diff --git a/packages/grafana-data/src/datetime/moment_wrapper.ts b/packages/grafana-data/src/datetime/moment_wrapper.ts
index 0b97de1a3bf..6b60bb524bd 100644
--- a/packages/grafana-data/src/datetime/moment_wrapper.ts
+++ b/packages/grafana-data/src/datetime/moment_wrapper.ts
@@ -53,7 +53,7 @@ export interface DateTimeDuration {
 
 export interface DateTime extends Object {
   add: (amount?: DateTimeInput, unit?: DurationUnit) => DateTime;
-  set: (unit: DurationUnit, amount: DateTimeInput) => void;
+  set: (unit: DurationUnit | 'date', amount: DateTimeInput) => void;
   diff: (amount: DateTimeInput, unit?: DurationUnit, truncate?: boolean) => number;
   endOf: (unitOfTime: DurationUnit) => DateTime;
   format: (formatInput?: FormatInput) => string;
diff --git a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.test.tsx b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.test.tsx
index 1f4bed87550..5258ee22ad0 100644
--- a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.test.tsx
+++ b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.test.tsx
@@ -2,15 +2,23 @@ import { render, screen } from '@testing-library/react';
 import userEvent from '@testing-library/user-event';
 import React from 'react';
 
-import { dateTime } from '@grafana/data';
+import { dateTime, dateTimeAsMoment, dateTimeForTimeZone, getTimeZone, setTimeZoneResolver } from '@grafana/data';
 import { Components } from '@grafana/e2e-selectors';
 
 import { DateTimePicker, Props } from './DateTimePicker';
 
+// An assortment of timezones that we will test the behavior of the DateTimePicker with different timezones
+const TEST_TIMEZONES = ['browser', 'Europe/Stockholm', 'America/Indiana/Marengo'];
+
+const defaultTimeZone = getTimeZone();
+afterAll(() => {
+  return setTimeZoneResolver(() => defaultTimeZone);
+});
+
 const renderDatetimePicker = (props?: Props) => {
   const combinedProps = Object.assign(
     {
-      date: dateTime('2021-05-05 12:00:00'),
+      date: dateTimeForTimeZone(getTimeZone(), '2021-05-05 12:00:00'),
       onChange: () => {},
     },
     props
@@ -26,12 +34,22 @@ describe('Date time picker', () => {
     expect(screen.queryByTestId('date-time-picker')).toBeInTheDocument();
   });
 
-  it('input should have a value', () => {
+  it.each(TEST_TIMEZONES)('input should have a value (timezone: %s)', (timeZone) => {
+    setTimeZoneResolver(() => timeZone);
     renderDatetimePicker();
-    expect(screen.queryByDisplayValue('2021-05-05 12:00:00')).toBeInTheDocument();
+    const dateTimeInput = screen.getByTestId(Components.DateTimePicker.input);
+    expect(dateTimeInput).toHaveDisplayValue('2021-05-05 12:00:00');
   });
 
-  it('should update date onblur', async () => {
+  it.each(TEST_TIMEZONES)('should render (timezone %s)', (timeZone) => {
+    setTimeZoneResolver(() => timeZone);
+    renderDatetimePicker();
+    const dateTimeInput = screen.getByTestId(Components.DateTimePicker.input);
+    expect(dateTimeInput).toHaveDisplayValue('2021-05-05 12:00:00');
+  });
+
+  it.each(TEST_TIMEZONES)('should update date onblur (timezone: %)', async (timeZone) => {
+    setTimeZoneResolver(() => timeZone);
     const onChangeInput = jest.fn();
     render(<DateTimePicker date={dateTime('2021-05-05 12:00:00')} onChange={onChangeInput} />);
     const dateTimeInput = screen.getByTestId(Components.DateTimePicker.input);
@@ -42,7 +60,8 @@ describe('Date time picker', () => {
     expect(onChangeInput).toHaveBeenCalled();
   });
 
-  it('should not update onblur if invalid date', async () => {
+  it.each(TEST_TIMEZONES)('should not update onblur if invalid date (timezone: %s)', async (timeZone) => {
+    setTimeZoneResolver(() => timeZone);
     const onChangeInput = jest.fn();
     render(<DateTimePicker date={dateTime('2021-05-05 12:00:00')} onChange={onChangeInput} />);
     const dateTimeInput = screen.getByTestId(Components.DateTimePicker.input);
@@ -53,31 +72,167 @@ describe('Date time picker', () => {
     expect(onChangeInput).not.toHaveBeenCalled();
   });
 
