diff --git a/CHANGES b/CHANGES
index a5dc6da15..4c33180a3 100644
--- a/CHANGES
+++ b/CHANGES
@@ -63,6 +63,7 @@ Bugs fixed
 * #7023: autodoc: nested partial functions are not listed
 * #7023: autodoc: partial functions imported from other modules are listed as
   module members without :impoprted-members: option
+* #6889: autodoc: Trailing comma in ``:members::`` option causes cryptic warning
 
 Testing
 --------
diff --git a/sphinx/ext/autodoc/__init__.py b/sphinx/ext/autodoc/__init__.py
index c9eb5207f..e42169684 100644
--- a/sphinx/ext/autodoc/__init__.py
+++ b/sphinx/ext/autodoc/__init__.py
@@ -72,14 +72,14 @@ def members_option(arg: Any) -> Union[object, List[str]]:
     """Used to convert the :members: option to auto directives."""
     if arg is None or arg is True:
         return ALL
-    return [x.strip() for x in arg.split(',')]
+    return [x.strip() for x in arg.split(',') if x.strip()]
 
 
 def members_set_option(arg: Any) -> Union[object, Set[str]]:
     """Used to convert the :members: option to auto directives."""
     if arg is None:
         return ALL
-    return {x.strip() for x in arg.split(',')}
+    return {x.strip() for x in arg.split(',') if x.strip()}
 
 
 SUPPRESS = object()