diff --git a/package.json b/package.json
index 1d9aab08d64..251cba9270b 100644
--- a/package.json
+++ b/package.json
@@ -213,8 +213,8 @@
     "testing-library-selector": "^0.1.3",
     "ts-jest": "26.4.4",
     "ts-node": "9.0.0",
-    "tslib": "2.2.0",
-    "typescript": "4.3.4",
+    "tslib": "2.3.1",
+    "typescript": "4.4.3",
     "wait-on": "6.0.0",
     "webpack": "5.51.1",
     "webpack-bundle-analyzer": "4.4.2",
diff --git a/packages/grafana-data/package.json b/packages/grafana-data/package.json
index d521b864cfc..ecd4a35abbf 100644
--- a/packages/grafana-data/package.json
+++ b/packages/grafana-data/package.json
@@ -55,7 +55,7 @@
     "rollup-plugin-visualizer": "4.2.0",
     "sinon": "8.1.1",
     "tinycolor2": "1.4.1",
-    "typescript": "4.3.4"
+    "typescript": "4.4.3"
   },
   "volta": {
     "extends": "../../package.json"
diff --git a/packages/grafana-e2e-selectors/package.json b/packages/grafana-e2e-selectors/package.json
index 61f4a7da976..794ac85bcc8 100644
--- a/packages/grafana-e2e-selectors/package.json
+++ b/packages/grafana-e2e-selectors/package.json
@@ -43,7 +43,7 @@
     "@grafana/tsconfig": "^1.0.0-rc1",
     "commander": "5.0.0",
     "execa": "4.0.0",
-    "typescript": "4.3.4",
+    "typescript": "4.4.3",
     "yaml": "^1.8.3"
   },
   "volta": {
diff --git a/packages/grafana-e2e/package.json b/packages/grafana-e2e/package.json
index 6f998078da9..b0a7d29f9be 100644
--- a/packages/grafana-e2e/package.json
+++ b/packages/grafana-e2e/package.json
@@ -55,7 +55,7 @@
     "execa": "4.0.0",
     "resolve-as-bin": "2.1.0",
     "ts-loader": "6.2.1",
-    "typescript": "4.3.4",
+    "typescript": "4.4.3",
     "yaml": "^1.8.3"
   },
   "volta": {
diff --git a/packages/grafana-runtime/package.json b/packages/grafana-runtime/package.json
index 6da7961e047..157bfade0c3 100644
--- a/packages/grafana-runtime/package.json
+++ b/packages/grafana-runtime/package.json
@@ -44,7 +44,7 @@
     "rollup-plugin-terser": "7.0.2",
     "rollup-plugin-typescript2": "0.29.0",
     "rollup-plugin-visualizer": "4.2.0",
-    "typescript": "4.3.4"
+    "typescript": "4.4.3"
   },
   "types": "src/index.ts",
   "volta": {
diff --git a/packages/grafana-schema/package.json b/packages/grafana-schema/package.json
index 3fa6c0e4d4c..bb102310f5d 100644
--- a/packages/grafana-schema/package.json
+++ b/packages/grafana-schema/package.json
@@ -33,7 +33,7 @@
     "rollup-plugin-terser": "7.0.2",
     "rollup-plugin-typescript2": "0.29.0",
     "rollup-plugin-visualizer": "4.2.0",
-    "typescript": "4.3.4"
+    "typescript": "4.4.3"
   },
   "volta": {
     "extends": "../../package.json"
diff --git a/packages/grafana-toolkit/package.json b/packages/grafana-toolkit/package.json
index 633f181ef0d..4dcd9b6943c 100644
--- a/packages/grafana-toolkit/package.json
+++ b/packages/grafana-toolkit/package.json
@@ -103,8 +103,8 @@
     "ts-jest": "26.4.4",
     "ts-loader": "6.2.1",
     "ts-node": "9.0.0",
-    "tslib": "2.2.0",
-    "typescript": "4.3.4",
+    "tslib": "2.3.1",
+    "typescript": "4.4.3",
     "url-loader": "^2.0.1",
     "webpack": "4.41.5"
   },
diff --git a/packages/grafana-toolkit/src/cli/tasks/package.build.ts b/packages/grafana-toolkit/src/cli/tasks/package.build.ts
index 0d72e4c2b2a..5e00ffb2f47 100644
--- a/packages/grafana-toolkit/src/cli/tasks/package.build.ts
+++ b/packages/grafana-toolkit/src/cli/tasks/package.build.ts
@@ -1,6 +1,5 @@
 import execa = require('execa');
 import { promises as fs } from 'fs';
-// @ts-ignore
 import * as path from 'path';
 import chalk from 'chalk';
 import { useSpinner } from '../utils/useSpinner';
diff --git a/packages/grafana-toolkit/src/cli/tasks/plugin.ci.ts b/packages/grafana-toolkit/src/cli/tasks/plugin.ci.ts
index 16a4c5d8086..eb880cd5c96 100644
--- a/packages/grafana-toolkit/src/cli/tasks/plugin.ci.ts
+++ b/packages/grafana-toolkit/src/cli/tasks/plugin.ci.ts
@@ -2,8 +2,6 @@ import { Task, TaskRunner } from './task';
 import { pluginBuildRunner } from './plugin.build';
 import { getPluginJson } from '../../config/utils/pluginValidation';
 import { getPluginId } from '../../config/utils/getPluginId';
-
-// @ts-ignore
 import execa = require('execa');
 import path = require('path');
 import fs from 'fs-extra';
diff --git a/packages/grafana-toolkit/src/cli/tasks/plugin.dev.ts b/packages/grafana-toolkit/src/cli/tasks/plugin.dev.ts
index 34eeb0b93fc..7585bdf5956 100644
--- a/packages/grafana-toolkit/src/cli/tasks/plugin.dev.ts
+++ b/packages/grafana-toolkit/src/cli/tasks/plugin.dev.ts
@@ -2,8 +2,6 @@ import { Task, TaskRunner } from './task';
 import { bundlePlugin as bundleFn, PluginBundleOptions } from './plugin/bundle';
 import { useSpinner } from '../utils/useSpinner';
 import { lintPlugin } from './plugin.build';
-
-// @ts-ignore
 import execa = require('execa');
 import path = require('path');
 
