diff --git a/packages/grafana-runtime/src/index.ts b/packages/grafana-runtime/src/index.ts
index d7e297a97e0..f653bec807a 100644
--- a/packages/grafana-runtime/src/index.ts
+++ b/packages/grafana-runtime/src/index.ts
@@ -12,6 +12,7 @@ export { featureEnabled } from './utils/licensing';
 export { logInfo, logDebug, logWarning, logError } from './utils/logging';
 export {
   DataSourceWithBackend,
+  HealthCheckError,
   HealthCheckResult,
   HealthCheckResultDetails,
   HealthStatus,
diff --git a/packages/grafana-runtime/src/services/backendSrv.ts b/packages/grafana-runtime/src/services/backendSrv.ts
index 4260ef410de..b5bdd774a2f 100644
--- a/packages/grafana-runtime/src/services/backendSrv.ts
+++ b/packages/grafana-runtime/src/services/backendSrv.ts
@@ -123,6 +123,10 @@ export interface FetchError<T = any> {
   config: BackendSrvRequest;
 }
 
+export function isFetchError(e: unknown): e is FetchError {
+  return typeof e === 'object' && e !== null && 'status' in e && 'data' in e;
+}
+
 /**
  * Used to communicate via http(s) to a remote backend such as the Grafana backend,
  * a datasource etc. The BackendSrv is using the {@link https://developer.mozilla.org/en-US/docs/Web/API/Fetch_API | Fetch API}
diff --git a/packages/grafana-runtime/src/utils/DataSourceWithBackend.ts b/packages/grafana-runtime/src/utils/DataSourceWithBackend.ts
index 5bbc93b4a84..81db268ade3 100644
--- a/packages/grafana-runtime/src/utils/DataSourceWithBackend.ts
+++ b/packages/grafana-runtime/src/utils/DataSourceWithBackend.ts
@@ -48,7 +48,7 @@ export function isExpressionReference(ref?: DataSourceRef | string | null): bool
   return v === ExpressionDatasourceRef.type || v === '-100'; // -100 was a legacy accident that should be removed
 }
 
-class HealthCheckError extends Error {
+export class HealthCheckError extends Error {
   details: HealthCheckResultDetails;
 
   constructor(message: string, details: HealthCheckResultDetails) {
diff --git a/public/app/core/components/RolePicker/api.ts b/public/app/core/components/RolePicker/api.ts
index 9f07f61a724..82549055a0c 100644
--- a/public/app/core/components/RolePicker/api.ts
+++ b/public/app/core/components/RolePicker/api.ts
@@ -1,4 +1,4 @@
-import { getBackendSrv } from '@grafana/runtime';
+import { getBackendSrv, isFetchError } from '@grafana/runtime';
 import { Role } from 'app/types';
 
 export const fetchRoleOptions = async (orgId?: number, query?: string): Promise<Role[]> => {
@@ -33,7 +33,9 @@ export const fetchUserRoles = async (userId: number, orgId?: number): Promise<Ro
     }
     return roles;
   } catch (error) {
-    error.isHandled = true;
+    if (isFetchError(error)) {
+      error.isHandled = true;
+    }
     return [];
   }
 };
@@ -62,7 +64,9 @@ export const fetchTeamRoles = async (teamId: number, orgId?: number): Promise<Ro
     }
     return roles;
   } catch (error) {
-    error.isHandled = true;
+    if (isFetchError(error)) {
+      error.isHandled = true;
+    }
     return [];
   }
 };
diff --git a/public/app/core/history/RichHistoryLocalStorage.ts b/public/app/core/history/RichHistoryLocalStorage.ts
index a73cf32e5f6..2a28f5cec14 100644
--- a/public/app/core/history/RichHistoryLocalStorage.ts
+++ b/public/app/core/history/RichHistoryLocalStorage.ts
@@ -78,7 +78,7 @@ export default class RichHistoryLocalStorage implements RichHistoryStorage {
     try {
       store.setObject(RICH_HISTORY_KEY, updatedHistory);
     } catch (error) {
-      if (error.name === 'QuotaExceededError') {
+      if (error instanceof Error && error.name === 'QuotaExceededError') {
         throwError(RichHistoryServiceError.StorageFull, `Saving rich history failed: ${error.message}`);
       } else {
         throw error;
diff --git a/public/app/core/store.ts b/public/app/core/store.ts
index bcbb338dc23..66891035406 100644
--- a/public/app/core/store.ts
+++ b/public/app/core/store.ts
@@ -44,7 +44,9 @@ export class Store {
     } catch (error) {
       // Likely hitting storage quota
       const errorToThrow = new Error(`Could not save item in localStorage: ${key}. [${error}]`);
-      errorToThrow.name = error.name;
+      if (error instanceof Error) {
+        errorToThrow.name = error.name;
+      }
       throw errorToThrow;
     }
     return true;
diff --git a/public/app/core/utils/CancelablePromise.ts b/public/app/core/utils/CancelablePromise.ts
index 027f5678a90..221e5ef2bb6 100644
--- a/public/app/core/utils/CancelablePromise.ts
+++ b/public/app/core/utils/CancelablePromise.ts
@@ -5,12 +5,21 @@ export interface CancelablePromise<T> {
   cancel: () => void;
 }
 
+export interface CancelablePromiseRejection {
+  isCanceled: boolean;
+}
+
+export function isCancelablePromiseRejection(promise: unknown): promise is CancelablePromiseRejection {
+  return typeof promise === 'object' && promise !== null && 'isCanceled' in promise;
+}
+
 export const makePromiseCancelable = <T>(promise: Promise<T>): CancelablePromise<T> => {
   let hasCanceled_ = false;
 
   const wrappedPromise = new Promise<T>((resolve, reject) => {
-    promise.then((val) => (hasCanceled_ ? reject({ isCanceled: true }) : resolve(val)));
-    promise.catch((error) => (hasCanceled_ ? reject({ isCanceled: true }) : reject(error)));
+    const canceledPromiseRejection: CancelablePromiseRejection = { isCanceled: true };
+    promise.then((val) => (hasCanceled_ ? reject(canceledPromiseRejection) : resolve(val)));
+    promise.catch((error) => (hasCanceled_ ? reject(canceledPromiseRejection) : reject(error)));
   });
 
   return {
diff --git a/public/app/core/utils/richHistory.ts b/public/app/core/utils/richHistory.ts
index 560aa4a95a5..c2c34ef50e3 100644
--- a/public/app/core/utils/richHistory.ts
+++ b/public/app/core/utils/richHistory.ts
@@ -58,11 +58,13 @@ export async function addToRichHistory(
       });
       warning = result.warning;
     } catch (error) {
-      if (error.name === RichHistoryServiceError.StorageFull) {
-        richHistoryStorageFull = true;
-        showQuotaExceededError && dispatch(notifyApp(createErrorNotification(error.message)));
-      } else if (error.name !== RichHistoryServiceError.DuplicatedEntry) {
-        dispatch(notifyApp(createErrorNotification('Rich History update failed', error.message)));
+      if (error instanceof Error) {
+        if (error.name === RichHistoryServiceError.StorageFull) {
+          richHistoryStorageFull = true;
+          showQuotaExceededError && dispatch(notifyApp(createErrorNotification(error.message)));
+        } else if (error.name !== RichHistoryServiceError.DuplicatedEntry) {
+          dispatch(notifyApp(createErrorNotification('Rich History update failed', error.message)));
+        }
       }
       // Saving failed. Do not add new entry.
       return { richHistoryStorageFull, limitExceeded };
@@ -101,7 +103,9 @@ export async function updateStarredInRichHistory(id: string, starred: boolean) {
   try {
     return await getRichHistoryStorage().updateStarred(id, starred);
   } catch (error) {
-    dispatch(notifyApp(createErrorNotification('Saving rich history failed', error.message)));
+    if (error instanceof Error) {
+      dispatch(notifyApp(createErrorNotification('Saving rich history failed', error.message)));
+    }
     return undefined;
   }
 }
@@ -110,7 +114,9 @@ export async function updateCommentInRichHistory(id: string, newComment: string
   try {
     return await getRichHistoryStorage().updateComment(id, newComment);
   } catch (error) {
-    dispatch(notifyApp(createErrorNotification('Saving rich history failed', error.message)));
+    if (error instanceof Error) {
+      dispatch(notifyApp(createErrorNotification('Saving rich history failed', error.message)));
+    }
     return undefined;
   }
 }
@@ -120,7 +126,9 @@ export async function deleteQueryInRichHistory(id: string) {
     await getRichHistoryStorage().deleteRichHistory(id);
     return id;
   } catch (error) {
-    dispatch(notifyApp(createErrorNotification('Saving rich history failed', error.message)));
+    if (error instanceof Error) {
+      dispatch(notifyApp(createErrorNotification('Saving rich history failed', error.message)));
+    }
     return undefined;
   }
 }
@@ -156,8 +164,9 @@ export async function migrateQueryHistoryFromLocalStorage(): Promise<LocalStorag
     dispatch(notifyApp(createSuccessNotification('Query history successfully migrated from local storage')));
     return { status: LocalStorageMigrationStatus.Successful };
   } catch (error) {
-    dispatch(notifyApp(createWarningNotification(`Query history migration failed. ${error.message}`)));
-    return { status: LocalStorageMigrationStatus.Failed, error };
+    const errorToThrow = error instanceof Error ? error : new Error('Uknown error occurred.');
+    dispatch(notifyApp(createWarningNotification(`Query history migration failed. ${errorToThrow.message}`)));
+    return { status: LocalStorageMigrationStatus.Failed, error: errorToThrow };
   }
 }
 
diff --git a/public/app/features/admin/state/actions.ts b/public/app/features/admin/state/actions.ts
index d21672fce71..a51a0264836 100644
--- a/public/app/features/admin/state/actions.ts
+++ b/public/app/features/admin/state/actions.ts
@@ -1,7 +1,7 @@
 import { debounce } from 'lodash';
 
 import { dateTimeFormatTimeAgo } from '@grafana/data';
-import { featureEnabled, getBackendSrv, locationService } from '@grafana/runtime';
+import { featureEnabled, getBackendSrv, isFetchError, locationService } from '@grafana/runtime';
 import config from 'app/core/config';
 import { contextSrv } from 'app/core/core';
 import { accessControlQueryParam } from 'app/core/utils/accessControl';
@@ -43,12 +43,14 @@ export function loadAdminUserPage(userId: number): ThunkResult<void> {
     } catch (error) {
       console.error(error);
 
