diff --git a/public/app/features/plugins/sandbox/document_sandbox.ts b/public/app/features/plugins/sandbox/document_sandbox.ts
index e0750a9a785..12fd4853e1e 100644
--- a/public/app/features/plugins/sandbox/document_sandbox.ts
+++ b/public/app/features/plugins/sandbox/document_sandbox.ts
@@ -1,6 +1,7 @@
-import { ProxyTarget } from '@locker/near-membrane-shared';
+import { isNearMembraneProxy, ProxyTarget } from '@locker/near-membrane-shared';
 
 import { forbiddenElements } from './constants';
+import { isReactClassComponent } from './utils';
 
 // IMPORTANT: NEVER export this symbol from a public (e.g `@grafana/*`) package
 const SANDBOX_LIVE_VALUE = Symbol.for('@@SANDBOX_LIVE_VALUE');
@@ -72,6 +73,31 @@ export function markDomElementStyleAsALiveTarget(el: Element) {
   }
 }
 
+/**
+ * Some specific near membrane proxies interfere with plugins
+ * an example of this is React class components state and their fast life cycles
+ * with cached objects.
+ *
+ * This function marks an object as a live target inside the sandbox
+ * but not all objects, only the ones that are allowed to be modified
+ */
+export function patchObjectAsLiveTarget(obj: unknown) {
+  if (
+    obj &&
+    // do not define it twice
+    !Object.hasOwn(obj, SANDBOX_LIVE_VALUE) &&
+    // only for proxies
+    isNearMembraneProxy(obj) &&
+    // do not patch functions
+    !(obj instanceof Function) &&
+    // conditions for allowed objects
+    // react class components
+    isReactClassComponent(obj)
+  ) {
+    Reflect.defineProperty(obj, SANDBOX_LIVE_VALUE, {});
+  }
+}
+
 export function isLiveTarget(el: ProxyTarget) {
   return Object.hasOwn(el, SANDBOX_LIVE_VALUE);
 }
diff --git a/public/app/features/plugins/sandbox/sandbox_plugin_loader.ts b/public/app/features/plugins/sandbox/sandbox_plugin_loader.ts
index f66209b2cde..89c3746307a 100644
--- a/public/app/features/plugins/sandbox/sandbox_plugin_loader.ts
+++ b/public/app/features/plugins/sandbox/sandbox_plugin_loader.ts
@@ -11,6 +11,7 @@ import {
   isDomElement,
   isLiveTarget,
   markDomElementStyleAsALiveTarget,
+  patchObjectAsLiveTarget,
 } from './document_sandbox';
 import { sandboxPluginDependencies } from './plugin_dependencies';
 import { sandboxPluginComponents } from './sandbox_components';
@@ -48,6 +49,8 @@ async function doImportPluginModuleInSandbox(meta: PluginMeta): Promise<unknown>
       // the element.style attribute should be a live target to work in chrome
       markDomElementStyleAsALiveTarget(element);
       return element;
+    } else {
+      patchObjectAsLiveTarget(originalValue);
     }
     const distortion = generalDistortionMap.get(originalValue);
     if (distortion) {
diff --git a/public/app/features/plugins/sandbox/utils.ts b/public/app/features/plugins/sandbox/utils.ts
index 78c8073746a..21237b7d4c2 100644
--- a/public/app/features/plugins/sandbox/utils.ts
+++ b/public/app/features/plugins/sandbox/utils.ts
@@ -1,3 +1,5 @@
+import React from 'react';
+
 import { SandboxedPluginObject } from './types';
 
 export function isSandboxedPluginObject(value: unknown): value is SandboxedPluginObject {
@@ -7,3 +9,7 @@ export function isSandboxedPluginObject(value: unknown): value is SandboxedPlugi
 export function assertNever(x: never): never {
   throw new Error(`Unexpected object: ${x}. This should never happen.`);
 }
+
+export function isReactClassComponent(obj: unknown): obj is React.Component {
+  return obj instanceof React.Component;
+}