diff --git a/CMakeLists.txt b/CMakeLists.txt
index b796977515b..6019fe63d93 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -63,12 +63,6 @@ function(build_ngraph)
         ngraph_set(NGRAPH_PDPD_FRONTEND_ENABLE OFF)
     endif()
 
-    if(ENABLE_PYTHON)
-        ngraph_set(NGRAPH_PYTHON_BUILD_ENABLE ON)
-    else()
-        ngraph_set(NGRAPH_PYTHON_BUILD_ENABLE OFF)
-    endif()
-
     if(CMAKE_CXX_COMPILER_ID MATCHES "^(Apple)?Clang$")
         ie_add_compiler_flags(-Wno-error=uninitialized -Wno-error=literal-conversion)
     elseif(UNIX)
diff --git a/inference-engine/ie_bridges/python/CMakeLists.txt b/inference-engine/ie_bridges/python/CMakeLists.txt
index 89cdb5cc17f..7b93a4291a2 100644
--- a/inference-engine/ie_bridges/python/CMakeLists.txt
+++ b/inference-engine/ie_bridges/python/CMakeLists.txt
@@ -68,7 +68,7 @@ if(ENABLE_WHEEL)
     add_subdirectory(wheel)
 endif()
 
-if (NGRAPH_PYTHON_BUILD_ENABLE)
+if(TARGET _pyngraph)
     add_dependencies(ie_api _pyngraph)
 endif()
 