-      const userError = {
-        title: error.data.message,
-        body: error.data.error,
-      };
+      if (isFetchError(error)) {
+        const userError = {
+          title: error.data.message,
+          body: error.data.error,
+        };
 
-      dispatch(userAdminPageFailedAction(userError));
+        dispatch(userAdminPageFailedAction(userError));
+      }
     }
   };
 }
@@ -212,12 +214,14 @@ export function loadLdapState(): ThunkResult<void> {
       const connectionInfo = await getBackendSrv().get(`/api/admin/ldap/status`);
       dispatch(ldapConnectionInfoLoadedAction(connectionInfo));
     } catch (error) {
-      error.isHandled = true;
-      const ldapError = {
-        title: error.data.message,
-        body: error.data.error,
-      };
-      dispatch(ldapFailedAction(ldapError));
+      if (isFetchError(error)) {
+        error.isHandled = true;
+        const ldapError = {
+          title: error.data.message,
+          body: error.data.error,
+        };
+        dispatch(ldapFailedAction(ldapError));
+      }
     }
   };
 }
@@ -235,13 +239,15 @@ export function loadUserMapping(username: string): ThunkResult<void> {
       };
       dispatch(userMappingInfoLoadedAction(userInfo));
     } catch (error) {
-      error.isHandled = true;
-      const userError = {
-        title: error.data.message,
-        body: error.data.error,
-      };
-      dispatch(clearUserMappingInfoAction());
-      dispatch(userMappingInfoFailedAction(userError));
+      if (isFetchError(error)) {
+        error.isHandled = true;
+        const userError = {
+          title: error.data.message,
+          body: error.data.error,
+        };
+        dispatch(clearUserMappingInfoAction());
+        dispatch(userMappingInfoFailedAction(userError));
+      }
     }
   };
 }
diff --git a/public/app/features/alerting/state/actions.ts b/public/app/features/alerting/state/actions.ts
index 11634d3620a..84f5ac3c86e 100644
--- a/public/app/features/alerting/state/actions.ts
+++ b/public/app/features/alerting/state/actions.ts
@@ -1,4 +1,4 @@
-import { getBackendSrv, locationService } from '@grafana/runtime';
+import { getBackendSrv, isFetchError, locationService } from '@grafana/runtime';
 import { notifyApp } from 'app/core/actions';
 import { createErrorNotification, createSuccessNotification } from 'app/core/copy/appNotification';
 import { AlertRuleDTO, NotifierDTO, ThunkResult } from 'app/types';
@@ -28,7 +28,9 @@ export function createNotificationChannel(data: any): ThunkResult<Promise<void>>
       dispatch(notifyApp(createSuccessNotification('Notification created')));
       locationService.push('/alerting/notifications');
     } catch (error) {
-      dispatch(notifyApp(createErrorNotification(error.data.error)));
+      if (isFetchError(error)) {
+        dispatch(notifyApp(createErrorNotification(error.data.error)));
+      }
     }
   };
 }
@@ -39,7 +41,9 @@ export function updateNotificationChannel(data: any): ThunkResult<void> {
       await getBackendSrv().put(`/api/alert-notifications/${data.id}`, data);
       dispatch(notifyApp(createSuccessNotification('Notification updated')));
     } catch (error) {
-      dispatch(notifyApp(createErrorNotification(error.data.error)));
+      if (isFetchError(error)) {
+        dispatch(notifyApp(createErrorNotification(error.data.error)));
+      }
     }
   };
 }
diff --git a/public/app/features/alerting/unified/api/alertmanager.ts b/public/app/features/alerting/unified/api/alertmanager.ts
index 28649614ab8..78a4385bdc1 100644
--- a/public/app/features/alerting/unified/api/alertmanager.ts
+++ b/public/app/features/alerting/unified/api/alertmanager.ts
@@ -1,7 +1,7 @@
 import { lastValueFrom } from 'rxjs';
 
 import { urlUtil } from '@grafana/data';
-import { getBackendSrv } from '@grafana/runtime';
+import { getBackendSrv, isFetchError } from '@grafana/runtime';
 import {
   AlertmanagerAlert,
   AlertManagerCortexConfig,
@@ -18,7 +18,6 @@ import {
   ExternalAlertmanagerConfig,
 } from 'app/plugins/datasource/alertmanager/types';
 
-import { isFetchError } from '../utils/alertmanager';
 import { getDatasourceAPIUid, GRAFANA_RULES_SOURCE_NAME } from '../utils/datasource';
 
 // "grafana" for grafana-managed, otherwise a datasource name
@@ -39,6 +38,7 @@ export async function fetchAlertManagerConfig(alertManagerSourceName: string): P
     // if no config has been uploaded to grafana, it returns error instead of latest config
     if (
       alertManagerSourceName === GRAFANA_RULES_SOURCE_NAME &&
+      isFetchError(e) &&
       e.data?.message?.includes('could not find an Alertmanager configuration')
     ) {
       return {
diff --git a/public/app/features/alerting/unified/api/buildInfo.test.ts b/public/app/features/alerting/unified/api/buildInfo.test.ts
index 1bbbafcc220..b01af7f763e 100644
--- a/public/app/features/alerting/unified/api/buildInfo.test.ts
+++ b/public/app/features/alerting/unified/api/buildInfo.test.ts
@@ -12,6 +12,7 @@ jest.mock('./prometheus');
 jest.mock('./ruler');
 jest.mock('app/core/services/context_srv', () => {});
 jest.mock('@grafana/runtime', () => ({
+  ...jest.requireActual('@grafana/runtime'),
   getBackendSrv: () => ({ fetch }),
 }));
 
diff --git a/public/app/features/alerting/unified/api/buildInfo.ts b/public/app/features/alerting/unified/api/buildInfo.ts
index cc5a06039a1..cc623411e5e 100644
--- a/public/app/features/alerting/unified/api/buildInfo.ts
+++ b/public/app/features/alerting/unified/api/buildInfo.ts
@@ -1,9 +1,8 @@
 import { lastValueFrom } from 'rxjs';
 
-import { getBackendSrv } from '@grafana/runtime';
+import { getBackendSrv, isFetchError } from '@grafana/runtime';
 import { PromApplication, PromApiFeatures, PromBuildInfoResponse } from 'app/types/unified-alerting-dto';
 
-import { isFetchError } from '../utils/alertmanager';
 import { RULER_NOT_SUPPORTED_MSG } from '../utils/constants';
 import { getDataSourceByName } from '../utils/datasource';
 
diff --git a/public/app/features/alerting/unified/components/admin/AlertmanagerConfig.tsx b/public/app/features/alerting/unified/components/admin/AlertmanagerConfig.tsx
index fdf286df090..bdb3e0cc5cb 100644
--- a/public/app/features/alerting/unified/components/admin/AlertmanagerConfig.tsx
+++ b/public/app/features/alerting/unified/components/admin/AlertmanagerConfig.tsx
@@ -112,7 +112,7 @@ export default function AlertmanagerConfig(): JSX.Element {
                           JSON.parse(v);
                           return true;
                         } catch (e) {
-                          return e.message;
+                          return e instanceof Error ? e.message : 'Invalid JSON.';
                         }
                       },
                     })}
diff --git a/public/app/features/alerting/unified/utils/alertmanager.ts b/public/app/features/alerting/unified/utils/alertmanager.ts
index d569c32442a..90a892a4703 100644
--- a/public/app/features/alerting/unified/utils/alertmanager.ts
+++ b/public/app/features/alerting/unified/utils/alertmanager.ts
@@ -1,5 +1,4 @@
 import { SelectableValue } from '@grafana/data';
-import { FetchError } from '@grafana/runtime';
 import {
   AlertManagerCortexConfig,
   MatcherOperator,
@@ -260,7 +259,3 @@ export function getMonthsString(months?: string[]): string {
 export function getYearsString(years?: string[]): string {
   return 'Years: ' + (years?.join(', ') ?? 'All');
 }
-
-export function isFetchError(e: unknown): e is FetchError {
-  return typeof e === 'object' && e !== null && 'status' in e && 'data' in e;
-}
diff --git a/public/app/features/alerting/unified/utils/redux.ts b/public/app/features/alerting/unified/utils/redux.ts
index d1eba541758..193d2a0774d 100644
--- a/public/app/features/alerting/unified/utils/redux.ts
+++ b/public/app/features/alerting/unified/utils/redux.ts
@@ -1,11 +1,9 @@
 import { AsyncThunk, createSlice, Draft, isAsyncThunkAction, PayloadAction, SerializedError } from '@reduxjs/toolkit';
 
 import { AppEvents } from '@grafana/data';
-import { FetchError } from '@grafana/runtime';
+import { FetchError, isFetchError } from '@grafana/runtime';
 import { appEvents } from 'app/core/core';
 
