diff --git a/inference-engine/thirdparty/clDNN/src/include/layout_optimizer.h b/inference-engine/thirdparty/clDNN/src/include/layout_optimizer.h
index 891de708c91..c55d4bb9833 100644
--- a/inference-engine/thirdparty/clDNN/src/include/layout_optimizer.h
+++ b/inference-engine/thirdparty/clDNN/src/include/layout_optimizer.h
@@ -29,6 +29,7 @@
 #include "binary_convolution_inst.h"
 #include "lstm_gemm_inst.h"
 #include "generic_layer.hpp"
+#include "region_yolo_inst.h"
 
 #include "kernel_selector_common.h"
 #include "kernel_selector_helper.h"
diff --git a/inference-engine/thirdparty/clDNN/src/layout_optimizer.cpp b/inference-engine/thirdparty/clDNN/src/layout_optimizer.cpp
index a4b37f59b9b..23e6d51e465 100644
--- a/inference-engine/thirdparty/clDNN/src/layout_optimizer.cpp
+++ b/inference-engine/thirdparty/clDNN/src/layout_optimizer.cpp
@@ -861,6 +861,10 @@ format layout_optimizer::get_preferred_format(program_node& node) {
         if (input_layout.format.dimension() == 5 &&
             (input_layout.data_type == data_types::f32 || input_layout.data_type == data_types::f16 ))
             expected = format::bfzyx;
+    } else if (node.is_type<region_yolo>()) {
+        if (_optimization_attributes.b_fs_yx_fsv16_network) {
+            expected = format::bfyx;
+        }
     }
 
     return expected;
diff --git a/inference-engine/thirdparty/clDNN/src/program.cpp b/inference-engine/thirdparty/clDNN/src/program.cpp
index 599038afbe3..ed050e7a7d3 100644
--- a/inference-engine/thirdparty/clDNN/src/program.cpp
+++ b/inference-engine/thirdparty/clDNN/src/program.cpp
@@ -62,6 +62,7 @@
 #include "mvn_inst.h"
 #include "gemm_inst.h"
 #include "reduce_inst.h"
+#include "region_yolo_inst.h"
 #include "strided_slice_inst.h"
 #include "to_string_utils.h"
 #include "gpu/memory_gpu.h"
@@ -1219,7 +1220,8 @@ void program_impl::set_layout_optimizer_attributes(layout_optimizer& lo) {
             prim.type() != cldnn::arg_max_min::type_id() &&
             prim.type() != cldnn::mutable_data::type_id() &&
             prim.type() != cldnn::reduce::type_id() &&
-            prim.type() != cldnn::strided_slice::type_id())
+            prim.type() != cldnn::strided_slice::type_id() &&
+            prim.type() != cldnn::region_yolo::type_id())
             can_use_fsv16 = false;
 
         if (prim.type() == cldnn::quantize::type_id() &&