diff --git a/CHANGES b/CHANGES
index d27d45d88..21175489b 100644
--- a/CHANGES
+++ b/CHANGES
@@ -53,6 +53,11 @@ Deprecated
 Release 1.5.2 (in development)
 ===============================
 
+Incompatible changes
+--------------------
+
+* Dependency requirement updates: requests 2.4.0 or above (refs: #3268, #3310)
+
 Features added
 --------------
 
@@ -73,6 +78,7 @@ Bugs fixed
 * The warning type ``misc.highlighting_failure`` does not work
 * #3294: ``add_latex_package()`` make crashes non-LaTeX builders
 * The caption of table are rendered as invalid HTML (refs: #3287)
+* #3268: Sphinx crashes with requests package from Debian jessie
 
 
 Release 1.5.1 (released Dec 13, 2016)
diff --git a/setup.py b/setup.py
index 051581cc4..ebf810bf8 100644
--- a/setup.py
+++ b/setup.py
@@ -50,7 +50,7 @@ requires = [
     'babel>=1.3,!=2.0',
     'alabaster>=0.7,<0.8',
     'imagesize',
-    'requests',
+    'requests>=2.4.0',
     'typing',
 ]
 extras_require = {
diff --git a/sphinx/util/requests.py b/sphinx/util/requests.py
index d358d8435..3f6ff3879 100644
--- a/sphinx/util/requests.py
+++ b/sphinx/util/requests.py
@@ -17,7 +17,12 @@ import pkg_resources
 
 from six import string_types
 from six.moves.urllib.parse import urlsplit
-from requests.packages.urllib3.exceptions import SSLError, InsecureRequestWarning
+try:
+    from requests.packages.urllib3.exceptions import SSLError, InsecureRequestWarning
+except ImportError:
+    # python-requests package in Debian jessie does not provide ``requests.packages.urllib3``.
+    # So try to import the exceptions from urllib3 package.
+    from urllib3.exceptions import SSLError, InsecureRequestWarning
 
 # try to load requests[security]
 try:
diff --git a/tox.ini b/tox.ini
index 6bcfc42eb..ae802644b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -4,7 +4,7 @@ envlist=flake8,py27,py34,py35,py36,pypy,du13,du12,du11
 [testenv]
 deps=
     six
-    nose
+    pytest
     sqlalchemy
     whoosh
     html5lib
@@ -15,7 +15,7 @@ setenv =
     SPHINX_TEST_TEMPDIR = {envdir}/testbuild
     PYTHONDONTWRITEBYTECODE = true
 commands=
-    {envpython} -Wall tests/run.py --ignore-files=test_autodoc_py35 -m '^[tT]est' {posargs}
+    {envpython} -Wall tests/run.py --ignore tests/py35 {posargs}
     sphinx-build -q -W -b html -d {envtmpdir}/doctrees doc {envtmpdir}/html
 
 [testenv:pypy]
@@ -52,5 +52,5 @@ deps=
     typed_ast
     {[testenv]deps}
 commands=
-    {envpython} -Wall tests/run.py -m '^[tT]est' {posargs}
+    {envpython} -Wall tests/run.py {posargs}
     sphinx-build -q -W -b html -d {envtmpdir}/doctrees doc {envtmpdir}/html