-import { isFetchError } from './alertmanager';
-
 export interface AsyncRequestState<T> {
   result?: T;
   loading: boolean;
diff --git a/public/app/features/dashboard/components/DashboardSettings/AutoRefreshIntervals.tsx b/public/app/features/dashboard/components/DashboardSettings/AutoRefreshIntervals.tsx
index fa9ec12888b..9a87edae572 100644
--- a/public/app/features/dashboard/components/DashboardSettings/AutoRefreshIntervals.tsx
+++ b/public/app/features/dashboard/components/DashboardSettings/AutoRefreshIntervals.tsx
@@ -82,7 +82,7 @@ export const validateIntervals = (
     getValidIntervals(intervals, dependencies);
     return null;
   } catch (err) {
-    return err.message;
+    return err instanceof Error ? err.message : 'Invalid intervals';
   }
 };
 
diff --git a/public/app/features/dashboard/components/PanelEditor/PanelEditor.tsx b/public/app/features/dashboard/components/PanelEditor/PanelEditor.tsx
index 8221172b50e..076ccffda0e 100644
--- a/public/app/features/dashboard/components/PanelEditor/PanelEditor.tsx
+++ b/public/app/features/dashboard/components/PanelEditor/PanelEditor.tsx
@@ -6,7 +6,7 @@ import { Subscription } from 'rxjs';
 
 import { FieldConfigSource, GrafanaTheme2 } from '@grafana/data';
 import { selectors } from '@grafana/e2e-selectors';
-import { locationService } from '@grafana/runtime';
+import { isFetchError, locationService } from '@grafana/runtime';
 import {
   HorizontalGroup,
   InlineSwitch,
@@ -163,7 +163,9 @@ export class PanelEditorUnconnected extends PureComponent<Props> {
         await saveAndRefreshLibraryPanel(this.props.panel, this.props.dashboard.meta.folderId!);
         this.props.notifyApp(createPanelLibrarySuccessNotification('Library panel saved'));
       } catch (err) {
-        this.props.notifyApp(createPanelLibraryErrorNotification(`Error saving library panel: "${err.statusText}"`));
+        if (isFetchError(err)) {
+          this.props.notifyApp(createPanelLibraryErrorNotification(`Error saving library panel: "${err.statusText}"`));
+        }
       }
       return;
     }
diff --git a/public/app/features/dashboard/components/SaveDashboard/forms/SaveDashboardAsForm.tsx b/public/app/features/dashboard/components/SaveDashboard/forms/SaveDashboardAsForm.tsx
index b1176a0808e..283ea733e9d 100644
--- a/public/app/features/dashboard/components/SaveDashboard/forms/SaveDashboardAsForm.tsx
+++ b/public/app/features/dashboard/components/SaveDashboard/forms/SaveDashboardAsForm.tsx
@@ -64,7 +64,7 @@ export const SaveDashboardAsForm: React.FC<SaveDashboardAsFormProps> = ({
       await validationSrv.validateNewDashboardName(getFormValues().$folder.id, dashboardName);
       return true;
     } catch (e) {
-      return e.message;
+      return e instanceof Error ? e.message : 'Dashboard name is invalid';
     }
   };
 
diff --git a/public/app/features/dashboard/state/initDashboard.test.ts b/public/app/features/dashboard/state/initDashboard.test.ts
index eae72482c81..219d67bb011 100644
--- a/public/app/features/dashboard/state/initDashboard.test.ts
+++ b/public/app/features/dashboard/state/initDashboard.test.ts
@@ -2,7 +2,7 @@ import configureMockStore from 'redux-mock-store';
 import thunk from 'redux-thunk';
 import { Subject } from 'rxjs';
 
-import { locationService, setEchoSrv } from '@grafana/runtime';
+import { FetchError, locationService, setEchoSrv } from '@grafana/runtime';
 import { getBackendSrv } from 'app/core/services/backend_srv';
 import { keybindingSrv } from 'app/core/services/keybindingSrv';
 import { variableAdapters } from 'app/features/variables/adapters';
@@ -208,7 +208,15 @@ describeInitScenario('Initializing home dashboard', (ctx) => {
 describeInitScenario('Initializing home dashboard cancelled', (ctx) => {
   ctx.setup(() => {
     ctx.args.routeName = DashboardRoutes.Home;
-    ctx.backendSrv.get.mockRejectedValue({ cancelled: true });
+    const fetchError: FetchError = {
+      cancelled: true,
+      config: {
+        url: '/api/dashboards/home',
+      },
+      data: 'foo',
+      status: 500,
+    };
+    ctx.backendSrv.get.mockRejectedValue(fetchError);
   });
 
   it('Should abort init process', () => {
diff --git a/public/app/features/dashboard/state/initDashboard.ts b/public/app/features/dashboard/state/initDashboard.ts
index 396148797e6..ddd7fdc7dc2 100644
--- a/public/app/features/dashboard/state/initDashboard.ts
+++ b/public/app/features/dashboard/state/initDashboard.ts
@@ -1,5 +1,5 @@
 import { locationUtil, setWeekStart } from '@grafana/data';
-import { config, locationService } from '@grafana/runtime';
+import { config, isFetchError, locationService } from '@grafana/runtime';
 import { notifyApp } from 'app/core/actions';
 import { createErrorNotification } from 'app/core/copy/appNotification';
 import { backendSrv } from 'app/core/services/backend_srv';
@@ -90,7 +90,7 @@ async function fetchDashboard(
     }
   } catch (err) {
     // Ignore cancelled errors
-    if (err.cancelled) {
+    if (isFetchError(err) && err.cancelled) {
       return null;
     }
 
@@ -184,7 +184,9 @@ export function initDashboard(args: InitDashboardArgs): ThunkResult<void> {
 
       keybindingSrv.setupDashboardBindings(dashboard);
     } catch (err) {
-      dispatch(notifyApp(createErrorNotification('Dashboard init failed', err)));
+      if (err instanceof Error) {
+        dispatch(notifyApp(createErrorNotification('Dashboard init failed', err)));
+      }
       console.error(err);
     }
 
diff --git a/public/app/features/datasources/state/actions.test.ts b/public/app/features/datasources/state/actions.test.ts
index 84e6ca9c108..8425aeb836f 100644
--- a/public/app/features/datasources/state/actions.test.ts
+++ b/public/app/features/datasources/state/actions.test.ts
@@ -1,7 +1,7 @@
 import { of } from 'rxjs';
 import { thunkTester } from 'test/core/thunk/thunkTester';
 
-import { BackendSrvRequest, FetchResponse } from '@grafana/runtime';
+import { BackendSrvRequest, FetchError, FetchResponse } from '@grafana/runtime';
 import { getBackendSrv } from 'app/core/services/backend_srv';
 import { ThunkResult, ThunkDispatch } from 'app/types';
 
@@ -316,13 +316,17 @@ describe('testDataSource', () => {
 
     it('then testDataSourceFailed should be dispatched with response error message', async () => {
       const result = {
-        message: 'Error testing datasource',
+        message: 'Response error message',
       };
-      const dispatchedActions = await failDataSourceTest({
-        message: 'Error testing datasource',
+      const error: FetchError = {
+        config: {
+          url: '',
+        },
         data: { message: 'Response error message' },
+        status: 400,
         statusText: 'Bad Request',
-      });
+      };
+      const dispatchedActions = await failDataSourceTest(error);
       expect(dispatchedActions).toEqual([testDataSourceStarting(), testDataSourceFailed(result)]);
     });
 
@@ -330,10 +334,15 @@ describe('testDataSource', () => {
       const result = {
         message: 'Response error message',
       };
-      const dispatchedActions = await failDataSourceTest({
+      const error: FetchError = {
+        config: {
+          url: '',
+        },
         data: { message: 'Response error message' },
+        status: 400,
         statusText: 'Bad Request',
-      });
+      };
+      const dispatchedActions = await failDataSourceTest(error);
       expect(dispatchedActions).toEqual([testDataSourceStarting(), testDataSourceFailed(result)]);
     });
 