@@ -15,7 +13,7 @@ const yarnlink = () =>
     try {
       // Make sure we are not using package.json defined toolkit
       await execa('yarn', ['remove', '@grafana/toolkit']);
-    } catch (e) {
+    } catch (e: any) {
       console.log('\n', e.message, '\n');
     }
     await execa('yarn', ['link', '@grafana/toolkit']);
diff --git a/packages/grafana-toolkit/src/cli/tasks/plugin.utils.ts b/packages/grafana-toolkit/src/cli/tasks/plugin.utils.ts
index 92940148274..2ffeabfc784 100755
--- a/packages/grafana-toolkit/src/cli/tasks/plugin.utils.ts
+++ b/packages/grafana-toolkit/src/cli/tasks/plugin.utils.ts
@@ -5,8 +5,6 @@ import { getPluginId } from '../../config/utils/getPluginId';
 import { getCiFolder } from '../../plugins/env';
 import { useSpinner } from '../utils/useSpinner';
 import path = require('path');
-
-// @ts-ignore
 import execa = require('execa');
 
 interface Command extends Array<any> {}
@@ -120,7 +118,7 @@ const prepareRelease = ({ dryrun, verbose }: any) =>
             console.log('skipping empty line');
           }
         }
-      } catch (ex) {
+      } catch (ex: any) {
         const err: string = ex.message;
         if (opts['okOnError'] && Array.isArray(opts['okOnError'])) {
           let trueError = true;
diff --git a/packages/grafana-toolkit/src/cli/tasks/plugin/bundle.managed.ts b/packages/grafana-toolkit/src/cli/tasks/plugin/bundle.managed.ts
index 2dafe879489..052c067a759 100644
--- a/packages/grafana-toolkit/src/cli/tasks/plugin/bundle.managed.ts
+++ b/packages/grafana-toolkit/src/cli/tasks/plugin/bundle.managed.ts
@@ -18,7 +18,7 @@ const bundleManagedPluginsRunner: TaskRunner<BundeManagedOptions> = async () =>
               console.log(`[${scope}]: ${plugin} building...`);
               await execa('yarn', ['build'], { cwd: `${MANAGED_PLUGINS_PATH}/${scope}/${plugin}` });
               console.log(`[${scope}]: ${plugin} bundled`);
-            } catch (e) {
+            } catch (e: any) {
               console.log(e.stdout);
             }
           }
diff --git a/packages/grafana-toolkit/src/cli/utils/githubRelease.ts b/packages/grafana-toolkit/src/cli/utils/githubRelease.ts
index 54df0ffba9c..a63a5609b52 100644
--- a/packages/grafana-toolkit/src/cli/utils/githubRelease.ts
+++ b/packages/grafana-toolkit/src/cli/utils/githubRelease.ts
@@ -3,8 +3,6 @@ import { getPluginJson } from '../../config/utils/pluginValidation';
 import { getCiFolder } from '../../plugins/env';
 import path = require('path');
 import fs = require('fs');
-// @ts-ignore
-// import execa = require('execa');
 import GithubClient from './githubClient';
 import { AxiosResponse } from 'axios';
 
