diff --git a/src/qemu/qemu_driver.c b/src/qemu/qemu_driver.c
index f7433ee9b3..e6efc809bf 100644
--- a/src/qemu/qemu_driver.c
+++ b/src/qemu/qemu_driver.c
@@ -6016,6 +6016,7 @@ qemuDomainPinIOThread(virDomainPtr dom,
 
         virBitmapFree(iothrid->cpumask);
         iothrid->cpumask = cpumask;
+        iothrid->autofill = false;
 
         /* Configure the corresponding cpuset cgroup before set affinity. */
         if (virCgroupHasController(priv->cgroup,
@@ -6072,6 +6073,7 @@ qemuDomainPinIOThread(virDomainPtr dom,
 
         virBitmapFree(iothrid->cpumask);
         iothrid->cpumask = cpumask;
+        iothrid->autofill = false;
 
         ret = virDomainSaveConfig(cfg->configDir, persistentDef);
         goto endjob;