@@ -341,7 +350,15 @@ describe('testDataSource', () => {
       const result = {
         message: 'HTTP error Bad Request',
       };
-      const dispatchedActions = await failDataSourceTest({ data: {}, statusText: 'Bad Request' });
+      const error: FetchError = {
+        config: {
+          url: '',
+        },
+        data: {},
+        statusText: 'Bad Request',
+        status: 400,
+      };
+      const dispatchedActions = await failDataSourceTest(error);
       expect(dispatchedActions).toEqual([testDataSourceStarting(), testDataSourceFailed(result)]);
     });
   });
diff --git a/public/app/features/datasources/state/actions.ts b/public/app/features/datasources/state/actions.ts
index 9dd8d5d26e9..a95d07cb030 100644
--- a/public/app/features/datasources/state/actions.ts
+++ b/public/app/features/datasources/state/actions.ts
@@ -1,7 +1,14 @@
 import { lastValueFrom } from 'rxjs';
 
 import { DataSourcePluginMeta, DataSourceSettings, locationUtil } from '@grafana/data';
-import { DataSourceWithBackend, getDataSourceSrv, locationService } from '@grafana/runtime';
+import {
+  DataSourceWithBackend,
+  getDataSourceSrv,
+  HealthCheckError,
+  HealthCheckResultDetails,
+  isFetchError,
+  locationService,
+} from '@grafana/runtime';
 import { updateNavIndex } from 'app/core/actions';
 import { getBackendSrv } from 'app/core/services/backend_srv';
 import { accessControlQueryParam } from 'app/core/utils/accessControl';
@@ -77,7 +84,9 @@ export const initDataSourceSettings = (
 
       dispatch(initDataSourceSettingsSucceeded(importedPlugin));
     } catch (err) {
-      dispatch(initDataSourceSettingsFailed(err));
+      if (err instanceof Error) {
+        dispatch(initDataSourceSettingsFailed(err));
+      }
     }
   };
 };
@@ -104,9 +113,17 @@ export const testDataSource = (
 
         dispatch(testDataSourceSucceeded(result));
       } catch (err) {
-        const { statusText, message: errMessage, details, data } = err;
+        let message: string | undefined;
+        let details: HealthCheckResultDetails;
 
-        const message = errMessage || data?.message || 'HTTP error ' + statusText;
+        if (err instanceof HealthCheckError) {
+          message = err.message;
+          details = err.details;
+        } else if (isFetchError(err)) {
+          message = err.data.message ?? `HTTP error ${err.statusText}`;
+        } else if (err instanceof Error) {
+          message = err.message;
+        }
 
         dispatch(testDataSourceFailed({ message, details }));
       }
diff --git a/public/app/features/folders/state/actions.ts b/public/app/features/folders/state/actions.ts
index 1a754a5a8c7..a1abd069fe7 100644
--- a/public/app/features/folders/state/actions.ts
+++ b/public/app/features/folders/state/actions.ts
@@ -1,7 +1,7 @@
 import { lastValueFrom } from 'rxjs';
 
 import { locationUtil } from '@grafana/data';
-import { getBackendSrv, locationService } from '@grafana/runtime';
+import { getBackendSrv, isFetchError, locationService } from '@grafana/runtime';
 import { notifyApp, updateNavIndex } from 'app/core/actions';
 import { createSuccessNotification, createWarningNotification } from 'app/core/copy/appNotification';
 import { contextSrv } from 'app/core/core';
@@ -59,7 +59,7 @@ export function checkFolderPermissions(uid: string): ThunkResult<void> {
       );
       dispatch(setCanViewFolderPermissions(true));
     } catch (err) {
-      if (err.status !== 403) {
+      if (isFetchError(err) && err.status !== 403) {
         dispatch(notifyApp(createWarningNotification('Error checking folder permissions', err.data?.message)));
       }
 
diff --git a/public/app/features/library-panels/components/AddLibraryPanelModal/AddLibraryPanelModal.tsx b/public/app/features/library-panels/components/AddLibraryPanelModal/AddLibraryPanelModal.tsx
index 7173d22125f..3aee558d73f 100644
--- a/public/app/features/library-panels/components/AddLibraryPanelModal/AddLibraryPanelModal.tsx
+++ b/public/app/features/library-panels/components/AddLibraryPanelModal/AddLibraryPanelModal.tsx
@@ -1,6 +1,7 @@
 import React, { useCallback, useEffect, useState } from 'react';
 import { useAsync, useDebounce } from 'react-use';
 
+import { isFetchError } from '@grafana/runtime';
 import { Button, Field, Input, Modal } from '@grafana/ui';
 import { FolderPicker } from 'app/core/components/Select/FolderPicker';
 
@@ -36,7 +37,9 @@ export const AddLibraryPanelContents = ({ panel, initialFolderId, onDismiss }: A
     try {
       return !(await getLibraryPanelByName(panelName)).some((lp) => lp.folderId === folderId);
     } catch (err) {
-      err.isHandled = true;
+      if (isFetchError(err)) {
+        err.isHandled = true;
+      }
       return true;
     } finally {
       setWaiting(false);
diff --git a/public/app/features/library-panels/utils/usePanelSave.ts b/public/app/features/library-panels/utils/usePanelSave.ts
index 90bb0e468a6..d20fdc01f3e 100644
--- a/public/app/features/library-panels/utils/usePanelSave.ts
+++ b/public/app/features/library-panels/utils/usePanelSave.ts
@@ -2,6 +2,7 @@ import { useEffect } from 'react';
 import { useDispatch } from 'react-redux';
 import useAsyncFn from 'react-use/lib/useAsyncFn';
 
+import { isFetchError } from '@grafana/runtime';
 import { notifyApp } from 'app/core/actions';
 import { PanelModel } from 'app/features/dashboard/state';
 
@@ -17,8 +18,11 @@ export const usePanelSave = () => {
     try {
       return await saveAndRefreshLibraryPanel(panel, folderId);
     } catch (err) {
-      err.isHandled = true;
-      throw new Error(err.data.message);
+      if (isFetchError(err)) {
+        err.isHandled = true;
+        throw new Error(err.data.message);
+      }
+      throw err;
     }
   }, []);
 
diff --git a/public/app/features/manage-dashboards/DashboardImportPage.tsx b/public/app/features/manage-dashboards/DashboardImportPage.tsx
index 9ea96938469..1085441536a 100644
--- a/public/app/features/manage-dashboards/DashboardImportPage.tsx
+++ b/public/app/features/manage-dashboards/DashboardImportPage.tsx
@@ -84,10 +84,12 @@ class UnthemedDashboardImport extends PureComponent<Props> {
           try {
             dashboard = JSON.parse(e.target.result);
           } catch (error) {
-            appEvents.emit(AppEvents.alertError, [
-              'Import failed',
-              'JSON -> JS Serialization failed: ' + error.message,
-            ]);
+            if (error instanceof Error) {
+              appEvents.emit(AppEvents.alertError, [
+                'Import failed',
+                'JSON -> JS Serialization failed: ' + error.message,
+              ]);
+            }
             return;
           }
           importDashboardJson(dashboard);
diff --git a/public/app/features/manage-dashboards/state/actions.ts b/public/app/features/manage-dashboards/state/actions.ts
index e5d23f4c87b..23d0b18527e 100644
--- a/public/app/features/manage-dashboards/state/actions.ts
+++ b/public/app/features/manage-dashboards/state/actions.ts
@@ -1,5 +1,5 @@
 import { DataSourceInstanceSettings, locationUtil } from '@grafana/data';
-import { getDataSourceSrv, locationService, getBackendSrv } from '@grafana/runtime';
+import { getDataSourceSrv, locationService, getBackendSrv, isFetchError } from '@grafana/runtime';
 import { notifyApp } from 'app/core/actions';
 import { createErrorNotification } from 'app/core/copy/appNotification';
 import { dashboardWatcher } from 'app/features/live/dashboard/dashboardWatcher';
@@ -34,7 +34,9 @@ export function fetchGcomDashboard(id: string): ThunkResult<void> {
       dispatch(processElements(dashboard.json));
     } catch (error) {
       dispatch(fetchFailed());
-      dispatch(notifyApp(createErrorNotification(error.data.message || error)));
+      if (isFetchError(error)) {
+        dispatch(notifyApp(createErrorNotification(error.data.message || error)));
+      }
     }
   };
 }
@@ -213,11 +215,13 @@ async function moveDashboard(uid: string, toFolder: FolderInfo) {
     await saveDashboard(options);
     return { succeeded: true };
   } catch (err) {
-    if (err.data?.status !== 'plugin-dashboard') {
-      return { succeeded: false };
-    }
+    if (isFetchError(err)) {
+      if (err.data?.status !== 'plugin-dashboard') {
+        return { succeeded: false };
+      }
 
