diff --git a/.ci/azure/linux_arm64.yml b/.ci/azure/linux_arm64.yml
index 6f3557e3a61..da966d97e5e 100644
--- a/.ci/azure/linux_arm64.yml
+++ b/.ci/azure/linux_arm64.yml
@@ -61,6 +61,7 @@ jobs:
     BUILD_OPENVINO: $(WORK_DIR)/build
     BUILD_OPENVINO_PYTHON: $(WORK_DIR)/build_python
     BUILD_OPEN_MODEL_ZOO: $(WORK_DIR)/build_open_model_zoo
+    CROSSENV_DIR: $(WORK_DIR)/cross_env
     INSTALL_OPENVINO: $(WORK_DIR)/install_openvino
     INSTALL_PYTHON: $(INSTALL_OPENVINO)/extras/python
     INSTALL_ONETBB: $(WORK_DIR)/build/extras/oneTBB
@@ -155,6 +156,16 @@ jobs:
     workingDirectory: $(BUILD_OPENVINO)
     displayName: 'Install dependencies'
 
+  - script: |
+      set -e
+      /usr/local/bin/$(PYTHON_EXEC) -m pip install -U pip
+      /usr/local/bin/$(PYTHON_EXEC) -m pip install crossenv
+      /usr/local/bin/$(PYTHON_EXEC) -m crossenv $(INSTALL_PYTHON)/bin/$(PYTHON_EXEC) $(CROSSENV_DIR)
+      source $(CROSSENV_DIR)/bin/activate
+      build-pip3 install -U pip install -r $(OPENVINO_REPO_DIR)/src/bindings/python/wheel/requirements-dev.txt
+      cross-pip3 install -U pip install -r $(OPENVINO_REPO_DIR)/src/bindings/python/wheel/requirements-dev.txt
+    workingDirectory: $(BUILD_OPENVINO)
+    displayName: 'Create crossenv'
 
   - task: CMake@1
     inputs:
@@ -163,20 +174,16 @@ jobs:
         -DCMAKE_VERBOSE_MAKEFILE=ON
         -DCMAKE_COMPILE_WARNING_AS_ERROR=OFF
         -DOpenCV_DIR=$(INSTALL_OPENCV)/cmake
-        -DPYTHON_INCLUDE_DIRS=$(INSTALL_PYTHON)/include/python3.10
-        -DPYTHON_LIBRARY=$(INSTALL_PYTHON)/lib/libpython3.10.so
-        -DENABLE_PYTHON=ON
-        -DPYTHON_MODULE_EXTENSION=".cpython-310-x86_64-linux-gnu.so"
+        -DENABLE_PYTHON=OFF
         -DENABLE_TESTS=ON
         -DENABLE_DATA=OFF
-        -DCMAKE_EXE_LINKER_FLAGS=-Wl,-rpath-link,$(INSTALL_OPENCV)/lib
         -DENABLE_LTO=ON
         -DCMAKE_TOOLCHAIN_FILE=$(OPENVINO_REPO_DIR)/cmake/arm64.toolchain.cmake
         -DCMAKE_BUILD_TYPE=$(BUILD_TYPE)
         -DENABLE_INTEL_MYRIAD=OFF
         -DTHREADING=TBB
         -DTBB_DIR=$(INSTALL_ONETBB)/lib/cmake/TBB
-        -DCMAKE_VERBOSE_MAKEFILE:BOOL=ON
+        -DCMAKE_VERBOSE_MAKEFILE=ON
         -DOPENVINO_EXTRA_MODULES=$(OPENVINO_CONTRIB_REPO_DIR)/modules/arm_plugin
         -DCMAKE_CXX_COMPILER_LAUNCHER=ccache
         -DCMAKE_C_COMPILER_LAUNCHER=ccache
@@ -202,32 +209,18 @@ jobs:
     workingDirectory: $(BUILD_OPENVINO)
     displayName: 'Install OpenVINO ARM plugin'
 
