diff --git a/packages/grafana-ui/src/components/Table/FilterableTableCell.tsx b/packages/grafana-ui/src/components/Table/FilterableTableCell.tsx
new file mode 100644
index 00000000000..fa1962d5ba2
--- /dev/null
+++ b/packages/grafana-ui/src/components/Table/FilterableTableCell.tsx
@@ -0,0 +1,86 @@
+import React, { FC, useCallback, useState } from 'react';
+import { TableCellProps } from 'react-table';
+import { GrafanaTheme } from '@grafana/data';
+import { css, cx } from 'emotion';
+
+import { stylesFactory, useTheme } from '../../themes';
+import { TableStyles } from './styles';
+import { FILTER_FOR_OPERATOR, FILTER_OUT_OPERATOR, TableFilterActionCallback } from './types';
+import { Icon, Tooltip } from '..';
+import { Props, renderCell } from './TableCell';
+
+interface FilterableTableCellProps extends Pick<Props, 'cell' | 'field' | 'tableStyles'> {
+  onCellFilterAdded: TableFilterActionCallback;
+  cellProps: TableCellProps;
+}
+
+export const FilterableTableCell: FC<FilterableTableCellProps> = ({
+  cell,
+  field,
+  tableStyles,
+  onCellFilterAdded,
+  cellProps,
+}) => {
+  const [showFilters, setShowFilter] = useState(false);
+  const onMouseOver = useCallback((event: React.MouseEvent<HTMLDivElement>) => setShowFilter(true), [setShowFilter]);
+  const onMouseLeave = useCallback((event: React.MouseEvent<HTMLDivElement>) => setShowFilter(false), [setShowFilter]);
+  const onFilterFor = useCallback(
+    (event: React.MouseEvent<HTMLDivElement>) =>
+      onCellFilterAdded({ key: field.name, operator: FILTER_FOR_OPERATOR, value: cell.value }),
+    [cell, field, onCellFilterAdded]
+  );
+  const onFilterOut = useCallback(
+    (event: React.MouseEvent<HTMLDivElement>) =>
+      onCellFilterAdded({ key: field.name, operator: FILTER_OUT_OPERATOR, value: cell.value }),
+    [cell, field, onCellFilterAdded]
+  );
+  const theme = useTheme();
+  const styles = getFilterableTableCellStyles(theme, tableStyles);
+
+  return (
+    <div
+      {...cellProps}
+      className={showFilters ? styles.tableCellWrapper : tableStyles.tableCellWrapper}
+      onMouseOver={onMouseOver}
+      onMouseLeave={onMouseLeave}
+    >
+      {renderCell(cell, field, tableStyles)}
+      {showFilters && cell.value && (
+        <div className={styles.filterWrapper}>
+          <div className={styles.filterItem}>
+            <Tooltip content="Filter for value" placement="top">
+              <Icon name={'search-plus'} onClick={onFilterFor} />
+            </Tooltip>
+          </div>
+          <div className={styles.filterItem}>
+            <Tooltip content="Filter out value" placement="top">
+              <Icon name={'search-minus'} onClick={onFilterOut} />
+            </Tooltip>
+          </div>
+        </div>
+      )}
+    </div>
+  );
+};
+
+const getFilterableTableCellStyles = stylesFactory((theme: GrafanaTheme, tableStyles: TableStyles) => ({
+  tableCellWrapper: cx(
+    tableStyles.tableCellWrapper,
+    css`
+      display: inline-flex;
+      justify-content: space-between;
+      align-items: center;
+    `
+  ),
+  filterWrapper: css`
+    label: filterWrapper;
+    display: inline-flex;
+    justify-content: space-around;
+    cursor: pointer;
+  `,
+  filterItem: css`
+    label: filterItem;
+    color: ${theme.colors.textSemiWeak};
+    padding: 0 ${theme.spacing.xxs};
+  `,
+}));
diff --git a/packages/grafana-ui/src/components/Table/Table.tsx b/packages/grafana-ui/src/components/Table/Table.tsx
index ce234702e25..25e71483cf1 100644
--- a/packages/grafana-ui/src/components/Table/Table.tsx
+++ b/packages/grafana-ui/src/components/Table/Table.tsx
@@ -36,9 +36,9 @@ export interface Props {
   noHeader?: boolean;
   resizable?: boolean;
   initialSortBy?: TableSortByFieldState[];
-  onCellClick?: TableFilterActionCallback;
   onColumnResize?: TableColumnResizeActionCallback;
   onSortByChange?: TableSortByActionCallback;
+  onCellFilterAdded?: TableFilterActionCallback;
 }
 