-    err.isHandled = true;
+      err.isHandled = true;
+    }
     options.overwrite = true;
 
     try {
diff --git a/public/app/features/playlist/api.ts b/public/app/features/playlist/api.ts
index 4474d8970e3..570e4a65171 100644
--- a/public/app/features/playlist/api.ts
+++ b/public/app/features/playlist/api.ts
@@ -33,6 +33,8 @@ async function withErrorHandling(apiCall: () => Promise<void>, message = 'Playli
     await apiCall();
     dispatch(notifyApp(createSuccessNotification(message)));
   } catch (e) {
-    dispatch(notifyApp(createErrorNotification('Unable to save playlist', e)));
+    if (e instanceof Error) {
+      dispatch(notifyApp(createErrorNotification('Unable to save playlist', e)));
+    }
   }
 }
diff --git a/public/app/features/plugins/admin/api.ts b/public/app/features/plugins/admin/api.ts
index 949209b42bc..5aa840276ae 100644
--- a/public/app/features/plugins/admin/api.ts
+++ b/public/app/features/plugins/admin/api.ts
@@ -1,5 +1,5 @@
 import { PluginError, PluginMeta, renderMarkdown } from '@grafana/data';
-import { getBackendSrv } from '@grafana/runtime';
+import { getBackendSrv, isFetchError } from '@grafana/runtime';
 
 import { API_ROOT, GCOM_API_ROOT } from './constants';
 import { isLocalPluginVisible, isRemotePluginVisible } from './helpers';
@@ -45,8 +45,10 @@ async function getRemotePlugin(id: string): Promise<RemotePlugin | undefined> {
   try {
     return await getBackendSrv().get(`${GCOM_API_ROOT}/plugins/${id}`, {});
   } catch (error) {
-    // It can happen that GCOM is not available, in that case we show a limited set of information to the user.
-    error.isHandled = true;
+    if (isFetchError(error)) {
+      // It can happen that GCOM is not available, in that case we show a limited set of information to the user.
+      error.isHandled = true;
+    }
     return;
   }
 }
@@ -66,8 +68,10 @@ async function getPluginVersions(id: string, isPublished: boolean): Promise<Vers
       grafanaDependency: v.grafanaDependency,
     }));
   } catch (error) {
-    // It can happen that GCOM is not available, in that case we show a limited set of information to the user.
-    error.isHandled = true;
+    if (isFetchError(error)) {
+      // It can happen that GCOM is not available, in that case we show a limited set of information to the user.
+      error.isHandled = true;
+    }
     return [];
   }
 }
@@ -79,7 +83,9 @@ async function getLocalPluginReadme(id: string): Promise<string> {
 
     return markdownAsHtml;
   } catch (error) {
-    error.isHandled = true;
+    if (isFetchError(error)) {
+      error.isHandled = true;
+    }
     return '';
   }
 }
diff --git a/public/app/features/plugins/admin/state/actions.ts b/public/app/features/plugins/admin/state/actions.ts
index 408f1d38833..767d2f27b63 100644
--- a/public/app/features/plugins/admin/state/actions.ts
+++ b/public/app/features/plugins/admin/state/actions.ts
@@ -1,7 +1,7 @@
 import { createAction, createAsyncThunk, Update } from '@reduxjs/toolkit';
 
 import { PanelPlugin } from '@grafana/data';
-import { getBackendSrv } from '@grafana/runtime';
+import { getBackendSrv, isFetchError } from '@grafana/runtime';
 import { importPanelPlugin } from 'app/features/plugins/importPanelPlugin';
 import { StoreState, ThunkResult } from 'app/types';
 
@@ -39,7 +39,9 @@ export const fetchRemotePlugins = createAsyncThunk<RemotePlugin[], void, { rejec
     try {
       return await getRemotePlugins();
     } catch (error) {
-      error.isHandled = true;
+      if (isFetchError(error)) {
+        error.isHandled = true;
+      }
       return thunkApi.rejectWithValue([]);
     }
   }
diff --git a/public/app/features/plugins/datasource_srv.ts b/public/app/features/plugins/datasource_srv.ts
index 6eb54233043..a60ad1b8f91 100644
--- a/public/app/features/plugins/datasource_srv.ts
+++ b/public/app/features/plugins/datasource_srv.ts
@@ -191,7 +191,9 @@ export class DatasourceSrv implements DataSourceService {
       this.datasources[instance.uid] = instance;
       return instance;
     } catch (err) {
-      appEvents.emit(AppEvents.alertError, [instanceSettings.name + ' plugin failed', err.toString()]);
+      if (err instanceof Error) {
+        appEvents.emit(AppEvents.alertError, [instanceSettings.name + ' plugin failed', err.toString()]);
+      }
       return Promise.reject({ message: `Datasource: ${key} was not found` });
     }
   }
diff --git a/public/app/features/variables/query/actions.test.tsx b/public/app/features/variables/query/actions.test.tsx
index a7f2d2a07e2..36c3875f27b 100644
--- a/public/app/features/variables/query/actions.test.tsx
+++ b/public/app/features/variables/query/actions.test.tsx
@@ -211,7 +211,7 @@ describe('query actions', () => {
     silenceConsoleOutput();
     it('then correct actions are dispatched', async () => {
       const variable = createVariable({ includeAll: true });
-      const error = { message: 'failed to fetch metrics' };
+      const error = new Error('failed to fetch metrics');
 
       mocks[variable.datasource!.uid!].metricFindQuery = jest.fn(() => Promise.reject(error));
 
@@ -233,10 +233,7 @@ describe('query actions', () => {
           toKeyedAction('key', addVariableEditorError({ errorProp: 'update', errorText: error.message }))
         );
         expect(dispatchedActions[3]).toEqual(
-          toKeyedAction(
-            'key',
-            variableStateFailed(toVariablePayload(variable, { error: { message: 'failed to fetch metrics' } }))
-          )
+          toKeyedAction('key', variableStateFailed(toVariablePayload(variable, { error })))
         );
         expect(dispatchedActions[4].type).toEqual(notifyApp.type);
         expect(dispatchedActions[4].payload.title).toEqual('Templating [0]');
diff --git a/public/app/features/variables/query/actions.ts b/public/app/features/variables/query/actions.ts
index f2aca6b6e59..a2c52ac487d 100644
--- a/public/app/features/variables/query/actions.ts
+++ b/public/app/features/variables/query/actions.ts
@@ -47,15 +47,17 @@ export const updateQueryVariableOptions = (
         getVariableQueryRunner().queueRequest({ identifier, datasource, searchFilter });
       });
     } catch (err) {
-      const error = toDataQueryError(err);
-      const { rootStateKey } = identifier;
-      if (getVariablesState(rootStateKey, getState()).editor.id === identifier.id) {
-        dispatch(
-          toKeyedAction(rootStateKey, addVariableEditorError({ errorProp: 'update', errorText: error.message }))
-        );
-      }
+      if (err instanceof Error) {
+        const error = toDataQueryError(err);
+        const { rootStateKey } = identifier;
+        if (getVariablesState(rootStateKey, getState()).editor.id === identifier.id) {
+          dispatch(
+            toKeyedAction(rootStateKey, addVariableEditorError({ errorProp: 'update', errorText: error.message }))
+          );
+        }
 
-      throw error;
+        throw error;
+      }
     }
   };
 };
diff --git a/public/app/plugins/datasource/cloudwatch/components/ConfigEditor.tsx b/public/app/plugins/datasource/cloudwatch/components/ConfigEditor.tsx
index 5dc682a3a36..7d54e625375 100644
--- a/public/app/plugins/datasource/cloudwatch/components/ConfigEditor.tsx
+++ b/public/app/plugins/datasource/cloudwatch/components/ConfigEditor.tsx
@@ -116,7 +116,9 @@ function useTimoutValidation(value: string | undefined) {
           rangeUtil.describeInterval(value);
           setErr(undefined);
         } catch (e) {
-          setErr(e.toString());
+          if (e instanceof Error) {
+            setErr(e.toString());
+          }
         }
       } else {
         setErr(undefined);
diff --git a/public/app/plugins/datasource/grafana-azure-monitor-datasource/azure_monitor/azure_monitor_datasource.ts b/public/app/plugins/datasource/grafana-azure-monitor-datasource/azure_monitor/azure_monitor_datasource.ts
index b9cf3a51899..f712f119ff8 100644
--- a/public/app/plugins/datasource/grafana-azure-monitor-datasource/azure_monitor/azure_monitor_datasource.ts
+++ b/public/app/plugins/datasource/grafana-azure-monitor-datasource/azure_monitor/azure_monitor_datasource.ts
@@ -1,7 +1,7 @@
 import { filter, find, startsWith } from 'lodash';
 
 import { DataSourceInstanceSettings, ScopedVars } from '@grafana/data';
-import { DataSourceWithBackend, getTemplateSrv } from '@grafana/runtime';
+import { DataSourceWithBackend, getTemplateSrv, isFetchError } from '@grafana/runtime';
 import { getTimeSrv, TimeSrv } from 'app/features/dashboard/services/TimeSrv';
 
 import { resourceTypeDisplayNames } from '../azureMetadata';
@@ -314,14 +314,18 @@ export default class AzureMonitorDatasource extends DataSourceWithBackend<AzureM
       });
     } catch (e) {
       let message = 'Azure Monitor: ';
-      message += e.statusText ? e.statusText + ': ' : '';
+      if (isFetchError(e)) {
+        message += e.statusText ? e.statusText + ': ' : '';
 
