diff --git a/public/app/core/services/backend_srv.ts b/public/app/core/services/backend_srv.ts
index 331f0b00ab2..be9a2c01cbf 100644
--- a/public/app/core/services/backend_srv.ts
+++ b/public/app/core/services/backend_srv.ts
@@ -55,11 +55,16 @@ export interface FolderRequestOptions {
 
 const GRAFANA_TRACEID_HEADER = 'grafana-trace-id';
 
+export interface InspectorStream {
+  response: FetchResponse | FetchError;
+  requestId?: string;
+}
+
 export class BackendSrv implements BackendService {
   private inFlightRequests: Subject<string> = new Subject<string>();
   private HTTP_REQUEST_CANCELED = -1;
   private noBackendCache: boolean;
-  private inspectorStream: Subject<FetchResponse | FetchError> = new Subject<FetchResponse | FetchError>();
+  private inspectorStream: Subject<InspectorStream> = new Subject<InspectorStream>();
   private readonly fetchQueue: FetchQueue;
   private readonly responseQueue: ResponseQueue;
   private _tokenRotationInProgress?: Observable<FetchResponse> | null = null;
@@ -333,7 +338,7 @@ export class BackendSrv implements BackendService {
       }, 50);
     }
 
-    this.inspectorStream.next(err);
+    this.inspectorStream.next({ response: err, requestId: options.requestId });
     return err;
   }
 
@@ -356,7 +361,7 @@ export class BackendSrv implements BackendService {
         }),
         tap((response) => {
           this.showSuccessAlert(response);
-          this.inspectorStream.next(response);
+          this.inspectorStream.next({ response: response, requestId: options.requestId });
         })
       );
   }
@@ -446,7 +451,7 @@ export class BackendSrv implements BackendService {
       );
   }
 
-  getInspectorStream(): Observable<FetchResponse | FetchError> {
+  getInspectorStream(): Observable<InspectorStream> {
     return this.inspectorStream;
   }
 
diff --git a/public/app/core/specs/backend_srv.test.ts b/public/app/core/specs/backend_srv.test.ts
index 25dd30124f8..54118ce553f 100644
--- a/public/app/core/specs/backend_srv.test.ts
+++ b/public/app/core/specs/backend_srv.test.ts
@@ -664,7 +664,7 @@ describe('backendSrv', () => {
 
         let inspectorPacket: FetchResponse | FetchError;
         backendSrv.getInspectorStream().subscribe({
-          next: (rsp) => (inspectorPacket = rsp),
+          next: (rsp) => (inspectorPacket = rsp.response),
         });
 
         await backendSrv.datasourceRequest(options).catch((error) => {
diff --git a/public/app/core/utils/explore.ts b/public/app/core/utils/explore.ts
index 49fff84b18b..7852a73a263 100644
--- a/public/app/core/utils/explore.ts
+++ b/public/app/core/utils/explore.ts
@@ -101,6 +101,10 @@ export async function getExploreUrl(args: GetExploreUrlArguments): Promise<strin
   return urlUtil.renderUrl('/explore', { panes: exploreState, schemaVersion: 1 });
 }
 
+export function requestIdGenerator(exploreId: string) {
+  return `explore_${exploreId}`;
+}
+
 export function buildQueryTransaction(
   exploreId: string,
   queries: DataQuery[],
@@ -123,7 +127,7 @@ export function buildQueryTransaction(
     panelId,
     targets: queries, // Datasources rely on DataQueries being passed under the targets key.
     range,
-    requestId: 'explore_' + exploreId,
+    requestId: requestIdGenerator(exploreId),
     rangeRaw: range.raw,
     scopedVars: {
       __interval: { text: interval, value: interval },
diff --git a/public/app/features/explore/Explore.tsx b/public/app/features/explore/Explore.tsx
index 5132e9d1cd9..4d27d12d865 100644
--- a/public/app/features/explore/Explore.tsx
+++ b/public/app/features/explore/Explore.tsx
@@ -682,6 +682,7 @@ export class Explore extends React.PureComponent<Props, ExploreState> {
                                   width={width}
                                   onClose={this.toggleShowQueryInspector}
                                   timeZone={timeZone}
+                                  isMixed={datasourceInstance.meta.mixed || false}
                                 />
                               )}
                             </ErrorBoundaryAlert>
diff --git a/public/app/features/explore/ExploreQueryInspector.test.tsx b/public/app/features/explore/ExploreQueryInspector.test.tsx
index 3210ba6e782..c52d0533a88 100644
--- a/public/app/features/explore/ExploreQueryInspector.test.tsx
+++ b/public/app/features/explore/ExploreQueryInspector.test.tsx
@@ -4,6 +4,7 @@ import AutoSizer from 'react-virtualized-auto-sizer';
 import { Observable } from 'rxjs';
 
