diff --git a/src/qemu/qemu_capabilities.c b/src/qemu/qemu_capabilities.c
index eed27f6878..8294e1b4a8 100644
--- a/src/qemu/qemu_capabilities.c
+++ b/src/qemu/qemu_capabilities.c
@@ -1702,6 +1702,10 @@ bool virQEMUCapsHasPCIMultiBus(virQEMUCapsPtr qemuCaps,
         return false;
     }
 
+    /* S390 supports PCI-multibus. */
+    if (ARCH_IS_S390(def->os.arch))
+        return true;
+
     /* If ARM 'virt' supports PCI, it supports multibus.
      * No extra conditions here for simplicity.
      */