 interface ReactTableInternalState extends UseResizeColumnsState<{}>, UseSortByState<{}> {}
@@ -110,7 +110,15 @@ function getInitialState(props: Props, columns: Column[]): Partial<ReactTableInt
 }
 
 export const Table: FC<Props> = memo((props: Props) => {
-  const { data, height, onCellClick, width, columnMinWidth = COLUMN_MIN_WIDTH, noHeader, resizable = true } = props;
+  const {
+    data,
+    height,
+    onCellFilterAdded,
+    width,
+    columnMinWidth = COLUMN_MIN_WIDTH,
+    noHeader,
+    resizable = true,
+  } = props;
   const theme = useTheme();
   const tableStyles = getTableStyles(theme);
 
@@ -162,7 +170,7 @@ export const Table: FC<Props> = memo((props: Props) => {
               field={data.fields[index]}
               tableStyles={tableStyles}
               cell={cell}
-              onCellClick={onCellClick}
+              onCellFilterAdded={onCellFilterAdded}
             />
           ))}
         </div>
diff --git a/packages/grafana-ui/src/components/Table/TableCell.tsx b/packages/grafana-ui/src/components/Table/TableCell.tsx
index 2b4c4909c1b..ae9796c4d8d 100644
--- a/packages/grafana-ui/src/components/Table/TableCell.tsx
+++ b/packages/grafana-ui/src/components/Table/TableCell.tsx
@@ -1,38 +1,45 @@
 import React, { FC } from 'react';
 import { Cell } from 'react-table';
 import { Field } from '@grafana/data';
+
 import { getTextAlign } from './utils';
 import { TableFilterActionCallback } from './types';
 import { TableStyles } from './styles';
+import { FilterableTableCell } from './FilterableTableCell';
 
-interface Props {
+export interface Props {
   cell: Cell;
   field: Field;
   tableStyles: TableStyles;
-  onCellClick?: TableFilterActionCallback;
+  onCellFilterAdded?: TableFilterActionCallback;
 }
 
-export const TableCell: FC<Props> = ({ cell, field, tableStyles, onCellClick }) => {
+export const TableCell: FC<Props> = ({ cell, field, tableStyles, onCellFilterAdded }) => {
   const filterable = field.config.filterable;
   const cellProps = cell.getCellProps();
 
-  let onClick: ((event: React.SyntheticEvent) => void) | undefined = undefined;
-
-  if (filterable && onCellClick) {
-    if (cellProps.style) {
-      cellProps.style.cursor = 'pointer';
-    }
-
-    onClick = () => onCellClick(cell.column.Header as string, cell.value);
-  }
-
   if (cellProps.style) {
     cellProps.style.textAlign = getTextAlign(field);
   }
 
+  if (filterable && onCellFilterAdded) {
+    return (
+      <FilterableTableCell
+        cell={cell}
+        field={field}
+        tableStyles={tableStyles}
+        onCellFilterAdded={onCellFilterAdded}
+        cellProps={cellProps}
+      />
+    );
+  }
+
   return (
-    <div {...cellProps} onClick={onClick} className={tableStyles.tableCellWrapper}>
-      {cell.render('Cell', { field, tableStyles })}
+    <div {...cellProps} className={tableStyles.tableCellWrapper}>
+      {renderCell(cell, field, tableStyles)}
     </div>
   );
 };
+
+export const renderCell = (cell: Cell, field: Field, tableStyles: TableStyles) =>
+  cell.render('Cell', { field, tableStyles });
diff --git a/packages/grafana-ui/src/components/Table/types.ts b/packages/grafana-ui/src/components/Table/types.ts
index c599f941123..687c9e60295 100644
--- a/packages/grafana-ui/src/components/Table/types.ts
+++ b/packages/grafana-ui/src/components/Table/types.ts
@@ -25,7 +25,11 @@ export interface TableRow {
   [x: string]: any;
 }
 