 import { LoadingState, InternalTimeZones, getDefaultTimeRange } from '@grafana/data';
+import { InspectorStream } from 'app/core/services/backend_srv';
 
 import { ExploreQueryInspector } from './ExploreQueryInspector';
 
@@ -50,6 +51,7 @@ const setup = (propOverrides = {}) => {
     exploreId: 'left',
     onClose: jest.fn(),
     timeZone: InternalTimeZones.utc,
+    isMixed: false,
     queryResponse: {
       state: LoadingState.Done,
       series: [],
@@ -143,22 +145,26 @@ describe('ExploreQueryInspector', () => {
   });
 });
 
-const response = (hideFromInspector = false) => ({
-  status: 1,
-  statusText: '',
-  ok: true,
-  headers: {},
-  redirected: false,
-  type: 'basic',
-  url: '',
-  request: {},
-  data: {
-    test: {
-      testKey: 'Very unique test value',
+const response = (hideFromInspector = false): InspectorStream => {
+  return {
+    response: {
+      status: 1,
+      statusText: '',
+      ok: true,
+      headers: new Headers(),
+      redirected: false,
+      type: 'basic',
+      url: '',
+      data: {
+        test: {
+          testKey: 'Very unique test value',
+        },
+      },
+      config: {
+        url: '',
+        hideFromInspector,
+      },
     },
-  },
-  config: {
-    url: '',
-    hideFromInspector,
-  },
-});
+    requestId: 'explore_left',
+  };
+};
diff --git a/public/app/features/explore/ExploreQueryInspector.tsx b/public/app/features/explore/ExploreQueryInspector.tsx
index 1d6204c5fce..4b611fae705 100644
--- a/public/app/features/explore/ExploreQueryInspector.tsx
+++ b/public/app/features/explore/ExploreQueryInspector.tsx
@@ -5,12 +5,14 @@ import { CoreApp, LoadingState } from '@grafana/data';
 import { reportInteraction } from '@grafana/runtime/src';
 import { defaultTimeZone, TimeZone } from '@grafana/schema';
 import { TabbedContainer, TabConfig } from '@grafana/ui';
+import { requestIdGenerator } from 'app/core/utils/explore';
 import { ExploreDrawer } from 'app/features/explore/ExploreDrawer';
 import { InspectDataTab } from 'app/features/inspector/InspectDataTab';
 import { InspectErrorTab } from 'app/features/inspector/InspectErrorTab';
 import { InspectJSONTab } from 'app/features/inspector/InspectJSONTab';
 import { InspectStatsTab } from 'app/features/inspector/InspectStatsTab';
 import { QueryInspector } from 'app/features/inspector/QueryInspector';
+import { mixedRequestId } from 'app/plugins/datasource/mixed/MixedDataSource';
 import { StoreState, ExploreItemState } from 'app/types';
 
 import { GetDataOptions } from '../query/state/PanelQueryRunner';
@@ -22,12 +24,13 @@ interface DispatchProps {
   exploreId: string;
   timeZone: TimeZone;
   onClose: () => void;
+  isMixed: boolean;
 }
 
 type Props = DispatchProps & ConnectedProps<typeof connector>;
 