@@ -79,7 +77,7 @@ class GitHubRelease {
       if (latestRelease.data.tag_name === `v${pluginInfo.version}`) {
         await this.git.client.delete(`releases/${latestRelease.data.id}`);
       }
-    } catch (reason) {
+    } catch (reason: any) {
       if (reason.response.status !== 404) {
         // 404 just means no release found. Not an error. Anything else though, re throw the error
         throw reason;
@@ -102,7 +100,7 @@ class GitHubRelease {
         `https://uploads.github.com/repos/${this.username}/${this.repository}/releases/${newReleaseResponse.data.id}/assets`
       );
       await Promise.all(publishPromises);
-    } catch (reason) {
+    } catch (reason: any) {
       console.error(reason.data?.message ?? reason.response.data ?? reason);
       // Rethrow the error so that we can trigger a non-zero exit code to circle-ci
       throw reason;
diff --git a/packages/grafana-toolkit/src/cli/utils/useSpinner.ts b/packages/grafana-toolkit/src/cli/utils/useSpinner.ts
index a80df432f52..6ba94e330c2 100644
--- a/packages/grafana-toolkit/src/cli/utils/useSpinner.ts
+++ b/packages/grafana-toolkit/src/cli/utils/useSpinner.ts
@@ -6,7 +6,7 @@ export const useSpinner = async (label: string, fn: () => Promise<any>, killProc
   try {
     await fn();
     spinner.succeed();
-  } catch (err) {
+  } catch (err: any) {
     spinner.fail(err.message || err);
 
     if (err.stdout) {
diff --git a/packages/grafana-toolkit/src/config/webpack.plugin.config.ts b/packages/grafana-toolkit/src/config/webpack.plugin.config.ts
index 9b1539a5acd..8f6a1809f80 100644
--- a/packages/grafana-toolkit/src/config/webpack.plugin.config.ts
+++ b/packages/grafana-toolkit/src/config/webpack.plugin.config.ts
@@ -274,7 +274,7 @@ export const loadWebpackConfig: WebpackConfigurationGetter = async (options) =>
       );
     }
     return (configGetter as CustomWebpackConfigurationGetter)(baseConfig, options);
-  } catch (err) {
+  } catch (err: any) {
     if (err.code === 'ENOENT') {
       return baseConfig;
     }
diff --git a/packages/grafana-toolkit/src/plugins/manifest.ts b/packages/grafana-toolkit/src/plugins/manifest.ts
index 66c5bff94f6..b06417df778 100644
--- a/packages/grafana-toolkit/src/plugins/manifest.ts
+++ b/packages/grafana-toolkit/src/plugins/manifest.ts
@@ -75,7 +75,7 @@ export async function signManifest(manifest: ManifestInfo): Promise<string> {
     }
 