-  it('should be able to select values in TimeOfDayPicker without blurring the element', async () => {
-    renderDatetimePicker();
+  it.each(TEST_TIMEZONES)(
+    'should not change the day at times near the day boundary (timezone: %s)',
+    async (timeZone) => {
+      setTimeZoneResolver(() => timeZone);
+      const onChangeInput = jest.fn();
+      render(<DateTimePicker date={dateTime('2021-05-05 12:34:56')} onChange={onChangeInput} />);
 
-    // open the calendar + time picker
-    await userEvent.click(screen.getByLabelText('Time picker'));
+      // Click the calendar button
+      await userEvent.click(screen.getByRole('button', { name: 'Time picker' }));
 
-    // open the time of day overlay
-    await userEvent.click(screen.getAllByRole('textbox')[1]);
+      // Check the active day is the 5th
+      expect(screen.getByRole('button', { name: 'May 5, 2021' })).toHaveClass('react-calendar__tile--active');
 
-    // check the hour element is visible
-    const hourElement = screen.getAllByRole('button', {
-      name: '00',
-    })[0];
-    expect(hourElement).toBeVisible();
+      // open the time of day overlay
+      await userEvent.click(screen.getAllByRole('textbox')[1]);
 
-    // select the hour value and check it's still visible
-    await userEvent.click(hourElement);
-    expect(hourElement).toBeVisible();
+      // change the hour
+      await userEvent.click(
+        screen.getAllByRole('button', {
+          name: '00',
+        })[0]
+      );
 
