diff --git a/packages/grafana-data/src/types/datasource.ts b/packages/grafana-data/src/types/datasource.ts
index c33328eb24e..64c4151af46 100644
--- a/packages/grafana-data/src/types/datasource.ts
+++ b/packages/grafana-data/src/types/datasource.ts
@@ -530,6 +530,7 @@ export interface DataSourceJsonData {
   defaultRegion?: string;
   profile?: string;
   manageAlerts?: boolean;
+  alertmanagerUid?: string;
 }
 
 /**
diff --git a/packages/grafana-ui/src/components/DataSourceSettings/AlertingSettings.tsx b/packages/grafana-ui/src/components/DataSourceSettings/AlertingSettings.tsx
index 28be8654425..79135144cbd 100644
--- a/packages/grafana-ui/src/components/DataSourceSettings/AlertingSettings.tsx
+++ b/packages/grafana-ui/src/components/DataSourceSettings/AlertingSettings.tsx
@@ -1,13 +1,34 @@
-import { DataSourcePluginOptionsEditorProps } from '@grafana/data';
-import React from 'react';
+import { DataSourceInstanceSettings, DataSourceJsonData, DataSourcePluginOptionsEditorProps } from '@grafana/data';
+import React, { useMemo } from 'react';
 import { Switch } from '../Forms/Legacy/Switch/Switch';
+import { InlineField } from '../Forms/InlineField';
+import { InlineFieldRow } from '../Forms/InlineFieldRow';
+import { Select } from '../Select/Select';
 
-type Props<T> = Pick<DataSourcePluginOptionsEditorProps<T>, 'options' | 'onOptionsChange'>;
+interface Props<T> extends Pick<DataSourcePluginOptionsEditorProps<T>, 'options' | 'onOptionsChange'> {
+  alertmanagerDataSources: Array<DataSourceInstanceSettings<DataSourceJsonData>>;
+}
 
-export function AlertingSettings<T extends { manageAlerts?: boolean }>({
+interface AlertingConfig extends DataSourceJsonData {
+  manageAlerts?: boolean;
+}
+
+export function AlertingSettings<T extends AlertingConfig>({
+  alertmanagerDataSources,
   options,
   onOptionsChange,
 }: Props<T>): JSX.Element {
+  const alertmanagerOptions = useMemo(
+    () =>
+      alertmanagerDataSources.map((ds) => ({
+        label: ds.name,
+        value: ds.uid,
+        imgUrl: ds.meta.info.logos.small,
+        meta: ds.meta,
+      })),
+    [alertmanagerDataSources]
+  );
+
   return (
     <>
       <h3 className="page-heading">Alerting</h3>
@@ -27,6 +48,23 @@ export function AlertingSettings<T extends { manageAlerts?: boolean }>({
             />
           </div>
         </div>
+        <InlineFieldRow>
+          <InlineField
+            tooltip="The alertmanager that manages alerts for this data source"
+            label="Alertmanager data source"
+            labelWidth={26}
+          >
+            <Select
+              width={29}
+              menuShouldPortal
+              options={alertmanagerOptions}
+              onChange={(value) =>
+                onOptionsChange({ ...options, jsonData: { ...options.jsonData, alertmanagerUid: value?.value } })
+              }
+              value={options.jsonData.alertmanagerUid}
+            />
+          </InlineField>
+        </InlineFieldRow>
       </div>
     </>
   );
diff --git a/public/app/features/alerting/unified/components/rules/RuleDetailsActionButtons.tsx b/public/app/features/alerting/unified/components/rules/RuleDetailsActionButtons.tsx
index a63ff28d7a4..d5d24b02fa8 100644
--- a/public/app/features/alerting/unified/components/rules/RuleDetailsActionButtons.tsx
+++ b/public/app/features/alerting/unified/components/rules/RuleDetailsActionButtons.tsx
@@ -9,11 +9,12 @@ import { contextSrv } from 'app/core/services/context_srv';
 import { appEvents } from 'app/core/core';
 import { useIsRuleEditable } from '../../hooks/useIsRuleEditable';
 import { Annotation } from '../../utils/constants';
-import { getRulesSourceName, isCloudRulesSource } from '../../utils/datasource';
-import { createExploreLink, createViewLink } from '../../utils/misc';
+import { getRulesSourceName, isCloudRulesSource, isGrafanaRulesSource } from '../../utils/datasource';
+import { createExploreLink, createViewLink, makeSilenceLink } from '../../utils/misc';
 import * as ruleId from '../../utils/rule-id';
 import { deleteRuleAction } from '../../state/actions';
 import { CombinedRule, RulesSource } from 'app/types/unified-alerting';
+import { getAlertmanagerByUid } from '../../utils/alertmanager';
 
