emotion/serialize": ^1.0.0
-    "@types/react": "*"
-    "@types/react-dom": "*"
-    "@types/react-transition-group": "*"
-  checksum: 1a3fdd93a33e8b3fd59ba32c4e952cf057e0f745a3506ac556172ceba4c849e33494dfba1553783f6f55d864a530869f33feefc55306b212146758d612117dba
-  languageName: node
-  linkType: hard
-
 "@types/react-syntax-highlighter@npm:11.0.5":
   version: 11.0.5
   resolution: "@types/react-syntax-highlighter@npm:11.0.5"
@@ -8417,15 +8404,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"@types/react-transition-group@npm:*":
-  version: 4.4.4
-  resolution: "@types/react-transition-group@npm:4.4.4"
-  dependencies:
-    "@types/react": "*"
-  checksum: 86e9ff9731798e12bc2afe0304678918769633b531dcf6397f86af81718fb7930ef8648e894eeb3718fc6eab6eb885cfb9b82a44d1d74e10951ee11ebc4643ae
-  languageName: node
-  linkType: hard
-
 "@types/react-transition-group@npm:4.4.0":
   version: 4.4.0
   resolution: "@types/react-transition-group@npm:4.4.0"
@@ -8435,6 +8413,15 @@ __metadata:
   languageName: node
   linkType: hard
 
+"@types/react-transition-group@npm:^4.4.0":
+  version: 4.4.4
+  resolution: "@types/react-transition-group@npm:4.4.4"
+  dependencies:
+    "@types/react": "*"
+  checksum: 86e9ff9731798e12bc2afe0304678918769633b531dcf6397f86af81718fb7930ef8648e894eeb3718fc6eab6eb885cfb9b82a44d1d74e10951ee11ebc4643ae
+  languageName: node
+  linkType: hard
+
 "@types/react-virtualized-auto-sizer@npm:1.0.0":
   version: 1.0.0
   resolution: "@types/react-virtualized-auto-sizer@npm:1.0.0"
@@ -17980,7 +17967,6 @@ __metadata:
     "@types/react-loadable": 5.5.2
     "@types/react-redux": 7.1.20
     "@types/react-router-dom": ^5.1.7
-    "@types/react-select": 4.0.13
     "@types/react-test-renderer": 17.0.1
     "@types/react-transition-group": 4.4.0
     "@types/react-virtualized-auto-sizer": 1.0.0
@@ -18135,7 +18121,7 @@ __metadata:
     react-resizable: 3.0.4
     react-reverse-portal: ^2.0.1
     react-router-dom: ^5.2.0
-    react-select: 4.3.0
+    react-select: 5.2.1
     react-select-event: ^5.1.0
     react-split-pane: 0.1.89
     react-test-renderer: 17.0.1
@@ -27678,21 +27664,21 @@ __metadata:
   languageName: node
   linkType: hard
 
-"react-select@npm:4.3.0":
-  version: 4.3.0
-  resolution: "react-select@npm:4.3.0"
+"react-select@npm:5.2.1":
+  version: 5.2.1
+  resolution: "react-select@npm:5.2.1"
   dependencies:
     "@babel/runtime": ^7.12.0
-    "@emotion/cache": ^11.0.0
+    "@emotion/cache": ^11.4.0
     "@emotion/react": ^11.1.1
+    "@types/react-transition-group": ^4.4.0
     memoize-one: ^5.0.0
     prop-types: ^15.6.0
-    react-input-autosize: ^3.0.0
     react-transition-group: ^4.3.0
   peerDependencies:
     react: ^16.8.0 || ^17.0.0
     react-dom: ^16.8.0 || ^17.0.0
-  checksum: 00946ed4dfa46523bc44cd26aab11431396632097207081b471d1965fa53cf7f5a006ac11d89b8a65df05cc5376b1c4438edb1d5259323bdc6d3adf01c79d53e
+  checksum: 014cde5d23ca466795bd7f02455769efda74522c41f11109ec2d6f0e3c77f401ea91ae23cdccce997efb653aa6ea88688a16f40e59bfdef2a2414d0cfd10f374
   languageName: node
   linkType: hard