-export type TableFilterActionCallback = (key: string, value: string) => void;
+export const FILTER_FOR_OPERATOR = '=';
+export const FILTER_OUT_OPERATOR = '!=';
+export type FilterOperator = typeof FILTER_FOR_OPERATOR | typeof FILTER_OUT_OPERATOR;
+export type FilterItem = { key: string; value: string; operator: FilterOperator };
+export type TableFilterActionCallback = (item: FilterItem) => void;
 export type TableColumnResizeActionCallback = (fieldDisplayName: string, width: number) => void;
 export type TableSortByActionCallback = (state: TableSortByFieldState[]) => void;
 
diff --git a/public/app/features/explore/Explore.tsx b/public/app/features/explore/Explore.tsx
index be4287ceae7..bda92fd476b 100644
--- a/public/app/features/explore/Explore.tsx
+++ b/public/app/features/explore/Explore.tsx
@@ -58,6 +58,7 @@ import { scanStopAction } from './state/actionTypes';
 import { ExploreGraphPanel } from './ExploreGraphPanel';
 import { TraceView } from './TraceView/TraceView';
 import { SecondaryActions } from './SecondaryActions';
+import { FILTER_FOR_OPERATOR, FILTER_OUT_OPERATOR, FilterItem } from '@grafana/ui/src/components/Table/types';
 
 const getStyles = stylesFactory((theme: GrafanaTheme) => {
   return {
@@ -211,6 +212,17 @@ export class Explore extends React.PureComponent<ExploreProps, ExploreState> {
     this.props.setQueries(this.props.exploreId, [query]);
   };
 
+  onCellFilterAdded = (filter: FilterItem) => {
+    const { value, key, operator } = filter;
+    if (operator === FILTER_FOR_OPERATOR) {
+      this.onClickFilterLabel(key, value);
+    }
+
+    if (operator === FILTER_OUT_OPERATOR) {
+      this.onClickFilterOutLabel(key, value);
+    }
+  };
+
   onClickFilterLabel = (key: string, value: string) => {
     this.onModifyQueries({ type: 'ADD_FILTER', key, value });
   };
@@ -366,7 +378,13 @@ export class Explore extends React.PureComponent<ExploreProps, ExploreState> {
                             />
                           )}
                           {mode === ExploreMode.Metrics && (
-                            <TableContainer width={width} exploreId={exploreId} onClickCell={this.onClickFilterLabel} />
+                            <TableContainer
+                              width={width}
+                              exploreId={exploreId}
+                              onCellFilterAdded={
+                                this.props.datasourceInstance?.modifyQuery ? this.onCellFilterAdded : undefined
+                              }
+                            />
                           )}
                           {mode === ExploreMode.Logs && (
                             <LogsContainer
diff --git a/public/app/features/explore/TableContainer.test.tsx b/public/app/features/explore/TableContainer.test.tsx
index 1f79150435c..302f44074cb 100644
--- a/public/app/features/explore/TableContainer.test.tsx
+++ b/public/app/features/explore/TableContainer.test.tsx
@@ -1,5 +1,5 @@
 import React from 'react';
-import { shallow, render } from 'enzyme';
+import { render, shallow } from 'enzyme';
 import { TableContainer } from './TableContainer';
 import { DataFrame } from '@grafana/data';
 import { toggleTable } from './state/actions';
@@ -11,7 +11,7 @@ describe('TableContainer', () => {
       exploreId: ExploreId.left as ExploreId,
       loading: false,
       width: 800,
-      onClickCell: jest.fn(),
+      onCellFilterAdded: jest.fn(),
       showingTable: true,
       tableResult: {} as DataFrame,
       toggleTable: {} as typeof toggleTable,
@@ -26,7 +26,7 @@ describe('TableContainer', () => {
       exploreId: ExploreId.left as ExploreId,
       loading: false,
       width: 800,
-      onClickCell: jest.fn(),
+      onCellFilterAdded: jest.fn(),
       showingTable: true,
       tableResult: {
         name: 'TableResultName',
diff --git a/public/app/features/explore/TableContainer.tsx b/public/app/features/explore/TableContainer.tsx
index 2c75bf3c476..c7539f0c301 100644
--- a/public/app/features/explore/TableContainer.tsx
+++ b/public/app/features/explore/TableContainer.tsx
@@ -2,19 +2,20 @@ import React, { PureComponent } from 'react';
 import { hot } from 'react-hot-loader';
 import { connect } from 'react-redux';
 import { DataFrame } from '@grafana/data';
-import { Table, Collapse } from '@grafana/ui';
+import { Collapse, Table } from '@grafana/ui';
 import { ExploreId, ExploreItemState } from 'app/types/explore';
 import { StoreState } from 'app/types';
 import { toggleTable } from './state/actions';
 import { config } from 'app/core/config';
 import { PANEL_BORDER } from 'app/core/constants';
 import { MetaInfoText } from './MetaInfoText';
+import { FilterItem } from '@grafana/ui/src/components/Table/types';
 