     return info.data;
-  } catch (err) {
+  } catch (err: any) {
     if ((err.response && err.response.data) || err.response.data.message) {
       throw new Error('Error signing manifest: ' + err.response.data.message);
     }
diff --git a/packages/grafana-toolkit/tsconfig.json b/packages/grafana-toolkit/tsconfig.json
index b6c80bdbb7f..76f8cf95687 100644
--- a/packages/grafana-toolkit/tsconfig.json
+++ b/packages/grafana-toolkit/tsconfig.json
@@ -4,7 +4,8 @@
     "module": "commonjs",
     "outDir": "dist/src",
     "rootDirs": ["."],
-    "typeRoots": ["node_modules/@types"]
+    "typeRoots": ["node_modules/@types"],
+    "useUnknownInCatchVariables": false
   },
   "exclude": ["dist", "node_modules"],
   "extends": "@grafana/tsconfig",
diff --git a/packages/grafana-ui/package.json b/packages/grafana-ui/package.json
index a0f66f73b1a..59d424676d8 100644
--- a/packages/grafana-ui/package.json
+++ b/packages/grafana-ui/package.json
@@ -124,7 +124,7 @@
     "rollup-plugin-visualizer": "4.2.0",
     "storybook-dark-mode": "1.0.8",
     "ts-loader": "8.0.11",
-    "typescript": "4.3.4",
+    "typescript": "4.4.3",
     "webpack-filter-warnings-plugin": "1.2.1"
   },
   "types": "src/index.ts",
diff --git a/packages/grafana-ui/src/components/DataLinks/SelectionReference.ts b/packages/grafana-ui/src/components/DataLinks/SelectionReference.ts
index fa6964f1ee5..725ec3f2ce4 100644
--- a/packages/grafana-ui/src/components/DataLinks/SelectionReference.ts
+++ b/packages/grafana-ui/src/components/DataLinks/SelectionReference.ts
@@ -1,4 +1,6 @@
-export class SelectionReference {
+import { VirtualElement } from '@popperjs/core/lib/types';
+
+export class SelectionReference implements VirtualElement {
   getBoundingClientRect() {
     const selection = window.getSelection();
     const node = selection && selection.anchorNode;
@@ -15,7 +17,7 @@ export class SelectionReference {
       right: 0,
       width: 0,
       height: 0,
-    };
+    } as DOMRect;
   }
 
   get clientWidth() {
diff --git a/packages/jaeger-ui-components/package.json b/packages/jaeger-ui-components/package.json
index 586bc49ba61..14dcd78a14d 100644
--- a/packages/jaeger-ui-components/package.json
+++ b/packages/jaeger-ui-components/package.json
@@ -11,7 +11,7 @@
   "devDependencies": {
     "@wojtekmaj/enzyme-adapter-react-17": "0.6.2",
     "enzyme": "3.11.0",
-    "typescript": "4.3.4"
+    "typescript": "4.4.3"
   },
   "dependencies": {
     "@emotion/css": "11.1.3",
diff --git a/public/app/plugins/datasource/cloud-monitoring/components/LabelFilter.tsx b/public/app/plugins/datasource/cloud-monitoring/components/LabelFilter.tsx
index 45b64655bf1..1dd0b441721 100644
--- a/public/app/plugins/datasource/cloud-monitoring/components/LabelFilter.tsx
+++ b/public/app/plugins/datasource/cloud-monitoring/components/LabelFilter.tsx
@@ -20,14 +20,14 @@ const operators = ['=', '!=', '=~', '!=~'];
 
 const FilterButton = React.forwardRef<HTMLButtonElement, CustomControlProps<string>>(
   ({ value, isOpen, invalid, ...rest }, ref) => {
-    return <Button ref={ref} {...rest} variant="secondary" icon="plus"></Button>;
+    return <Button {...rest} ref={ref} variant="secondary" icon="plus"></Button>;
   }
 );
 FilterButton.displayName = 'FilterButton';
 
 const OperatorButton = React.forwardRef<HTMLButtonElement, CustomControlProps<string>>(({ value, ...rest }, ref) => {
   return (
-    <Button ref={ref} {...rest} variant="secondary">
+    <Button {...rest} ref={ref} variant="secondary">
       <span className="query-segment-operator">{value?.label}</span>
     </Button>
   );
diff --git a/tsconfig.json b/tsconfig.json
index e9e82570335..1143460287f 100644
--- a/tsconfig.json
+++ b/tsconfig.json
@@ -12,7 +12,8 @@
     "typeRoots": ["node_modules/@types", "public/app/types"],
     "allowJs": true,
     "strictNullChecks": true,
-    "resolveJsonModule": true
+    "resolveJsonModule": true,
+    "useUnknownInCatchVariables": false
   },
   "extends": "@grafana/tsconfig/base.json",
   "include": [
diff --git a/yarn.lock b/yarn.lock
index 21f574378a2..76c4f342ab3 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -23384,21 +23384,16 @@ tslib@2.0.1:
   resolved "https://registry.yarnpkg.com/tslib/-/tslib-2.0.1.tgz#410eb0d113e5b6356490eec749603725b021b43e"
   integrity sha512-SgIkNheinmEBgx1IUNirK0TUD4X9yjjBRTqqjggWCU3pUEqIk3/Uwl3yRixYKT6WjQuGiwDv4NomL3wqRCj+CQ==
 