-    // click outside the overlay and check the hour element is no longer visible
+      // Check the active day is the 5th
+      expect(screen.getByRole('button', { name: 'May 5, 2021' })).toHaveClass('react-calendar__tile--active');
+
+      // change the hour
+      await userEvent.click(
+        screen.getAllByRole('button', {
+          name: '23',
+        })[0]
+      );
+
+      // Check the active day is the 5th
+      expect(screen.getByRole('button', { name: 'May 5, 2021' })).toHaveClass('react-calendar__tile--active');
+    }
+  );
+
+  it.each(TEST_TIMEZONES)(
+    'should not reset the time when selecting a different day (timezone: %s)',
+    async (timeZone) => {
+      setTimeZoneResolver(() => timeZone);
+      const onChangeInput = jest.fn();
+      render(<DateTimePicker date={dateTime('2021-05-05 12:34:56')} onChange={onChangeInput} />);
+
+      // Click the calendar button
+      await userEvent.click(screen.getByRole('button', { name: 'Time picker' }));
+
+      // Select a different day in the calendar
+      await userEvent.click(screen.getByRole('button', { name: 'May 15, 2021' }));
+
+      const timeInput = screen.getAllByRole('textbox')[1];
+      expect(timeInput).toHaveClass('rc-time-picker-input');
+      expect(timeInput).not.toHaveDisplayValue('00:00:00');
+    }
+  );
+
+  it.each(TEST_TIMEZONES)(
+    'should always show the correct matching day in the calendar (timezone: %s)',
+    async (timeZone) => {
+      setTimeZoneResolver(() => timeZone);
+      const onChangeInput = jest.fn();
+      render(<DateTimePicker date={dateTime('2021-05-05T23:59:41.000000Z')} onChange={onChangeInput} />);
+
+      const dateTimeInputValue = screen.getByTestId(Components.DateTimePicker.input).getAttribute('value')!;
+
+      // takes the string from the input
+      // depending on the timezone, this will look something like 2024-04-05 19:59:41
+      // parses out the day value and strips the leading 0
+      const day = parseInt(dateTimeInputValue.split(' ')[0].split('-')[2], 10);
+
+      // Click the calendar button
+      await userEvent.click(screen.getByRole('button', { name: 'Time picker' }));
+
+      // Check the active day matches the input
+      expect(screen.getByRole('button', { name: `May ${day}, 2021` })).toHaveClass('react-calendar__tile--active');
+    }
+  );
+
+  it.each(TEST_TIMEZONES)(
+    'should always show the correct matching day when selecting a date in the calendar (timezone: %s)',
+    async (timeZone) => {
+      setTimeZoneResolver(() => timeZone);
+      const onChangeInput = jest.fn();
+      render(<DateTimePicker date={dateTime('2021-05-05T23:59:41.000000Z')} onChange={onChangeInput} />);
+
+      // Click the calendar button
+      await userEvent.click(screen.getByRole('button', { name: 'Time picker' }));
+
+      // Select a new day
+      const day = 8;
+      await userEvent.click(screen.getByRole('button', { name: `May ${day}, 2021` }));
+      await userEvent.click(screen.getByRole('button', { name: 'Apply' }));
+
+      const onChangeInputArg = onChangeInput.mock.calls[0][0];
+
+      expect(dateTimeAsMoment(dateTimeForTimeZone(timeZone, onChangeInputArg)).date()).toBe(day);
+    }
+  );
+
+  it.each(TEST_TIMEZONES)('should not alter a UTC time when blurring (timezone: %s)', async (timeZone) => {
+    setTimeZoneResolver(() => timeZone);
+    const onChangeInput = jest.fn();
+
+    // render with a UTC value
+    const { rerender } = render(
+      <DateTimePicker date={dateTime('2024-04-16T08:44:41.000000Z')} onChange={onChangeInput} />
+    );
+
+    const inputValue = screen.getByTestId(Components.DateTimePicker.input).getAttribute('value')!;
+
+    // blur the input to trigger an onChange
+    await userEvent.click(screen.getByTestId(Components.DateTimePicker.input));
     await userEvent.click(document.body);
-    expect(
-      screen.queryByRole('button', {
-        name: '00',
-      })
-    ).not.toBeInTheDocument();
+
+    const onChangeValue = onChangeInput.mock.calls[0][0];
+    expect(onChangeInput).toHaveBeenCalledWith(onChangeValue);
+
+    // now rerender with the "changed" value
+    rerender(<DateTimePicker date={onChangeValue} onChange={onChangeInput} />);
+
+    // expect the input to show the same value
+    expect(screen.getByTestId(Components.DateTimePicker.input)).toHaveDisplayValue(inputValue);
+
+    // blur the input to trigger an onChange
+    await userEvent.click(screen.getByTestId(Components.DateTimePicker.input));
+    await userEvent.click(document.body);
+
+    // expect the onChange to be called with the same value
+    expect(onChangeInput).toHaveBeenCalledWith(onChangeValue);
   });
+
+  it.each(TEST_TIMEZONES)(
+    'should be able to select values in TimeOfDayPicker without blurring the element (timezone: %s)',
+    async (timeZone) => {
+      setTimeZoneResolver(() => timeZone);
+      renderDatetimePicker();
+
+      // open the calendar + time picker
+      await userEvent.click(screen.getByLabelText('Time picker'));
+
+      // open the time of day overlay
+      await userEvent.click(screen.getAllByRole('textbox')[1]);
+
+      // check the hour element is visible
+      const hourElement = screen.getAllByRole('button', {
+        name: '00',
+      })[0];
+      expect(hourElement).toBeVisible();
+
+      // select the hour value and check it's still visible
+      await userEvent.click(hourElement);
+      expect(hourElement).toBeVisible();
+
+      // click outside the overlay and check the hour element is no longer visible
+      await userEvent.click(document.body);
+      expect(
+        screen.queryByRole('button', {
+          name: '00',
+        })
+      ).not.toBeInTheDocument();
+    }
+  );
 });
diff --git a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.tsx b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.tsx
index 3df2c3b7565..60d8ba4bdb2 100644
--- a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.tsx
+++ b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.tsx
@@ -7,7 +7,15 @@ import React, { FormEvent, ReactNode, useCallback, useEffect, useRef, useState }
 import Calendar from 'react-calendar';
 import { useMedia } from 'react-use';
 
-import { dateTimeFormat, DateTime, dateTime, GrafanaTheme2, isDateTime } from '@grafana/data';
+import {
+  dateTimeFormat,
+  DateTime,
+  dateTime,
+  GrafanaTheme2,
+  isDateTime,
+  dateTimeForTimeZone,
+  getTimeZone,
+} from '@grafana/data';
 import { Components } from '@grafana/e2e-selectors';
 
 import { useStyles2, useTheme2 } from '../../../themes';
@@ -21,6 +29,7 @@ import { Portal } from '../../Portal/Portal';
 import { TimeOfDayPicker, POPUP_CLASS_NAME } from '../TimeOfDayPicker';
 import { getBodyStyles } from '../TimeRangePicker/CalendarBody';
 import { isValid } from '../utils';
+import { adjustDateForReactCalendar } from '../utils/adjustDateForReactCalendar';
 