 interface TableContainerProps {
   exploreId: ExploreId;
   loading: boolean;
   width: number;
-  onClickCell: (key: string, value: string) => void;
+  onCellFilterAdded?: (filter: FilterItem) => void;
   showingTable: boolean;
   tableResult?: DataFrame;
   toggleTable: typeof toggleTable;
@@ -37,7 +38,7 @@ export class TableContainer extends PureComponent<TableContainerProps> {
   }
 
   render() {
-    const { loading, onClickCell, showingTable, tableResult, width } = this.props;
+    const { loading, onCellFilterAdded, showingTable, tableResult, width } = this.props;
 
     const height = this.getTableHeight();
     const tableWidth = width - config.theme.panelPadding * 2 - PANEL_BORDER;
@@ -46,7 +47,7 @@ export class TableContainer extends PureComponent<TableContainerProps> {
     return (
       <Collapse label="Table" loading={loading} collapsible isOpen={showingTable} onToggle={this.onClickTableButton}>
         {hasTableResult ? (
-          <Table data={tableResult!} width={tableWidth} height={height} onCellClick={onClickCell} />
+          <Table data={tableResult!} width={tableWidth} height={height} onCellFilterAdded={onCellFilterAdded} />
         ) : (
           <MetaInfoText metaItems={[{ value: '0 series returned' }]} />
         )}
diff --git a/public/app/plugins/datasource/prometheus/datasource.test.ts b/public/app/plugins/datasource/prometheus/datasource.test.ts
index c20c19cd14a..e490818ed4f 100644
--- a/public/app/plugins/datasource/prometheus/datasource.test.ts
+++ b/public/app/plugins/datasource/prometheus/datasource.test.ts
@@ -20,6 +20,7 @@ import { PromOptions, PromQuery } from './types';
 import templateSrv from 'app/features/templating/template_srv';
 import { getTimeSrv, TimeSrv } from 'app/features/dashboard/services/TimeSrv';
 import { VariableHide } from '../../../features/variables/types';
+import { describe } from '../../../../test/lib/common';
 
 const datasourceRequestMock = jest.fn().mockResolvedValue(createDefaultPromResponse());
 
@@ -1886,6 +1887,68 @@ describe('prepareTargets', () => {
   });
 });
 
