diff --git a/packages/grafana-ui/src/components/uPlot/plugins/TooltipPlugin.tsx b/packages/grafana-ui/src/components/uPlot/plugins/TooltipPlugin.tsx
index 1408d19018e..ce4c8ce6736 100644
--- a/packages/grafana-ui/src/components/uPlot/plugins/TooltipPlugin.tsx
+++ b/packages/grafana-ui/src/components/uPlot/plugins/TooltipPlugin.tsx
@@ -56,6 +56,7 @@ export const TooltipPlugin: React.FC<TooltipPluginProps> = ({
     }
 
     return () => {
+      setCoords(null);
       if (plotCtx && plotCtx.plot) {
         plotCtx.plot.over.removeEventListener('mouseleave', plotMouseLeave);
       }