diff --git a/public/app/plugins/datasource/tempo/SearchTraceQLEditor/utils.ts b/public/app/plugins/datasource/tempo/SearchTraceQLEditor/utils.ts
index d96dce6740e..8e3444bcc85 100644
--- a/public/app/plugins/datasource/tempo/SearchTraceQLEditor/utils.ts
+++ b/public/app/plugins/datasource/tempo/SearchTraceQLEditor/utils.ts
@@ -5,6 +5,7 @@ import { getTemplateSrv } from '@grafana/runtime';
 import { VariableFormatID } from '@grafana/schema';
 
 import { TraceqlFilter, TraceqlSearchScope } from '../dataquery.gen';
+import { getEscapedSpanNames } from '../datasource';
 import TempoLanguageProvider from '../language_provider';
 import { Scope } from '../types';
 
@@ -28,14 +29,20 @@ export const interpolateFilters = (filters: TraceqlFilter[], scopedVars?: Scoped
   return interpolatedFilters;
 };
 
+const isRegExpOperator = (operator: string) => operator === '=~' || operator === '!~';
+
+const escapeValues = (values: string[]) => getEscapedSpanNames(values);
+
 export const valueHelper = (f: TraceqlFilter) => {
-  if (Array.isArray(f.value) && f.value.length > 1) {
-    return `"${f.value.join('|')}"`;
+  const value = Array.isArray(f.value) && isRegExpOperator(f.operator!) ? escapeValues(f.value) : f.value;
+
+  if (Array.isArray(value) && value.length > 1) {
+    return `"${value.join('|')}"`;
   }
   if (f.valueType === 'string') {
-    return `"${f.value}"`;
+    return `"${value}"`;
   }
-  return f.value;
+  return value;
 };
 
 export const scopeHelper = (f: TraceqlFilter, lp: TempoLanguageProvider) => {
diff --git a/public/app/plugins/datasource/tempo/language_provider.test.ts b/public/app/plugins/datasource/tempo/language_provider.test.ts
index 2d6d71ec526..9bd44f33bed 100644
--- a/public/app/plugins/datasource/tempo/language_provider.test.ts
+++ b/public/app/plugins/datasource/tempo/language_provider.test.ts
@@ -173,6 +173,20 @@ describe('Language_provider', () => {
         lp.generateQueryFromFilters([{ id: 'foo', tag: 'footag', value: '1234', operator: '>', valueType: 'integer' }])
       ).toBe('{.footag>1234}');
     });
+    it.each([['=~'], ['!~']])('a field with a regexp operator (%s)', (operator) => {
+      expect(
+        lp.generateQueryFromFilters([
+          {
+            id: 'span-name',
+            tag: 'name',
+            operator,
+            scope: TraceqlSearchScope.Span,
+            value: ['api/v2/variants/by-upc/(?P<upc>[\\s\\S]*)/$'],
+            valueType: 'string',
+          },
+        ])
+      ).toBe(`{name${operator}"api/v2/variants/by-upc/\\\\(\\\\?P<upc>\\\\[\\\\\\\\s\\\\\\\\S\\\\]\\\\*\\\\)/\\\\$"}`);
+    });
     it('two fields with everything filled in', () => {
       expect(
         lp.generateQueryFromFilters([