+describe('modifyQuery', () => {
+  describe('when called with ADD_FILTER', () => {
+    describe('and query has no labels', () => {
+      it('then the correct label should be added', () => {
+        const query: PromQuery = { refId: 'A', expr: 'go_goroutines' };
+        const action = { key: 'cluster', value: 'us-cluster', type: 'ADD_FILTER' };
+        const instanceSettings = ({ jsonData: {} } as unknown) as DataSourceInstanceSettings<PromOptions>;
+        const ds = new PrometheusDatasource(instanceSettings);
+
+        const result = ds.modifyQuery(query, action);
+
+        expect(result.refId).toEqual('A');
+        expect(result.expr).toEqual('go_goroutines{cluster="us-cluster"}');
+      });
+    });
+
+    describe('and query has labels', () => {
+      it('then the correct label should be added', () => {
+        const query: PromQuery = { refId: 'A', expr: 'go_goroutines{cluster="us-cluster"}' };
+        const action = { key: 'pod', value: 'pod-123', type: 'ADD_FILTER' };
+        const instanceSettings = ({ jsonData: {} } as unknown) as DataSourceInstanceSettings<PromOptions>;
+        const ds = new PrometheusDatasource(instanceSettings);
+
+        const result = ds.modifyQuery(query, action);
+
+        expect(result.refId).toEqual('A');
+        expect(result.expr).toEqual('go_goroutines{cluster="us-cluster",pod="pod-123"}');
+      });
+    });
+  });
+
+  describe('when called with ADD_FILTER_OUT', () => {
+    describe('and query has no labels', () => {
+      it('then the correct label should be added', () => {
+        const query: PromQuery = { refId: 'A', expr: 'go_goroutines' };
+        const action = { key: 'cluster', value: 'us-cluster', type: 'ADD_FILTER_OUT' };
+        const instanceSettings = ({ jsonData: {} } as unknown) as DataSourceInstanceSettings<PromOptions>;
+        const ds = new PrometheusDatasource(instanceSettings);
+
+        const result = ds.modifyQuery(query, action);
+
+        expect(result.refId).toEqual('A');
+        expect(result.expr).toEqual('go_goroutines{cluster!="us-cluster"}');
+      });
+    });
+
+    describe('and query has labels', () => {
+      it('then the correct label should be added', () => {
+        const query: PromQuery = { refId: 'A', expr: 'go_goroutines{cluster="us-cluster"}' };
+        const action = { key: 'pod', value: 'pod-123', type: 'ADD_FILTER_OUT' };
+        const instanceSettings = ({ jsonData: {} } as unknown) as DataSourceInstanceSettings<PromOptions>;
+        const ds = new PrometheusDatasource(instanceSettings);
+
+        const result = ds.modifyQuery(query, action);
+
+        expect(result.refId).toEqual('A');
+        expect(result.expr).toEqual('go_goroutines{cluster="us-cluster",pod!="pod-123"}');
+      });
+    });
+  });
+});
+
 function createDataRequest(targets: any[], overrides?: Partial<DataQueryRequest>): DataQueryRequest<PromQuery> {
   const defaults = {
     app: CoreApp.Dashboard,
diff --git a/public/app/plugins/datasource/prometheus/datasource.ts b/public/app/plugins/datasource/prometheus/datasource.ts
index 77c6ab39f8a..5ab4aeb85bf 100644
--- a/public/app/plugins/datasource/prometheus/datasource.ts
+++ b/public/app/plugins/datasource/prometheus/datasource.ts
@@ -693,6 +693,10 @@ export class PrometheusDatasource extends DataSourceApi<PromQuery, PromOptions>
         expression = addLabelToQuery(expression, action.key, action.value);
         break;
       }
+      case 'ADD_FILTER_OUT': {
+        expression = addLabelToQuery(expression, action.key, action.value, '!=');
+        break;
+      }
       case 'ADD_HISTOGRAM_QUANTILE': {
         expression = `histogram_quantile(0.95, sum(rate(${expression}[5m])) by (le))`;
         break;
diff --git a/public/app/plugins/panel/table/TablePanel.tsx b/public/app/plugins/panel/table/TablePanel.tsx
index f31a65b698d..49d424470dc 100644
--- a/public/app/plugins/panel/table/TablePanel.tsx
+++ b/public/app/plugins/panel/table/TablePanel.tsx
@@ -1,11 +1,14 @@
 import React, { Component } from 'react';
 
-import { Table, Select } from '@grafana/ui';
-import { FieldMatcherID, PanelProps, DataFrame, SelectableValue, getFrameDisplayName } from '@grafana/data';
+import { Select, Table } from '@grafana/ui';
+import { DataFrame, FieldMatcherID, getFrameDisplayName, PanelProps, SelectableValue } from '@grafana/data';
 import { Options } from './types';
 import { css } from 'emotion';
 import { config } from 'app/core/config';
-import { TableSortByFieldState } from '@grafana/ui/src/components/Table/types';
+import { FilterItem, TableSortByFieldState } from '@grafana/ui/src/components/Table/types';
+import { dispatch } from '../../../store/store';
+import { applyFilterFromTable } from '../../../features/variables/adhoc/actions';
+import { getDashboardSrv } from '../../../features/dashboard/services/DashboardSrv';
 
 interface Props extends PanelProps<Options> {}
 
@@ -62,6 +65,20 @@ export class TablePanel extends Component<Props> {
     this.forceUpdate();
   };
 
+  onCellFilterAdded = (filter: FilterItem) => {
+    const { key, value, operator } = filter;
+    const panelModel = getDashboardSrv()
+      .getCurrent()
+      .getPanelById(this.props.id);
+    const datasource = panelModel?.datasource;
+
+    if (!datasource) {
+      return;
+    }
+
+    dispatch(applyFilterFromTable({ datasource, key, operator, value }));
+  };
+
   renderTable(frame: DataFrame, width: number, height: number) {
     const { options } = this.props;
 
@@ -75,6 +92,7 @@ export class TablePanel extends Component<Props> {
         initialSortBy={options.sortBy}
         onSortByChange={this.onSortByChange}
         onColumnResize={this.onColumnResize}
+        onCellFilterAdded={this.onCellFilterAdded}
       />
     );
   }