 export interface Props {
   /** Input date for the component */
@@ -227,7 +236,7 @@ const DateTimeInput = React.forwardRef<HTMLInputElement, InputProps>(
 
     const onBlur = useCallback(() => {
       if (!internalDate.invalid) {
-        const date = dateTime(internalDate.value);
+        const date = dateTimeForTimeZone(getTimeZone(), internalDate.value);
         onChange(date);
       }
     }, [internalDate, onChange]);
@@ -276,9 +285,18 @@ const DateTimeCalendar = React.forwardRef<HTMLDivElement, DateTimeCalendarProps>
   ) => {
     const calendarStyles = useStyles2(getBodyStyles);
     const styles = useStyles2(getStyles);
-    const [internalDate, setInternalDate] = useState<Date>(() => {
+
+    // need to keep these 2 separate in state since react-calendar doesn't support different timezones
+    const [timeOfDayDateTime, setTimeOfDayDateTime] = useState(() => {
       if (date && date.isValid()) {
-        return date.toDate();
+        return dateTimeForTimeZone(getTimeZone(), date);
+      }
+
+      return dateTimeForTimeZone(getTimeZone(), new Date());
+    });
+    const [reactCalendarDate, setReactCalendarDate] = useState<Date>(() => {
+      if (date && date.isValid()) {
+        return adjustDateForReactCalendar(date.toDate(), getTimeZone());
       }
 
       return new Date();
@@ -286,28 +304,33 @@ const DateTimeCalendar = React.forwardRef<HTMLDivElement, DateTimeCalendarProps>
 
     const onChangeDate = useCallback<NonNullable<React.ComponentProps<typeof Calendar>['onChange']>>((date) => {
       if (date && !Array.isArray(date)) {
-        setInternalDate((prevState) => {
-          // If we don't use time from prevState
-          // the time will be reset to 00:00:00
-          date.setHours(prevState.getHours());
-          date.setMinutes(prevState.getMinutes());
-          date.setSeconds(prevState.getSeconds());
-
-          return date;
-        });
+        setReactCalendarDate(date);
       }
     }, []);
 
     const onChangeTime = useCallback((date: DateTime) => {
-      setInternalDate(date.toDate());
+      setTimeOfDayDateTime(date);
     }, []);
 
+    // here we need to stitch the 2 date objects back together
+    const handleApply = () => {
+      // we take the date that's set by TimeOfDayPicker
+      const newDate = dateTime(timeOfDayDateTime);
+
+      // and apply the date/month/year set by react-calendar
+      newDate.set('date', reactCalendarDate.getDate());
+      newDate.set('month', reactCalendarDate.getMonth());
+      newDate.set('year', reactCalendarDate.getFullYear());
+
+      onChange(newDate);
+    };
+
     return (
       <div className={cx(styles.container, { [styles.fullScreen]: isFullscreen })} style={style} ref={ref}>
         <Calendar
           next2Label={null}
           prev2Label={null}
-          value={internalDate}
+          value={reactCalendarDate}
           nextLabel={<Icon name="angle-right" />}
           nextAriaLabel="Next month"
           prevLabel={<Icon name="angle-left" />}
@@ -323,14 +346,14 @@ const DateTimeCalendar = React.forwardRef<HTMLDivElement, DateTimeCalendarProps>
           <TimeOfDayPicker
             showSeconds={showSeconds}
             onChange={onChangeTime}
-            value={dateTime(internalDate)}
+            value={timeOfDayDateTime}
             disabledHours={disabledHours}
             disabledMinutes={disabledMinutes}
             disabledSeconds={disabledSeconds}
           />
         </div>
         <Stack>
-          <Button type="button" onClick={() => onChange(dateTime(internalDate))}>
+          <Button type="button" onClick={handleApply}>
             Apply
           </Button>
           <Button variant="secondary" type="button" onClick={onClose}>
diff --git a/packages/grafana-ui/src/components/DateTimePickers/TimeRangePicker/CalendarBody.tsx b/packages/grafana-ui/src/components/DateTimePickers/TimeRangePicker/CalendarBody.tsx
index f115d536d85..8e13c04a5b9 100644
--- a/packages/grafana-ui/src/components/DateTimePickers/TimeRangePicker/CalendarBody.tsx
+++ b/packages/grafana-ui/src/components/DateTimePickers/TimeRangePicker/CalendarBody.tsx
@@ -2,10 +2,11 @@ import { css } from '@emotion/css';
 import React, { useCallback } from 'react';
 import Calendar from 'react-calendar';
 