 interface Props {
   rule: CombinedRule;
@@ -27,6 +28,10 @@ export const RuleDetailsActionButtons: FC<Props> = ({ rule, rulesSource }) => {
   const { namespace, group, rulerRule } = rule;
   const [ruleToDelete, setRuleToDelete] = useState<CombinedRule>();
 
+  const alertmanagerSourceName = isGrafanaRulesSource(rulesSource)
+    ? rulesSource
+    : getAlertmanagerByUid(rulesSource.jsonData.alertmanagerUid)?.name;
+
   const leftButtons: JSX.Element[] = [];
   const rightButtons: JSX.Element[] = [];
 
@@ -123,6 +128,21 @@ export const RuleDetailsActionButtons: FC<Props> = ({ rule, rulesSource }) => {
     }
   }
 
+  if (alertmanagerSourceName) {
+    leftButtons.push(
+      <LinkButton
+        className={style.button}
+        size="xs"
+        key="silence"
+        icon="bell-slash"
+        target="__blank"
+        href={makeSilenceLink(alertmanagerSourceName, rule)}
+      >
+        Silence
+      </LinkButton>
+    );
+  }
+
   if (!isViewMode) {
     rightButtons.push(
       <LinkButton
diff --git a/public/app/features/alerting/unified/utils/alertmanager.ts b/public/app/features/alerting/unified/utils/alertmanager.ts
index 1ded7b86c94..117ec24750d 100644
--- a/public/app/features/alerting/unified/utils/alertmanager.ts
+++ b/public/app/features/alerting/unified/utils/alertmanager.ts
@@ -2,6 +2,8 @@ import { AlertManagerCortexConfig, MatcherOperator, Route, Matcher } from 'app/p
 import { Labels } from 'app/types/unified-alerting-dto';
 import { MatcherFieldValue } from '../types/silence-form';
 import { SelectableValue } from '@grafana/data';
+import { getAllDataSources } from './config';
+import { DataSourceType } from './datasource';
 
 export function addDefaultsToAlertmanagerConfig(config: AlertManagerCortexConfig): AlertManagerCortexConfig {
   // add default receiver if it does not exist
@@ -174,3 +176,11 @@ export function labelsMatchMatchers(labels: Labels, matchers: Matcher[]): boolea
     });
   });
 }
+
+export function getAllAlertmanagerDataSources() {
+  return getAllDataSources().filter((ds) => ds.type === DataSourceType.Alertmanager);
+}
+
+export function getAlertmanagerByUid(uid?: string) {
+  return getAllAlertmanagerDataSources().find((ds) => uid === ds.uid);
+}
diff --git a/public/app/features/alerting/unified/utils/misc.ts b/public/app/features/alerting/unified/utils/misc.ts
index 946f064e9fa..813c3143f0c 100644
--- a/public/app/features/alerting/unified/utils/misc.ts
+++ b/public/app/features/alerting/unified/utils/misc.ts
@@ -57,6 +57,15 @@ export function makeAMLink(path: string, alertManagerName?: string): string {
   return `${path}${alertManagerName ? `?${ALERTMANAGER_NAME_QUERY_KEY}=${encodeURIComponent(alertManagerName)}` : ''}`;
 }
 