-      if (e.data && e.data.error && e.data.error.code) {
-        message += e.data.error.code + '. ' + e.data.error.message;
-      } else if (e.data && e.data.error) {
-        message += e.data.error;
-      } else if (e.data) {
-        message += e.data;
+        if (e.data && e.data.error && e.data.error.code) {
+          message += e.data.error.code + '. ' + e.data.error.message;
+        } else if (e.data && e.data.error) {
+          message += e.data.error;
+        } else if (e.data) {
+          message += e.data;
+        } else {
+          message += 'Cannot connect to Azure Monitor REST API.';
+        }
       } else {
         message += 'Cannot connect to Azure Monitor REST API.';
       }
diff --git a/public/app/plugins/datasource/grafana-azure-monitor-datasource/components/ConfigEditor.tsx b/public/app/plugins/datasource/grafana-azure-monitor-datasource/components/ConfigEditor.tsx
index a4ea6ce39d9..826f5d753af 100644
--- a/public/app/plugins/datasource/grafana-azure-monitor-datasource/components/ConfigEditor.tsx
+++ b/public/app/plugins/datasource/grafana-azure-monitor-datasource/components/ConfigEditor.tsx
@@ -1,7 +1,7 @@
 import React, { PureComponent } from 'react';
 
 import { DataSourcePluginOptionsEditorProps, SelectableValue, updateDatasourcePluginOption } from '@grafana/data';
-import { getBackendSrv, getTemplateSrv, TemplateSrv } from '@grafana/runtime';
+import { getBackendSrv, getTemplateSrv, isFetchError, TemplateSrv } from '@grafana/runtime';
 import { Alert } from '@grafana/ui';
 
 import ResponseParser from '../azure_monitor/response_parser';
@@ -70,13 +70,15 @@ export class ConfigEditor extends PureComponent<Props, State> {
       this.setState({ error: undefined });
       return ResponseParser.parseSubscriptionsForSelect(result);
     } catch (err) {
-      this.setState({
-        error: {
-          title: 'Error requesting subscriptions',
-          description: 'Could not request subscriptions from Azure. Check your credentials and try again.',
-          details: err?.data?.message,
-        },
-      });
+      if (isFetchError(err)) {
+        this.setState({
+          error: {
+            title: 'Error requesting subscriptions',
+            description: 'Could not request subscriptions from Azure. Check your credentials and try again.',
+            details: err?.data?.message,
+          },
+        });
+      }
       return Promise.resolve([]);
     }
   };
diff --git a/public/app/plugins/datasource/grafana-azure-monitor-datasource/resourcePicker/resourcePickerData.test.ts b/public/app/plugins/datasource/grafana-azure-monitor-datasource/resourcePicker/resourcePickerData.test.ts
index 49ac840360e..f41dff6c687 100644
--- a/public/app/plugins/datasource/grafana-azure-monitor-datasource/resourcePicker/resourcePickerData.test.ts
+++ b/public/app/plugins/datasource/grafana-azure-monitor-datasource/resourcePicker/resourcePickerData.test.ts
@@ -93,7 +93,11 @@ describe('AzureMonitor resourcePickerData', () => {
         await resourcePickerData.getSubscriptions();
         throw Error('expected getSubscriptions to fail but it succeeded');
       } catch (err) {
-        expect(err.message).toEqual('No subscriptions were found');
+        if (err instanceof Error) {
+          expect(err.message).toEqual('No subscriptions were found');
+        } else {
+          throw err;
+        }
       }
     });
   });
@@ -178,7 +182,11 @@ describe('AzureMonitor resourcePickerData', () => {
         await resourcePickerData.getResourceGroupsBySubscriptionId('123');
         throw Error('expected getResourceGroupsBySubscriptionId to fail but it succeeded');
       } catch (err) {
-        expect(err.message).toEqual('unable to fetch resource groups');
+        if (err instanceof Error) {
+          expect(err.message).toEqual('unable to fetch resource groups');
+        } else {
+          throw err;
+        }
       }
     });
   });
@@ -232,7 +240,11 @@ describe('AzureMonitor resourcePickerData', () => {
         await resourcePickerData.getResourcesForResourceGroup('dev');
         throw Error('expected getResourcesForResourceGroup to fail but it succeeded');
       } catch (err) {
-        expect(err.message).toEqual('unable to fetch resource details');
+        if (err instanceof Error) {
+          expect(err.message).toEqual('unable to fetch resource details');
+        } else {
+          throw err;
+        }
       }
     });
   });
@@ -317,7 +329,11 @@ describe('AzureMonitor resourcePickerData', () => {
         await resourcePickerData.search('dev', 'logs');
         throw Error('expected search test to fail but it succeeded');
       } catch (err) {
-        expect(err.message).toEqual('unable to fetch resource details');
+        if (err instanceof Error) {
+          expect(err.message).toEqual('unable to fetch resource details');
+        } else {
+          throw err;
+        }
       }
     });
   });
diff --git a/public/app/plugins/datasource/graphite/graphite_query.ts b/public/app/plugins/datasource/graphite/graphite_query.ts
index 40232d19dfe..ac38010a0f1 100644
--- a/public/app/plugins/datasource/graphite/graphite_query.ts
+++ b/public/app/plugins/datasource/graphite/graphite_query.ts
@@ -79,8 +79,10 @@ export default class GraphiteQuery {
     try {
       this.parseTargetRecursive(astNode, null);
     } catch (err) {
-      console.error('error parsing target:', err.message);
-      this.error = err.message;
+      if (err instanceof Error) {
+        console.error('error parsing target:', err.message);
+        this.error = err.message;
+      }
       this.target.textEditor = true;
     }
 
diff --git a/public/app/plugins/datasource/graphite/parser.ts b/public/app/plugins/datasource/graphite/parser.ts
index b276ee20325..8eee34554e1 100644
--- a/public/app/plugins/datasource/graphite/parser.ts
+++ b/public/app/plugins/datasource/graphite/parser.ts
@@ -1,4 +1,6 @@
 import { Lexer } from './lexer';
+import { GraphiteParserError } from './types';
+import { isGraphiteParserError } from './utils';
 
 export class Parser {
   expression: any;
@@ -21,11 +23,13 @@ export class Parser {
     try {
       return this.functionCall() || this.metricExpression();
     } catch (e) {
-      return {
-        type: 'error',
-        message: e.message,
-        pos: e.pos,
-      };
+      if (isGraphiteParserError(e)) {
+        return {
+          type: 'error',
+          message: e.message,
+          pos: e.pos,
+        };
+      }
     }
   }
 
@@ -222,7 +226,11 @@ export class Parser {
 
     const token = this.consumeToken();
     if (token.isUnclosed) {
-      throw { message: 'Unclosed string parameter', pos: token.pos };
+      const error: GraphiteParserError = {
+        message: 'Unclosed string parameter',
+        pos: token.pos,
+      };
+      throw error;
     }
 
     return {
@@ -234,10 +242,11 @@ export class Parser {
   errorMark(text: string) {
     const currentToken = this.tokens[this.index];
     const type = currentToken ? currentToken.type : 'end of string';
-    throw {
+    const error: GraphiteParserError = {
       message: text + ' instead found ' + type,
       pos: currentToken ? currentToken.pos : this.lexer.char,
     };
+    throw error;
   }
 
   // returns token value and incre
diff --git a/public/app/plugins/datasource/graphite/state/helpers.ts b/public/app/plugins/datasource/graphite/state/helpers.ts
index 3378edf16a2..0f58be18135 100644
--- a/public/app/plugins/datasource/graphite/state/helpers.ts
+++ b/public/app/plugins/datasource/graphite/state/helpers.ts
@@ -90,7 +90,9 @@ export async function checkOtherSegments(
       }
     }
   } catch (err) {
-    handleMetricsAutoCompleteError(state, err);
+    if (err instanceof Error) {
+      handleMetricsAutoCompleteError(state, err);
+    }
   }
 }
 
diff --git a/public/app/plugins/datasource/graphite/state/providers.ts b/public/app/plugins/datasource/graphite/state/providers.ts
index 6db0021d96a..4c59e641339 100644
--- a/public/app/plugins/datasource/graphite/state/providers.ts
+++ b/public/app/plugins/datasource/graphite/state/providers.ts
@@ -96,7 +96,9 @@ async function getAltSegments(
       return altSegments;
     }
   } catch (err) {
-    handleMetricsAutoCompleteError(state, err);
+    if (err instanceof Error) {
+      handleMetricsAutoCompleteError(state, err);
+    }
   }
 
   return [];
@@ -133,7 +135,9 @@ async function getTags(state: GraphiteQueryEditorState, index: number, tagPrefix
     altTags.splice(0, 0, state.removeTagValue);
     return altTags;
   } catch (err) {
-    handleTagsAutoCompleteError(state, err);
+    if (err instanceof Error) {
+      handleTagsAutoCompleteError(state, err);
+    }
   }
 
   return [];
@@ -168,7 +172,9 @@ async function getTagsAsSegments(state: GraphiteQueryEditorState, tagPrefix: str
     });
   } catch (err) {
     tagsAsSegments = [];
-    handleTagsAutoCompleteError(state, err);
+    if (err instanceof Error) {
+      handleTagsAutoCompleteError(state, err);
+    }
   }
 
   return tagsAsSegments;
diff --git a/public/app/plugins/datasource/graphite/types.ts b/public/app/plugins/datasource/graphite/types.ts
index ce5d5436d85..23ede708119 100644
--- a/public/app/plugins/datasource/graphite/types.ts
+++ b/public/app/plugins/datasource/graphite/types.ts
@@ -41,6 +41,11 @@ export interface MetricTankMeta {
   info: MetricTankSeriesMeta[];
 }
 