-  - task: CMake@1
-    inputs:
-      cmakeArgs: >
-        -GNinja
-        -DOpenVINODeveloperPackage_DIR=$(BUILD_OPENVINO)
-        -DENABLE_PYTHON=ON
-        -DTHREADING=TBB
-        -DPYTHON_EXECUTABLE=$(INSTALL_PYTHON)/bin/python3.10
-        -DPYTHON_INCLUDE_DIRS=$(INSTALL_PYTHON)/include/python3.10
-        -DPYTHON_LIBRARIES=$(INSTALL_PYTHON)/lib
-        -DPYTHON3_NUMPY_INCLUDE_DIRS=/usr/local/lib/python3.10/site-packages/numpy/core/include
-        -DPYTHON_MODULE_EXTENSION=".so"
-        -DPYBIND11_FINDPYTHON=OFF
-        -DPYBIND11_NOPYTHON=OFF
-        -DPYTHONLIBS_FOUND=TRUE
-        -DCMAKE_BUILD_TYPE=$(BUILD_TYPE)
-        -DENABLE_DATA=OFF
-        -DCMAKE_EXE_LINKER_FLAGS=-Wl,-rpath-link,$(INSTALL_OPENCV)/lib
-        -DCMAKE_TOOLCHAIN_FILE=$(OPENVINO_REPO_DIR)/cmake/arm64.toolchain.cmake
-        -DCMAKE_CXX_COMPILER_LAUNCHER=ccache
-        -DCMAKE_C_COMPILER_LAUNCHER=ccache
-        -DCMAKE_CXX_LINKER_LAUNCHER=ccache
-        -DCMAKE_C_LINKER_LAUNCHER=ccache
-        -DCMAKE_INSTALL_PREFIX=$(INSTALL_OPENVINO)
-        $(OPENVINO_REPO_DIR)/src/bindings/python
-      workingDirectory: $(BUILD_OPENVINO_PYTHON)
+  - script: |
+      source $(CROSSENV_DIR)/bin/activate
+      cmake \
+        -GNinja \
+        -DENABLE_PYTHON=ON \
+        -DENABLE_WHEEL=ON \
+        -DCMAKE_TOOLCHAIN_FILE=$(OPENVINO_REPO_DIR)/cmake/arm64.toolchain.cmake \
+        -DOpenVINODeveloperPackage_DIR=$(BUILD_OPENVINO) \
+        -DCMAKE_INSTALL_PREFIX=$(INSTALL_OPENVINO) \
+        -S $(OPENVINO_REPO_DIR)/src/bindings/python \
+        -B $(BUILD_OPENVINO_PYTHON)
+      deactivate
     displayName: 'CMake OpenVINO python binding'
 
   - script: |
@@ -250,15 +243,15 @@ jobs:
         -GNinja
         -DCMAKE_BUILD_TYPE=$(BUILD_TYPE)
         -DENABLE_PYTHON=ON
-        -DPYTHON_EXECUTABLE=/usr/local/bin/python3.10
-        -DPYTHON_INCLUDE_DIR=$(INSTALL_PYTHON)/include/python3.10
+        -DPYTHON_EXECUTABLE=/usr/local/bin/$(PYTHON_EXEC)
+        -DPYTHON_INCLUDE_DIR=$(INSTALL_PYTHON)/include/$(PYTHON_EXEC)
         -DPYTHON_LIBRARY=$(INSTALL_PYTHON)/lib
         -DCMAKE_TOOLCHAIN_FILE=$(OPENVINO_REPO_DIR)/cmake/arm64.toolchain.cmake
         -DOpenVINO_DIR=$(BUILD_OPENVINO)
         -DOpenCV_DIR=$(INSTALL_OPENCV)/cmake
         -DCMAKE_INSTALL_PREFIX=$(INSTALL_OPEN_MODEL_ZOO)
-        $(OPENVINO_REPO_DIR)/thirdparty/open_model_zoo/demos
-      workingDirectory: $(BUILD_OPEN_MODEL_ZOO)
+        -S $(OPENVINO_REPO_DIR)/thirdparty/open_model_zoo/demos
+        -B $(BUILD_OPEN_MODEL_ZOO)
     displayName: 'CMake Open Model Zoo demos'
 
   - script: ninja
diff --git a/thirdparty/protobuf/CMakeLists.txt b/thirdparty/protobuf/CMakeLists.txt
index fb9f310d1bf..ac0fed13184 100644
--- a/thirdparty/protobuf/CMakeLists.txt
+++ b/thirdparty/protobuf/CMakeLists.txt
@@ -84,7 +84,9 @@ if(NOT protobuf_BUILD_PROTOC_BINARIES)
                     CONFIGURE_FLAGS CFLAGS CXXFLAGS LDFLAGS CPPFLAGS KCFLAGS OECORE_DISTRO_VERSION
                     OECORE_SDK_VERSION ARCH CROSS_COMPILE OE_CMAKE_TOOLCHAIN_FILE OPENSSL_CONF
                     OE_CMAKE_FIND_LIBRARY_CUSTOM_LIB_SUFFIX PKG_CONFIG_SYSROOT_DIR PKG_CONFIG_PATH)
-            list(APPEND cmake_env --unset=${var})
+            if(DEFINED ENV{${var}})
+                list(APPEND cmake_env --unset=${var})
+            endif()
         endforeach()
 
         # filter out PATH from yocto locations
@@ -103,7 +105,10 @@ if(NOT protobuf_BUILD_PROTOC_BINARIES)
             NO_DEFAULT_PATH)
     else()
         set(HOST_CMAKE_COMMAND "${CMAKE_COMMAND}")
-        # if env has CMAKE_TOOLCHAIN_FILE, we need to skip it
+    endif()
+
+    # if env has CMAKE_TOOLCHAIN_FILE, we need to skip it
+    if(DEFINED ENV{CMAKE_TOOLCHAIN_FILE})
         list(APPEND cmake_env --unset=CMAKE_TOOLCHAIN_FILE)
     endif()