diff --git a/CHANGES b/CHANGES
index 15c4f376c..ef26337ab 100644
--- a/CHANGES
+++ b/CHANGES
@@ -42,6 +42,7 @@ Deprecated
 * ``desc_signature['first']``
 * ``sphinx.directives.DescDirective``
 * ``sphinx.domains.std.StandardDomain.add_object()``
+* ``sphinx.domains.python.PyDecoratorMixin``
 * ``sphinx.parsers.Parser.app``
 * ``sphinx.testing.path.Path.text()``
 * ``sphinx.testing.path.Path.bytes()``
diff --git a/doc/extdev/deprecated.rst b/doc/extdev/deprecated.rst
index e98652ed2..cf914a7cd 100644
--- a/doc/extdev/deprecated.rst
+++ b/doc/extdev/deprecated.rst
@@ -41,6 +41,11 @@ The following is a list of deprecated interfaces.
      - 5.0
      - ``sphinx.domains.std.StandardDomain.note_object()``
 
+   * - ``sphinx.domains.python.PyDecoratorMixin``
+     - 3.0
+     - 5.0
+     - N/A
+
    * - ``sphinx.parsers.Parser.app``
      - 3.0
      - 5.0
diff --git a/sphinx/domains/python.py b/sphinx/domains/python.py
index ea8d6bb70..eed7eaaa6 100644
--- a/sphinx/domains/python.py
+++ b/sphinx/domains/python.py
@@ -25,7 +25,7 @@ from sphinx import addnodes
 from sphinx.addnodes import pending_xref, desc_signature
 from sphinx.application import Sphinx
 from sphinx.builders import Builder
-from sphinx.deprecation import RemovedInSphinx40Warning
+from sphinx.deprecation import RemovedInSphinx40Warning, RemovedInSphinx50Warning
 from sphinx.directives import ObjectDescription
 from sphinx.domains import Domain, ObjType, Index, IndexEntry
 from sphinx.environment import BuildEnvironment
@@ -775,6 +775,15 @@ class PyDecoratorMixin:
     Mixin for decorator directives.
     """
     def handle_signature(self, sig: str, signode: desc_signature) -> Tuple[str, str]:
+        for cls in self.__class__.__mro__:
+            if cls.__name__ != 'DirectiveAdapter':
+                warnings.warn('PyDecoratorMixin is deprecated. '
+                              'Please check the implementation of %s' % cls,
+                              RemovedInSphinx50Warning)
+                break
+        else:
+            warnings.warn('PyDecoratorMixin is deprecated', RemovedInSphinx50Warning)
+
         ret = super().handle_signature(sig, signode)  # type: ignore
         signode.insert(0, addnodes.desc_addname('@', '@'))
         return ret