diff --git a/Make.bat b/Make.bat
index 8dd44a5c3..e916ba037 100644
--- a/Make.bat
+++ b/Make.bat
@@ -181,11 +181,6 @@ REM Main build sequence Ends
     ECHO Creating virtual environment...
     IF NOT EXIST "%PGBUILDPATH%"  MKDIR "%PGBUILDPATH%"
     
-    REM If we're using VC++, and this is Python 3.6+, we need a hack for PyCrypto
-    IF "%MAKE%" == "nmake" (
-        IF %PYTHON_VERSION% GEQ 36 SET CL=-FI"%VCINSTALLDIR%\INCLUDE\stdint.h"
-    )
-
     CD "%PGBUILDPATH%"
     "%PYTHON_HOME%\Scripts\virtualenv.exe" "%VIRTUALENV%"
 
@@ -255,12 +250,6 @@ REM Main build sequence Ends
     ECHO Removing Sphinx
     CALL pip uninstall -y sphinx Pygments alabaster colorama docutils imagesize requests snowballstemmer
 
-    IF %PYTHON_MAJOR% == 3 (
-        ECHO Fixing PyCrypto module for Python 3...
-        CALL "%PYTHON_HOME%\python" "%WD%\pkg\win32\replace.py" "-i" "%PGBUILDPATH%\%VIRTUALENV%\Lib\site-packages\Crypto\Random\OSRNG\nt.py" "-o" "%PGBUILDPATH%\%VIRTUALENV%\Lib\site-packages\Crypto\Random\OSRNG\nt.py.new" "-s" "import winrandom" -r "from . import winrandom"
-        MOVE /Y "%PGBUILDPATH%\%VIRTUALENV%\Lib\site-packages\Crypto\Random\OSRNG\nt.py.new" "%PGBUILDPATH%\%VIRTUALENV%\Lib\site-packages\Crypto\Random\OSRNG\nt.py"
-    )
-
     ECHO Assembling runtime environment...
     CD "%WD%\runtime"
 
diff --git a/docs/en_US/release_notes_4_2.rst b/docs/en_US/release_notes_4_2.rst
index adb4576ad..ff51e420c 100644
--- a/docs/en_US/release_notes_4_2.rst
+++ b/docs/en_US/release_notes_4_2.rst
@@ -14,6 +14,7 @@ Features
 Bug fixes
 *********
 
+| `Bug #3272 <https://redmine.postgresql.org/issues/3272>`_ - Replace the PyCrypto module with the cryptography module.
 | `Bug #3453 <https://redmine.postgresql.org/issues/3453>`_ - Fixed SQL for foreign table options.
 | `Bug #3475 <https://redmine.postgresql.org/issues/3475>`_ - Fixed execution time to show Hours part for long running queries in Query Tool.
 | `Bug #3608 <https://redmine.postgresql.org/issues/3608>`_ - Messages tab of query tool should be clear on subsequent execution of table/view using View/Edit Data.
diff --git a/requirements.txt b/requirements.txt
index e4232191f..0140ab4da 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -18,7 +18,6 @@ html5lib==1.0.1
 linecache2==1.0.0
 passlib==1.7.1
 pbr==3.1.1
-pycrypto>=2.6.1
 pyrsistent==0.14.2
 python-mimeparse==1.6.0
 pytz==2018.3
diff --git a/web/pgadmin/utils/crypto.py b/web/pgadmin/utils/crypto.py
index 2538c71b6..3dc218951 100644
--- a/web/pgadmin/utils/crypto.py
+++ b/web/pgadmin/utils/crypto.py
@@ -9,13 +9,21 @@
 
 """This File Provides Cryptography."""
 
+from __future__ import division
+
 import base64
 import hashlib
+import os
 
-from Crypto import Random
-from Crypto.Cipher import AES
+import six
+
+from cryptography.hazmat.backends import default_backend
+from cryptography.hazmat.primitives.ciphers import Cipher
+from cryptography.hazmat.primitives.ciphers.algorithms import AES
+from cryptography.hazmat.primitives.ciphers.modes import CFB8
 
 padding_string = b'}'
+iv_size = AES.block_size // 8
 
 
 def encrypt(plaintext, key):
@@ -27,15 +35,17 @@ def encrypt(plaintext, key):
         key       -- Key for encryption.
     """
 
-    iv = Random.new().read(AES.block_size)
-    cipher = AES.new(pad(key), AES.MODE_CFB, iv)
+    iv = os.urandom(iv_size)
+    cipher = Cipher(AES(pad(key)), CFB8(iv), default_backend())
+    encryptor = cipher.encryptor()
+
     # If user has entered non ascii password (Python2)
     # we have to encode it first
-    if hasattr(str, 'decode'):
-        plaintext = plaintext.encode('utf-8')
-    encrypted = base64.b64encode(iv + cipher.encrypt(plaintext))
+    if isinstance(plaintext, six.text_type):
+        plaintext = plaintext.encode()
 
-    return encrypted
+    return base64.b64encode(iv + encryptor.update(plaintext) +
+                            encryptor.finalize())
 
 
 def decrypt(ciphertext, key):
@@ -47,36 +57,29 @@ def decrypt(ciphertext, key):
         key        -- key to decrypt the encrypted string.
     """
 
-    global padding_string
-
     ciphertext = base64.b64decode(ciphertext)
-    iv = ciphertext[:AES.block_size]
-    cipher = AES.new(pad(key), AES.MODE_CFB, iv)
-    decrypted = cipher.decrypt(ciphertext[AES.block_size:])
+    iv = ciphertext[:iv_size]
 
-    return decrypted
+    cipher = Cipher(AES(pad(key)), CFB8(iv), default_backend())
+    decryptor = cipher.decryptor()
+    return decryptor.update(ciphertext[iv_size:]) + decryptor.finalize()
 
 
 def pad(key):
     """Add padding to the key."""
 
-    global padding_string
-    str_len = len(key)
+    if isinstance(key, six.text_type):
+        key = key.encode()
 
     # Key must be maximum 32 bytes long, so take first 32 bytes
-    if str_len > 32:
-        return key[:32]
+    key = key[:32]
 
-    # If key size id 16, 24 or 32 bytes then padding not require
-    if str_len == 16 or str_len == 24 or str_len == 32:
+    # If key size is 16, 24 or 32 bytes then padding is not required
+    if len(key) in (16, 24, 32):
         return key
 
-    # Convert bytes to string (python3)
-    if not hasattr(str, 'decode'):
-        padding_string = padding_string.decode()
-
     # Add padding to make key 32 bytes long
-    return key + ((32 - str_len % 32) * padding_string)
+    return key.ljust(32, padding_string)
 
 
 def pqencryptpassword(password, user):