+export interface GraphiteParserError {
+  message: string;
+  pos: number;
+}
+
 export type GraphiteQueryImportConfiguration = {
   loki: GraphiteToLokiQueryImportConfiguration;
 };
diff --git a/public/app/plugins/datasource/graphite/utils.ts b/public/app/plugins/datasource/graphite/utils.ts
index 0a47176ccd0..88f0a5332cd 100644
--- a/public/app/plugins/datasource/graphite/utils.ts
+++ b/public/app/plugins/datasource/graphite/utils.ts
@@ -1,5 +1,7 @@
 import { last } from 'lodash';
 
+import { GraphiteParserError } from './types';
+
 /**
  * Graphite-web before v1.6 returns HTTP 500 with full stack traces in an HTML page
  * when a query fails. It results in massive error alerts with HTML tags in the UI.
@@ -19,3 +21,7 @@ export function reduceError(error: any): any {
   }
   return error;
 }
+
+export function isGraphiteParserError(e: unknown): e is GraphiteParserError {
+  return typeof e === 'object' && e !== null && 'message' in e && 'pos' in e;
+}
diff --git a/public/app/plugins/datasource/influxdb/specs/datasource.test.ts b/public/app/plugins/datasource/influxdb/specs/datasource.test.ts
index 604e9c53a36..4c0f58ca288 100644
--- a/public/app/plugins/datasource/influxdb/specs/datasource.test.ts
+++ b/public/app/plugins/datasource/influxdb/specs/datasource.test.ts
@@ -116,7 +116,9 @@ describe('InfluxDataSource', () => {
       try {
         await lastValueFrom(ctx.ds.query(queryOptions));
       } catch (err) {
-        expect(err.message).toBe('InfluxDB Error: Query timeout');
+        if (err instanceof Error) {
+          expect(err.message).toBe('InfluxDB Error: Query timeout');
+        }
       }
     });
   });
diff --git a/public/app/plugins/datasource/jaeger/components/SearchForm.tsx b/public/app/plugins/datasource/jaeger/components/SearchForm.tsx
index 545750521ea..66a450d30bf 100644
--- a/public/app/plugins/datasource/jaeger/components/SearchForm.tsx
+++ b/public/app/plugins/datasource/jaeger/components/SearchForm.tsx
@@ -54,7 +54,9 @@ export function SearchForm({ datasource, query, onChange }: Props) {
         const filteredOptions = options.filter((item) => (item.value ? fuzzyMatch(item.value, query).found : false));
         return filteredOptions;
       } catch (error) {
-        dispatch(notifyApp(createErrorNotification('Error', error)));
+        if (error instanceof Error) {
+          dispatch(notifyApp(createErrorNotification('Error', error)));
+        }
         return [];
       } finally {
         setIsLoading((prevValue) => ({ ...prevValue, [loaderOfType]: false }));
diff --git a/public/app/plugins/datasource/loki/querybuilder/parsing.ts b/public/app/plugins/datasource/loki/querybuilder/parsing.ts
index f0fff40f33e..469dcb4ccb7 100644
--- a/public/app/plugins/datasource/loki/querybuilder/parsing.ts
+++ b/public/app/plugins/datasource/loki/querybuilder/parsing.ts
@@ -49,9 +49,11 @@ export function buildVisualQueryFromString(expr: string): Context {
   } catch (err) {
     // Not ideal to log it here, but otherwise we would lose the stack trace.
     console.error(err);
-    context.errors.push({
-      text: err.message,
-    });
+    if (err instanceof Error) {
+      context.errors.push({
+        text: err.message,
+      });
+    }
   }
 
   // If we have empty query, we want to reset errors
diff --git a/public/app/plugins/datasource/opentsdb/query_ctrl.ts b/public/app/plugins/datasource/opentsdb/query_ctrl.ts
index dc6bec377a3..7e71745f7c9 100644
--- a/public/app/plugins/datasource/opentsdb/query_ctrl.ts
+++ b/public/app/plugins/datasource/opentsdb/query_ctrl.ts
@@ -210,7 +210,9 @@ export class OpenTsQueryCtrl extends QueryCtrl {
           errs.downsampleInterval = "You must supply a downsample interval (e.g. '1m' or '1h').";
         }
       } catch (err) {
-        errs.downsampleInterval = err.message;
+        if (err instanceof Error) {
+          errs.downsampleInterval = err.message;
+        }
       }
     }
 
diff --git a/public/app/plugins/datasource/prometheus/components/PromQueryField.tsx b/public/app/plugins/datasource/prometheus/components/PromQueryField.tsx
index 113e53386e9..07e44b67135 100644
--- a/public/app/plugins/datasource/prometheus/components/PromQueryField.tsx
+++ b/public/app/plugins/datasource/prometheus/components/PromQueryField.tsx
@@ -13,7 +13,11 @@ import {
   Icon,
 } from '@grafana/ui';
 import { LocalStorageValueProvider } from 'app/core/components/LocalStorageValueProvider';
-import { CancelablePromise, makePromiseCancelable } from 'app/core/utils/CancelablePromise';
+import {
+  CancelablePromise,
+  isCancelablePromiseRejection,
+  makePromiseCancelable,
+} from 'app/core/utils/CancelablePromise';
 
 import { PrometheusDatasource } from '../datasource';
 import { roundMsToMin } from '../language_utils';
@@ -174,7 +178,9 @@ class PromQueryField extends React.PureComponent<PromQueryFieldProps, PromQueryF
       await Promise.all(remainingTasks);
       this.onUpdateLanguage();
     } catch (err) {
-      if (!err.isCanceled) {
+      if (isCancelablePromiseRejection(err) && err.isCanceled) {
+        // do nothing, promise was canceled
+      } else {
         throw err;
       }
     }
diff --git a/public/app/plugins/datasource/prometheus/datasource.tsx b/public/app/plugins/datasource/prometheus/datasource.tsx
index daf59a796f3..5c834905386 100644
--- a/public/app/plugins/datasource/prometheus/datasource.tsx
+++ b/public/app/plugins/datasource/prometheus/datasource.tsx
@@ -31,6 +31,7 @@ import {
   DataSourceWithBackend,
   BackendDataSourceResponse,
   toDataQueryResponse,
+  isFetchError,
 } from '@grafana/runtime';
 import { Badge, BadgeColor, Tooltip } from '@grafana/ui';
 import { safeStringifyValue } from 'app/core/utils/explore';
@@ -224,7 +225,7 @@ export class PrometheusDatasource
         );
       } catch (err) {
         // If status code of error is Method Not Allowed (405) and HTTP method is POST, retry with GET
-        if (this.httpMethod === 'POST' && (err.status === 405 || err.status === 400)) {
+        if (this.httpMethod === 'POST' && isFetchError(err) && (err.status === 405 || err.status === 400)) {
           console.warn(`Couldn't use configured POST HTTP method for this request. Trying to use GET method instead.`);
         } else {
           throw err;
diff --git a/public/app/plugins/datasource/prometheus/querybuilder/parsing.ts b/public/app/plugins/datasource/prometheus/querybuilder/parsing.ts
index 03b0a72c556..edf343cd234 100644
--- a/public/app/plugins/datasource/prometheus/querybuilder/parsing.ts
+++ b/public/app/plugins/datasource/prometheus/querybuilder/parsing.ts
@@ -43,9 +43,11 @@ export function buildVisualQueryFromString(expr: string): Context {
   } catch (err) {
     // Not ideal to log it here, but otherwise we would lose the stack trace.
     console.error(err);
-    context.errors.push({
-      text: err.message,
-    });
+    if (err instanceof Error) {
+      context.errors.push({
+        text: err.message,
+      });
+    }
   }
 
   // If we have empty query, we want to reset errors
diff --git a/public/app/plugins/datasource/tempo/QueryEditor/NativeSearch.tsx b/public/app/plugins/datasource/tempo/QueryEditor/NativeSearch.tsx
index 4e83d2808b5..0fdb8e983fa 100644
--- a/public/app/plugins/datasource/tempo/QueryEditor/NativeSearch.tsx
+++ b/public/app/plugins/datasource/tempo/QueryEditor/NativeSearch.tsx
@@ -4,7 +4,7 @@ import React, { useCallback, useState, useEffect, useMemo } from 'react';
 import { Node } from 'slate';
 