diff --git a/inference-engine/ie_bridges/python/README.md b/inference-engine/ie_bridges/python/README.md
index 0b50a0e2a6a..b40a6ded9b0 100644
--- a/inference-engine/ie_bridges/python/README.md
+++ b/inference-engine/ie_bridges/python/README.md
@@ -61,11 +61,6 @@ sudo apt install patchelf
 -DENABLE_PYTHON=ON
 -DENABLE_WHEEL=ON
 ```
-If you need to include other components to the package you need to enable them too.
-For example, to include ngraph python API:
-```shellscript
--NGRAPH_PYTHON_BUILD_ENABLE=ON
-```
 
 ## Running sample
 
diff --git a/model-optimizer/CMakeLists.txt b/model-optimizer/CMakeLists.txt
index 60860d7a7aa..19056e1b60c 100644
--- a/model-optimizer/CMakeLists.txt
+++ b/model-optimizer/CMakeLists.txt
@@ -1,10 +1,8 @@
 # Copyright (C) 2018-2021 Intel Corporation
 # SPDX-License-Identifier: Apache-2.0
 
-if (NOT NGRAPH_PYTHON_BUILD_ENABLE)
-    message(WARNING "Please enable nGraph Python API (_pyngraph) target to enable Model Optimizer target")
-elseif(NOT ENABLE_PYTHON)
-    message(WARNING "Please enable IE Python API (ie_api and offline_transformations_api) targets to enable Model Optimizer target")
+if(NOT ENABLE_PYTHON)
+    message(WARNING "Please enable IE & nGraph Python API (ie_api and offline_transformations_api) targets to enable Model Optimizer target")
 else()
     add_custom_target(model_optimizer DEPENDS ie_api offline_transformations_api inference_engine_ir_reader)
     if(ENABLE_TESTS)
diff --git a/ngraph/CMakeLists.txt b/ngraph/CMakeLists.txt
index 27bba57bc37..20fe4a9af12 100644
--- a/ngraph/CMakeLists.txt
+++ b/ngraph/CMakeLists.txt
@@ -23,7 +23,6 @@ option(NGRAPH_DEBUG_ENABLE "Enable output for NGRAPH_DEBUG statements" OFF)
 option(NGRAPH_ONNX_IMPORT_ENABLE "Enable ONNX importer" OFF)
 option(NGRAPH_ONNX_EDITOR_ENABLE "Enable ONNX Editor" OFF)
 option(NGRAPH_PDPD_FRONTEND_ENABLE "Enable PaddlePaddle FrontEnd" OFF)
-option(NGRAPH_PYTHON_BUILD_ENABLE "Enable build nGraph python package wheel" OFF)
 option(NGRAPH_USE_PROTOBUF_LITE "Compiles and links with protobuf-lite" OFF)
 
 if (NGRAPH_ONNX_IMPORT_ENABLE OR NGRAPH_PDPD_FRONTEND_ENABLE)
@@ -37,7 +36,6 @@ message(STATUS "NGRAPH_DEBUG_ENABLE:                  ${NGRAPH_DEBUG_ENABLE}")
 message(STATUS "NGRAPH_ONNX_IMPORT_ENABLE:            ${NGRAPH_ONNX_IMPORT_ENABLE}")
 message(STATUS "NGRAPH_ONNX_EDITOR_ENABLE:            ${NGRAPH_ONNX_EDITOR_ENABLE}")
 message(STATUS "NGRAPH_PDPD_FRONTEND_ENABLE:          ${NGRAPH_PDPD_FRONTEND_ENABLE}")
-message(STATUS "NGRAPH_PYTHON_BUILD_ENABLE:           ${NGRAPH_PYTHON_BUILD_ENABLE}")
 message(STATUS "NGRAPH_USE_PROTOBUF_LITE:             ${NGRAPH_USE_PROTOBUF_LITE}")
 message(STATUS "NGRAPH_UNIT_TEST_ENABLE:              ${NGRAPH_UNIT_TEST_ENABLE}")
 message(STATUS "NGRAPH_UNIT_TEST_BACKENDS_ENABLE:     ${NGRAPH_UNIT_TEST_BACKENDS_ENABLE}")
@@ -202,6 +200,6 @@ add_subdirectory(frontend)
 
 add_subdirectory(test)
 
-if (NGRAPH_PYTHON_BUILD_ENABLE)
+if (ENABLE_PYTHON)
     add_subdirectory(python)
 endif()
diff --git a/ngraph/python/BUILDING.md b/ngraph/python/BUILDING.md
index 5d4d9c72892..18e395fc9d8 100644
--- a/ngraph/python/BUILDING.md
+++ b/ngraph/python/BUILDING.md
@@ -48,7 +48,6 @@ set the mentioned flags to `ON`. Note the `CMAKE_INSTALL_PREFIX`, which defaults
         -DENABLE_OPENCV=OFF \
         -DENABLE_VPU=OFF \
         -DENABLE_PYTHON=ON \
-        -DNGRAPH_PYTHON_BUILD_ENABLE=ON \
         -DNGRAPH_ONNX_IMPORT_ENABLE=ON \
         -DCMAKE_INSTALL_PREFIX="${OPENVINO_BASEDIR}/openvino_dist"
     
@@ -111,7 +110,6 @@ cmake .. ^
     -DENABLE_CLDNN=OFF ^
     -DENABLE_OPENCV=OFF ^
     -DENABLE_VPU=OFF ^
-    -DNGRAPH_PYTHON_BUILD_ENABLE=ON ^
     -DNGRAPH_ONNX_IMPORT_ENABLE=ON ^
     -DENABLE_PYTHON=ON ^
     -DCMAKE_CXX_COMPILER="C:\Program Files (x86)\Microsoft Visual Studio\2019\Community\VC\Tools\MSVC\14.27.29110\bin\Hostx64\x64"
diff --git a/ngraph/python/setup.py b/ngraph/python/setup.py
index e90cc66d6d1..059ccd81acb 100644
--- a/ngraph/python/setup.py
+++ b/ngraph/python/setup.py
@@ -155,7 +155,7 @@ class BuildCMakeExt(build_ext):
         ext_args = self.cmake_args.split() if self.cmake_args else []
         self.spawn(["cmake", "-H" + root_dir, "-B" + self.build_temp,
                     "-DCMAKE_BUILD_TYPE={}".format(self.config),
-                    "-DNGRAPH_PYTHON_BUILD_ENABLE=ON",
+                    "-DENABLE_PYTHON=ON",
                     "-DNGRAPH_ONNX_IMPORT_ENABLE=ON"] + ext_args)
 
         self.announce("Building binaries", level=3)