-import { GrafanaTheme2, dateTimeParse, DateTime, TimeZone, getZone } from '@grafana/data';
+import { GrafanaTheme2, dateTimeParse, DateTime, TimeZone } from '@grafana/data';
 
 import { useStyles2 } from '../../../themes';
 import { Icon } from '../../Icon/Icon';
+import { adjustDateForReactCalendar } from '../utils/adjustDateForReactCalendar';
 
 import { TimePickerCalendarProps } from './TimePickerCalendar';
 
@@ -42,7 +43,8 @@ export function inputToValue(
   let toAsDate = to.isValid() ? to.toDate() : invalidDateDefault;
 
   if (timezone) {
-    [fromAsDate, toAsDate] = adjustDateForReactCalendar(fromAsDate, toAsDate, timezone);
+    fromAsDate = adjustDateForReactCalendar(fromAsDate, timezone);
+    toAsDate = adjustDateForReactCalendar(toAsDate, timezone);
   }
 
   if (fromAsDate > toAsDate) {
@@ -52,39 +54,6 @@ export function inputToValue(
   return [fromAsDate, toAsDate];
 }
 
-/**
- * React calendar doesn't support showing ranges in other time zones, so attempting to show
- * 10th midnight - 11th midnight in another time zone than your browsers will span three days
- * instead of two.
- *
- * This function adjusts the dates by "moving" the time to appear as if it's local.
- * e.g. make 5 PM New York "look like" 5 PM in the user's local browser time.
- * See also https://github.com/wojtekmaj/react-calendar/issues/511#issuecomment-835333976
- */
-function adjustDateForReactCalendar(from: Date, to: Date, timeZone: string): [Date, Date] {
-  const zone = getZone(timeZone);
-  if (!zone) {
-    return [from, to];
-  }
-
-  // get utc offset for timezone preference
-  const timezonePrefFromOffset = zone.utcOffset(from.getTime());
-  const timezonePrefToOffset = zone.utcOffset(to.getTime());
-
-  // get utc offset for local timezone
-  const localFromOffset = from.getTimezoneOffset();
-  const localToOffset = to.getTimezoneOffset();
-
-  // calculate difference between timezone preference and local timezone
-  // we keep these as separate variables in case one of them crosses a daylight savings boundary
-  const fromDiff = timezonePrefFromOffset - localFromOffset;
-  const toDiff = timezonePrefToOffset - localToOffset;
-
-  const newFromDate = new Date(from.getTime() - fromDiff * 1000 * 60);
-  const newToDate = new Date(to.getTime() - toDiff * 1000 * 60);
-  return [newFromDate, newToDate];
-}
-
 function useOnCalendarChange(onChange: (from: DateTime, to: DateTime) => void, timeZone?: TimeZone) {
   return useCallback<NonNullable<React.ComponentProps<typeof Calendar>['onChange']>>(
     (value) => {
diff --git a/packages/grafana-ui/src/components/DateTimePickers/utils/adjustDateForReactCalendar.ts b/packages/grafana-ui/src/components/DateTimePickers/utils/adjustDateForReactCalendar.ts
new file mode 100644
index 00000000000..b8f0f2e5f3c
--- /dev/null
+++ b/packages/grafana-ui/src/components/DateTimePickers/utils/adjustDateForReactCalendar.ts
@@ -0,0 +1,28 @@
+import { getZone } from '@grafana/data';
+
+/**
+ * React calendar doesn't support showing dates in other time zones, so attempting to show
+ * values near midnight in another time zone than your browsers may end up showing the wrong date
+ *
+ * This function adjusts a date by "moving" the time to appear as if it's local.
+ * e.g. make 5 PM New York "look like" 5 PM in the user's local browser time.
+ * See also https://github.com/wojtekmaj/react-calendar/issues/511#issuecomment-835333976
+ */
+export function adjustDateForReactCalendar(date: Date, timeZone: string): Date {
+  const zone = getZone(timeZone);
+  if (!zone) {
+    return date;
+  }
+
+  // get utc offset for timezone preference
+  const timezonePrefOffset = zone.utcOffset(date.getTime());
+
+  // get utc offset for local timezone
+  const localOffset = date.getTimezoneOffset();
+
+  // calculate difference between timezone preference and local timezone
+  const diff = timezonePrefOffset - localOffset;
+
+  const newDate = new Date(date.getTime() - diff * 1000 * 60);
+  return newDate;
+}