 import { GrafanaTheme2, isValidGoDuration, SelectableValue } from '@grafana/data';
-import { getTemplateSrv, TemplateSrv } from '@grafana/runtime';
+import { FetchError, getTemplateSrv, isFetchError, TemplateSrv } from '@grafana/runtime';
 import {
   InlineFieldRow,
   InlineField,
@@ -53,7 +53,7 @@ const NativeSearch = ({ datasource, query, onChange, onBlur, onRunQuery }: Props
   const [hasSyntaxLoaded, setHasSyntaxLoaded] = useState(false);
   const [serviceOptions, setServiceOptions] = useState<Array<SelectableValue<string>>>();
   const [spanOptions, setSpanOptions] = useState<Array<SelectableValue<string>>>();
-  const [error, setError] = useState(null);
+  const [error, setError] = useState<Error | FetchError | null>(null);
   const [inputErrors, setInputErrors] = useState<{ [key: string]: boolean }>({});
   const [isLoading, setIsLoading] = useState<{
     serviceName: boolean;
@@ -73,9 +73,9 @@ const NativeSearch = ({ datasource, query, onChange, onBlur, onRunQuery }: Props
         const filteredOptions = options.filter((item) => (item.value ? fuzzyMatch(item.value, query).found : false));
         return filteredOptions;
       } catch (error) {
-        if (error?.status === 404) {
+        if (isFetchError(error) && error?.status === 404) {
           setError(error);
-        } else {
+        } else if (error instanceof Error) {
           dispatch(notifyApp(createErrorNotification('Error', error)));
         }
         return [];
@@ -94,9 +94,9 @@ const NativeSearch = ({ datasource, query, onChange, onBlur, onRunQuery }: Props
         setSpanOptions(spans);
       } catch (error) {
         // Display message if Tempo is connected but search 404's
-        if (error?.status === 404) {
+        if (isFetchError(error) && error?.status === 404) {
           setError(error);
-        } else {
+        } else if (error instanceof Error) {
           dispatch(notifyApp(createErrorNotification('Error', error)));
         }
       }
@@ -110,7 +110,9 @@ const NativeSearch = ({ datasource, query, onChange, onBlur, onRunQuery }: Props
         await languageProvider.start();
         setHasSyntaxLoaded(true);
       } catch (error) {
-        dispatch(notifyApp(createErrorNotification('Error', error)));
+        if (error instanceof Error) {
+          dispatch(notifyApp(createErrorNotification('Error', error)));
+        }
       }
     };
     fetchTags();
diff --git a/public/app/plugins/datasource/tempo/datasource.ts b/public/app/plugins/datasource/tempo/datasource.ts
index e00edda69f2..6ec7a4a40bd 100644
--- a/public/app/plugins/datasource/tempo/datasource.ts
+++ b/public/app/plugins/datasource/tempo/datasource.ts
@@ -190,7 +190,7 @@ export class TempoDatasource extends DataSourceWithBackend<TempoQuery, TempoJson
           )
         );
       } catch (error) {
-        return of({ error: { message: error.message }, data: [] });
+        return of({ error: { message: error instanceof Error ? error.message : 'Unknown error occurred' }, data: [] });
       }
     }
 
diff --git a/public/app/plugins/datasource/testdata/datasource.ts b/public/app/plugins/datasource/testdata/datasource.ts
index a2deb9e8641..a79e258bea5 100644
--- a/public/app/plugins/datasource/testdata/datasource.ts
+++ b/public/app/plugins/datasource/testdata/datasource.ts
@@ -222,7 +222,10 @@ export class TestDataDataSource extends DataSourceWithBackend<TestDataQuery> {
       });
       return of({ data, state: LoadingState.Done }).pipe(delay(100));
     } catch (ex) {
-      return of({ data: [], error: ex }).pipe(delay(100));
+      return of({
+        data: [],
+        error: ex instanceof Error ? ex : new Error('Unkown error'),
+      }).pipe(delay(100));
     }
   }
 
diff --git a/public/app/plugins/datasource/zipkin/QueryField.tsx b/public/app/plugins/datasource/zipkin/QueryField.tsx
index ed63da354e1..68d16163fbb 100644
--- a/public/app/plugins/datasource/zipkin/QueryField.tsx
+++ b/public/app/plugins/datasource/zipkin/QueryField.tsx
@@ -131,7 +131,8 @@ export function useServices(datasource: ZipkinDatasource): AsyncState<CascaderOp
       }
       return [];
     } catch (error) {
-      dispatch(notifyApp(createErrorNotification('Failed to load services from Zipkin', error)));
+      const errorToShow = error instanceof Error ? error : 'An unknown error occurred';
+      dispatch(notifyApp(createErrorNotification('Failed to load services from Zipkin', errorToShow)));
       throw error;
     }
   }, [datasource]);
@@ -175,7 +176,8 @@ export function useLoadOptions(datasource: ZipkinDatasource) {
           });
         }
       } catch (error) {
-        dispatch(notifyApp(createErrorNotification('Failed to load spans from Zipkin', error)));
+        const errorToShow = error instanceof Error ? error : 'An unknown error occurred';
+        dispatch(notifyApp(createErrorNotification('Failed to load spans from Zipkin', errorToShow)));
         throw error;
       }
     },
@@ -216,7 +218,8 @@ export function useLoadOptions(datasource: ZipkinDatasource) {
           });
         }
       } catch (error) {
-        dispatch(notifyApp(createErrorNotification('Failed to load spans from Zipkin', error)));
+        const errorToShow = error instanceof Error ? error : 'An unknown error occurred';
+        dispatch(notifyApp(createErrorNotification('Failed to load spans from Zipkin', errorToShow)));
         throw error;
       }
     },
diff --git a/public/app/plugins/panel/canvas/editor/APIEditor.tsx b/public/app/plugins/panel/canvas/editor/APIEditor.tsx
index 370b363b560..01bad2140d1 100644
--- a/public/app/plugins/panel/canvas/editor/APIEditor.tsx
+++ b/public/app/plugins/panel/canvas/editor/APIEditor.tsx
@@ -68,7 +68,11 @@ export const APIEditor: FC<StandardEditorProps<APIEditorConfig, any, any>> = (pr
       const json = JSON.parse(data);
       return <JSONFormatter json={json} />;
     } catch (error) {
-      return `Invalid JSON provided: ${error.message}`;
+      if (error instanceof Error) {
+        return `Invalid JSON provided: ${error.message}`;
+      } else {
+        return 'Invalid JSON provided';
+      }
     }
   };
 
diff --git a/public/app/plugins/panel/graph/graph.ts b/public/app/plugins/panel/graph/graph.ts
index 13467292b78..71f95318fa3 100644
--- a/public/app/plugins/panel/graph/graph.ts
+++ b/public/app/plugins/panel/graph/graph.ts
@@ -571,7 +571,7 @@ class GraphElement {
       }
     } catch (e) {
       console.error('flotcharts error', e);
-      this.ctrl.error = e.message || 'Render Error';
+      this.ctrl.error = e instanceof Error ? e.message : 'Render Error';
       this.ctrl.renderError = true;
     }
 
diff --git a/public/app/plugins/panel/heatmap/heatmap_data_converter.ts b/public/app/plugins/panel/heatmap/heatmap_data_converter.ts
index 95183a6a7f8..d979e204d1f 100644
--- a/public/app/plugins/panel/heatmap/heatmap_data_converter.ts
+++ b/public/app/plugins/panel/heatmap/heatmap_data_converter.ts
@@ -61,7 +61,7 @@ function sortSeriesByLabel(s1: { label: string }, s2: { label: string }) {
     label1 = parseHistogramLabel(s1.label);
     label2 = parseHistogramLabel(s2.label);
   } catch (err) {
-    console.error(err.message || err);
+    console.error(err instanceof Error ? err.message : err);
     return 0;
   }
 
diff --git a/public/app/plugins/panel/heatmap/rendering.ts b/public/app/plugins/panel/heatmap/rendering.ts
index 906224b24e2..e92ffdf00e4 100644
--- a/public/app/plugins/panel/heatmap/rendering.ts
+++ b/public/app/plugins/panel/heatmap/rendering.ts
@@ -449,7 +449,7 @@ export class HeatmapRenderer {
           return formattedValueToString(v);
         }
       } catch (err) {
-        console.error(err.message || err);
+        console.error(err instanceof Error ? err.message : err);
       }
       return value;
     };
diff --git a/public/app/plugins/panel/xychart/scatter.ts b/public/app/plugins/panel/xychart/scatter.ts
index 022e9db6707..646d7b42f32 100644
--- a/public/app/plugins/panel/xychart/scatter.ts
+++ b/public/app/plugins/panel/xychart/scatter.ts
@@ -51,8 +51,9 @@ export function prepScatter(
     builder = prepConfig(getData, series, theme, ttip);
   } catch (e) {
     console.log('prepScatter ERROR', e);
+    const errorMessage = e instanceof Error ? e.message : 'Unknown error in prepScatter';
     return {
-      error: e.message,
+      error: errorMessage,
       series: [],
     };
   }
diff --git a/public/test/matchers/toEmitValues.ts b/public/test/matchers/toEmitValues.ts
index e8bf9e80470..80e96d7e32c 100644
--- a/public/test/matchers/toEmitValues.ts
+++ b/public/test/matchers/toEmitValues.ts
@@ -50,9 +50,10 @@ function tryExpectations(received: any[], expected: any[]): jest.CustomMatcherRe
       message: () => passMessage(received, expected),
     };
   } catch (err) {
+    const message = err instanceof Error ? err.message : 'An unknown error occurred';
     return {
       pass: false,
-      message: () => err,
+      message: () => message,
     };
   }
 }
diff --git a/tsconfig.json b/tsconfig.json
index db195a464c3..5849b509339 100644
--- a/tsconfig.json
+++ b/tsconfig.json
@@ -7,7 +7,7 @@
     "allowJs": true,
     "strict": true,
     "resolveJsonModule": true,
-    "useUnknownInCatchVariables": false,
+    "useUnknownInCatchVariables": true,
     "incremental": true,
     "tsBuildInfoFile": "./tsconfig.tsbuildinfo"
   },