-tslib@2.2.0:
-  version "2.2.0"
-  resolved "https://registry.yarnpkg.com/tslib/-/tslib-2.2.0.tgz#fb2c475977e35e241311ede2693cee1ec6698f5c"
-  integrity sha512-gS9GVHRU+RGn5KQM2rllAlR3dU6m7AcpJKdtH8gFvQiC4Otgk98XnmMU+nZenHt/+VhnBPWwgrJsyrdcw6i23w==
+tslib@2.3.1, tslib@^2.0.0, tslib@^2.0.1, tslib@^2.0.3, tslib@^2.1.0, tslib@^2.2.0, tslib@^2.3.0:
+  version "2.3.1"
+  resolved "https://registry.yarnpkg.com/tslib/-/tslib-2.3.1.tgz#e8a335add5ceae51aa261d32a490158ef042ef01"
+  integrity sha512-77EbyPPpMz+FRFRuAFlWMtmgUWGe9UOG2Z25NqCwiIjRhOf5iKGuzSe5P2w1laq+FkRy4p+PCuVkJSGkzTEKVw==
 
 tslib@^1.10.0, tslib@^1.8.1, tslib@^1.9.0, tslib@^1.9.3:
   version "1.14.1"
   resolved "https://registry.yarnpkg.com/tslib/-/tslib-1.14.1.tgz#cf2d38bdc34a134bcaf1091c41f6619e2f672d00"
   integrity sha512-Xni35NKzjgMrwevysHTCArtLDpPvye8zV/0E4EyYn43P7/7qvQwPh9BGkHewbMulVntbigmcT7rdX3BNo9wRJg==
 
-tslib@^2.0.0, tslib@^2.0.1, tslib@^2.0.3, tslib@^2.1.0, tslib@^2.2.0, tslib@^2.3.0:
-  version "2.3.1"
-  resolved "https://registry.yarnpkg.com/tslib/-/tslib-2.3.1.tgz#e8a335add5ceae51aa261d32a490158ef042ef01"
-  integrity sha512-77EbyPPpMz+FRFRuAFlWMtmgUWGe9UOG2Z25NqCwiIjRhOf5iKGuzSe5P2w1laq+FkRy4p+PCuVkJSGkzTEKVw==
-
 tslib@~2.1.0:
   version "2.1.0"
   resolved "https://registry.yarnpkg.com/tslib/-/tslib-2.1.0.tgz#da60860f1c2ecaa5703ab7d39bc05b6bf988b97a"
@@ -23529,6 +23524,11 @@ typescript@4.3.4:
   resolved "https://registry.yarnpkg.com/typescript/-/typescript-4.3.4.tgz#3f85b986945bcf31071decdd96cf8bfa65f9dcbc"
   integrity sha512-uauPG7XZn9F/mo+7MrsRjyvbxFpzemRjKEZXS4AK83oP2KKOJPvb+9cO/gmnv8arWZvhnjVOXz7B49m1l0e9Ew==
 
+typescript@4.4.3:
+  version "4.4.3"
+  resolved "https://registry.yarnpkg.com/typescript/-/typescript-4.4.3.tgz#bdc5407caa2b109efd4f82fe130656f977a29324"
+  integrity sha512-4xfscpisVgqqDfPaJo5vkd+Qd/ItkoagnHpufr+i2QCHBsNYp+G7UAoyFl8aPtx879u38wPV65rZ8qbGZijalA==
+
 typescript@~3.9.7:
   version "3.9.7"
   resolved "https://registry.yarnpkg.com/typescript/-/typescript-3.9.7.tgz#98d600a5ebdc38f40cb277522f12dc800e9e25fa"