+export function makeSilenceLink(alertmanagerSourceName: string, rule: CombinedRule) {
+  return (
+    `${config.appSubUrl}/alerting/silence/new?alertmanager=${alertmanagerSourceName}` +
+    `&matchers=alertname=${rule.name},${Object.entries(rule.labels)
+      .map(([key, value]) => encodeURIComponent(`${key}=${value}`))
+      .join(',')}`
+  );
+}
+
 // keep retrying fn if it's error passes shouldRetry(error) and timeout has not elapsed yet
 export function retryWhile<T, E = Error>(
   fn: () => Promise<T>,
diff --git a/public/app/plugins/datasource/loki/configuration/ConfigEditor.tsx b/public/app/plugins/datasource/loki/configuration/ConfigEditor.tsx
index d8121b732d3..99b8a6c3853 100644
--- a/public/app/plugins/datasource/loki/configuration/ConfigEditor.tsx
+++ b/public/app/plugins/datasource/loki/configuration/ConfigEditor.tsx
@@ -4,6 +4,7 @@ import { AlertingSettings, DataSourceHttpSettings } from '@grafana/ui';
 import { LokiOptions } from '../types';
 import { MaxLinesField } from './MaxLinesField';
 import { DerivedFields } from './DerivedFields';
+import { getAllAlertmanagerDataSources } from 'app/features/alerting/unified/utils/alertmanager';
 
 export type Props = DataSourcePluginOptionsEditorProps<LokiOptions>;
 
@@ -25,6 +26,7 @@ const setDerivedFields = makeJsonUpdater('derivedFields');
 
 export const ConfigEditor = (props: Props) => {
   const { options, onOptionsChange } = props;
+  const alertmanagers = getAllAlertmanagerDataSources();
 
   return (
     <>
@@ -35,7 +37,11 @@ export const ConfigEditor = (props: Props) => {
         onChange={onOptionsChange}
       />
 
-      <AlertingSettings<LokiOptions> options={options} onOptionsChange={onOptionsChange} />
+      <AlertingSettings<LokiOptions>
+        alertmanagerDataSources={alertmanagers}
+        options={options}
+        onOptionsChange={onOptionsChange}
+      />
 
       <div className="gf-form-group">
         <div className="gf-form-inline">
diff --git a/public/app/plugins/datasource/loki/types.ts b/public/app/plugins/datasource/loki/types.ts
index 4de1f31a68f..b31b09c9690 100644
--- a/public/app/plugins/datasource/loki/types.ts
+++ b/public/app/plugins/datasource/loki/types.ts
@@ -38,6 +38,7 @@ export interface LokiQuery extends DataQuery {
 export interface LokiOptions extends DataSourceJsonData {
   maxLines?: string;
   derivedFields?: DerivedFieldConfig[];
+  alertmanager?: string;
 }
 
 export interface LokiStats {
diff --git a/public/app/plugins/datasource/prometheus/configuration/ConfigEditor.tsx b/public/app/plugins/datasource/prometheus/configuration/ConfigEditor.tsx
index f3e6361f1bd..9a63f2e3a68 100644
--- a/public/app/plugins/datasource/prometheus/configuration/ConfigEditor.tsx
+++ b/public/app/plugins/datasource/prometheus/configuration/ConfigEditor.tsx
@@ -5,10 +5,12 @@ import { config } from 'app/core/config';
 import { PromOptions } from '../types';
 import { AzureAuthSettings } from './AzureAuthSettings';
 import { PromSettings } from './PromSettings';
+import { getAllAlertmanagerDataSources } from 'app/features/alerting/unified/utils/alertmanager';
 
 export type Props = DataSourcePluginOptionsEditorProps<PromOptions>;
 export const ConfigEditor = (props: Props) => {
   const { options, onOptionsChange } = props;
+  const alertmanagers = getAllAlertmanagerDataSources();
 
   const azureAuthSettings = {
     azureAuthEnabled: config.featureToggles['prometheus_azure_auth'] ?? false,
@@ -32,7 +34,11 @@ export const ConfigEditor = (props: Props) => {
         azureAuthSettings={azureAuthSettings}
       />
 
-      <AlertingSettings<PromOptions> options={options} onOptionsChange={onOptionsChange} />
+      <AlertingSettings<PromOptions>
+        alertmanagerDataSources={alertmanagers}
+        options={options}
+        onOptionsChange={onOptionsChange}
+      />
 
       <PromSettings options={options} onOptionsChange={onOptionsChange} />
     </>