 export function ExploreQueryInspector(props: Props) {
-  const { width, onClose, queryResponse, timeZone } = props;
+  const { width, onClose, queryResponse, timeZone, isMixed, exploreId } = props;
   const [dataOptions, setDataOptions] = useState<GetDataOptions>({
     withTransforms: false,
     withFieldConfig: true,
@@ -79,7 +82,11 @@ export function ExploreQueryInspector(props: Props) {
     value: 'query',
     icon: 'info-circle',
     content: (
-      <QueryInspector data={queryResponse} onRefreshQuery={() => props.runQueries({ exploreId: props.exploreId })} />
+      <QueryInspector
+        instanceId={isMixed ? mixedRequestId(0, requestIdGenerator(exploreId)) : requestIdGenerator(exploreId)}
+        data={queryResponse}
+        onRefreshQuery={() => props.runQueries({ exploreId })}
+      />
     ),
   };
 
diff --git a/public/app/features/inspector/QueryInspector.tsx b/public/app/features/inspector/QueryInspector.tsx
index 23e1fac5290..fb1e0cd8238 100644
--- a/public/app/features/inspector/QueryInspector.tsx
+++ b/public/app/features/inspector/QueryInspector.tsx
@@ -19,6 +19,7 @@ interface ExecutedQueryInfo {
 }
 
 interface Props {
+  instanceId?: string; // Must match the prefix of the requestId of the query being inspected. For updating only one instance of the inspector in case of multiple instances, ie Explore split view
   data: PanelData;
   onRefreshQuery: () => void;
 }
@@ -49,7 +50,15 @@ export class QueryInspector extends PureComponent<Props, State> {
   componentDidMount() {
     this.subs.add(
       backendSrv.getInspectorStream().subscribe({
-        next: (response) => this.onDataSourceResponse(response),
+        next: (response) => {
+          let update = true;
+          if (this.props.instanceId && response?.requestId) {
+            update = response.requestId.startsWith(this.props.instanceId);
+          }
+          if (update) {
+            return this.onDataSourceResponse(response.response);
+          }
+        },
       })
     );
   }
diff --git a/public/app/plugins/datasource/mixed/MixedDataSource.ts b/public/app/plugins/datasource/mixed/MixedDataSource.ts
index d0296261f99..2466cdcbda9 100644
--- a/public/app/plugins/datasource/mixed/MixedDataSource.ts
+++ b/public/app/plugins/datasource/mixed/MixedDataSource.ts
@@ -15,6 +15,8 @@ import { getDataSourceSrv, toDataQueryError } from '@grafana/runtime';
 
 export const MIXED_DATASOURCE_NAME = '-- Mixed --';
 
+export const mixedRequestId = (queryIdx: number, requestId?: string) => `mixed-${queryIdx}-${requestId || ''}`;
+
 export interface BatchedQueries {
   datasource: Promise<DataSourceApi>;
   targets: DataQuery[];
@@ -61,7 +63,7 @@ export class MixedDatasource extends DataSourceApi<DataQuery> {
       from(query.datasource).pipe(
         mergeMap((api: DataSourceApi) => {
           const dsRequest = cloneDeep(request);
-          dsRequest.requestId = `mixed-${i}-${dsRequest.requestId || ''}`;
+          dsRequest.requestId = mixedRequestId(i, dsRequest.requestId);
           dsRequest.targets = query.targets;
 
           return from(api.query(dsRequest)).pipe(
@@ -70,7 +72,7 @@ export class MixedDatasource extends DataSourceApi<DataQuery> {
                 ...response,
                 data: response.data || [],
                 state: LoadingState.Loading,
-                key: `mixed-${i}-${response.key || ''}`,
+                key: mixedRequestId(i, response.key),
               };
             }),
             toArray(),
@@ -83,7 +85,7 @@ export class MixedDatasource extends DataSourceApi<DataQuery> {
                   data: [],
                   state: LoadingState.Error,
                   error: err,
-                  key: `mixed-${i}-${dsRequest.requestId || ''}`,
+                  key: mixedRequestId(i, dsRequest.requestId),
                 },
               ]);
             })