diff --git a/docs/en_US/release_notes_5_1.rst b/docs/en_US/release_notes_5_1.rst
index 1db854f83..af2810388 100644
--- a/docs/en_US/release_notes_5_1.rst
+++ b/docs/en_US/release_notes_5_1.rst
@@ -43,6 +43,7 @@ Bug fixes
 | `Issue #6253 <https://redmine.postgresql.org/issues/6253>`_ -  Fixed an issue where the user is unable to create a subscription if the host/IP address for connection is 127.0.0.1.
 | `Issue #6259 <https://redmine.postgresql.org/issues/6259>`_ -  Ensure that proper error message should be shown on the properties and statistics tab in case of insufficient privileges for a subscription.
 | `Issue #6260 <https://redmine.postgresql.org/issues/6260>`_ -  Fixed an issue where the 'Create Slot' option is disabled in case of the same IP/host provided but the port is different.
+| `Issue #6269 <https://redmine.postgresql.org/issues/6269>`_ -  Ensure the Python interpreter used by the runtime ignores user site-packages.
 | `Issue #6272 <https://redmine.postgresql.org/issues/6272>`_ -  Fixed an issue where the user is not able to change the connection in Query Tool when any SQL file is opened.
 | `Issue #6279 <https://redmine.postgresql.org/issues/6279>`_ -  Ensure that the venv activation scripts have the correct path in them on Linux.
 | `Issue #6281 <https://redmine.postgresql.org/issues/6281>`_ -  Fixed an issue where schema diff showing wrong SQL when comparing triggers with different when clause.
diff --git a/runtime/src/js/pgadmin.js b/runtime/src/js/pgadmin.js
index 38fb8dbc2..3a441a0fa 100644
--- a/runtime/src/js/pgadmin.js
+++ b/runtime/src/js/pgadmin.js
@@ -69,7 +69,7 @@ function startDesktopMode() {
   // Write Python Path, pgAdmin file path and command in log file.
   misc.writeServerLog('pgAdmin Runtime Environment');
   misc.writeServerLog('--------------------------------------------------------');
-  let command = path.resolve(pythonPath) + ' ' + path.resolve(pgadminFile);
+  let command = path.resolve(pythonPath) + ' -s ' + path.resolve(pgadminFile);
   misc.writeServerLog('Python Path: "' + path.resolve(pythonPath) + '"');
   misc.writeServerLog('Runtime Config File: "' + path.resolve(misc.getRunTimeConfigFile()) + '"');
   misc.writeServerLog('pgAdmin Config File: "' + path.resolve(configFile) + '"');
@@ -82,7 +82,7 @@ function startDesktopMode() {
   misc.writeServerLog('--------------------------------------------------------\n');
 
   // Spawn the process to start pgAdmin4 server.
-  pgadminServerProcess = spawn(pythonPath, [pgadminFile]);
+  pgadminServerProcess = spawn(path.resolve(pythonPath), ['-s', path.resolve(pgadminFile)]);
   pgadminServerProcess.on('error', function(err) {
     // Log the error into the log file if process failed to launch
     misc.writeServerLog('Failed to launch pgAdmin4. Error:');