diff --git a/CHANGELOG.md b/CHANGELOG.md
index f876827d9..e726c1d26 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -12,6 +12,7 @@
 - [Backup NG] Support zstd compression for full backups [#3773](https://github.com/vatesfr/xen-orchestra/issues/3773) (PR [#3883](https://github.com/vatesfr/xen-orchestra/pull/3883))
 - [VM] Ability to copy a VM with zstd compression [#3773](https://github.com/vatesfr/xen-orchestra/issues/3773) (PR [#3889](https://github.com/vatesfr/xen-orchestra/pull/3889))
 - [VM & Host] "Pool > Host" breadcrumb at the top of the page (PR [#3898](https://github.com/vatesfr/xen-orchestra/pull/3898))
+- [Hosts] Ability to enable/disable host multipathing [#3659](https://github.com/vatesfr/xen-orchestra/issues/3659) (PR [#3865](https://github.com/vatesfr/xen-orchestra/pull/3865))
 
 ### Bug fixes
 
diff --git a/packages/xo-server/src/xapi-object-to-xo.js b/packages/xo-server/src/xapi-object-to-xo.js
index 86695d9a2..9ec83ee07 100644
--- a/packages/xo-server/src/xapi-object-to-xo.js
+++ b/packages/xo-server/src/xapi-object-to-xo.js
@@ -173,6 +173,7 @@ const TRANSFORMS = {
           total: 0,
         }
       })(),
+      multipathing: obj.multipathing,
       patches: patches || link(obj, 'patches'),
       powerOnMode: obj.power_on_mode,
       power_state: metrics ? (isRunning ? 'Running' : 'Halted') : 'Unknown',
diff --git a/packages/xo-web/src/common/action-button.js b/packages/xo-web/src/common/action-button.js
index d8b3a121c..70d80a561 100644
--- a/packages/xo-web/src/common/action-button.js
+++ b/packages/xo-web/src/common/action-button.js
@@ -67,7 +67,7 @@ export default class ActionButton extends Component {
     const { children, handler, tooltip } = props
 
     let handlerParam
-    if ('handlerParam' in props) {
+    if (props.handlerParam !== undefined) {
       handlerParam = props.handlerParam
     } else {
       let empty = true
diff --git a/packages/xo-web/src/common/intl/messages.js b/packages/xo-web/src/common/intl/messages.js
index 16b3c6fa6..6153ed785 100644
--- a/packages/xo-web/src/common/intl/messages.js
+++ b/packages/xo-web/src/common/intl/messages.js
@@ -21,6 +21,11 @@ const messages = {
   showLogs: 'Show logs',
   noValue: 'None',
   compression: 'Compression',
+  multipathing: 'Multipathing',
+  enableMultipathing: 'Enable multipathing',
+  disableMultipathing: 'Disable multipathing',
+  enableAllHostsMultipathing: 'Enable all hosts multipathing',
+  disableAllHostsMultipathing: 'Disable all hosts multipathing',
 
   // ----- Modals -----
   alertOk: 'OK',
@@ -757,6 +762,9 @@ const messages = {
   hostStatus: 'Status',
   hostBuildNumber: 'Build number',
   hostIscsiName: 'iSCSI name',
+  hostMultipathingSrs: 'Click to see concerned SRs',
+  hostMultipathingWarning:
+    'The host{nHosts, plural, one {} other {s}} will lose the connection to the SRs. Do you want to continue?',
   hostXenServerVersion: 'Version',
   hostStatusEnabled: 'Enabled',
   hostStatusDisabled: 'Disabled',
diff --git a/packages/xo-web/src/common/xo/index.js b/packages/xo-web/src/common/xo/index.js
index eb256f7f7..eb45d8033 100644
--- a/packages/xo-web/src/common/xo/index.js
+++ b/packages/xo-web/src/common/xo/index.js
@@ -589,6 +589,22 @@ export const setPoolMaster = host =>
 export const editHost = (host, props) =>
   _call('host.set', { ...props, id: resolveId(host) })
 
+import MultipathingModalBody from './multipathing-modal' // eslint-disable-line import/first
+export const setHostsMultipathing = ({
+  host,
+  hosts = [host],
+  multipathing,
+}) => {
+  const ids = resolveIds(hosts)
+  return confirm({
+    title: _(multipathing ? 'enableMultipathing' : 'disableMultipathing'),
+    body: <MultipathingModalBody hostIds={ids} />,
+  }).then(
+    () => Promise.all(map(ids, id => editHost(id, { multipathing }))),
+    noop
+  )
+}
+
 export const fetchHostStats = (host, granularity) =>
   _call('host.stats', { host: resolveId(host), granularity })
 
diff --git a/packages/xo-web/src/common/xo/multipathing-modal/index.js b/packages/xo-web/src/common/xo/multipathing-modal/index.js
new file mode 100644
index 000000000..1c6825c4c
--- /dev/null
+++ b/packages/xo-web/src/common/xo/multipathing-modal/index.js
@@ -0,0 +1,53 @@
+import PropTypes from 'prop-types'
+import React, { Component } from 'react'
+
+import _ from '../../intl'
+import Collapse from '../../collapse'
+import { connectStore } from '../../utils'
+import { createGetObjectsOfType, createSelector } from '../../selectors'
+import { Sr } from '../../render-xo-item'
+
+@connectStore(
+  {
+    srIds: createSelector(
+      createGetObjectsOfType('PBD').filter((_, { hostIds }) => pbd =>
+        hostIds.includes(pbd.host)
+      ),
+      pbds => {
+        const srIds = new Set([])
+        for (const id in pbds) {
+          srIds.add(pbds[id].SR)
+        }
+        return [...srIds]
+      }
+    ),
+  },
+  { withRef: true }
+)
+export default class MultipathingModal extends Component {
+  static propTypes = {
+    hostIds: PropTypes.arrayOf(PropTypes.string).isRequired,
+  }
+
+  render() {
+    const { hostIds, srIds } = this.props
+    return (
+      <div>
+        {_('hostMultipathingWarning', {
+          nHosts: hostIds.length,
+        })}
+        <Collapse
+          buttonText={_('hostMultipathingSrs')}
+          size='small'
+          className='mt-1'
+        >
+          {srIds.map(srId => (
+            <div key={srId}>
+              <Sr id={srId} link newTab />
+            </div>
+          ))}
+        </Collapse>
+      </div>
+    )
+  }
+}
diff --git a/packages/xo-web/src/xo-app/host/tab-advanced.js b/packages/xo-web/src/xo-app/host/tab-advanced.js
index 8c4429088..685558c41 100644
--- a/packages/xo-web/src/xo-app/host/tab-advanced.js
+++ b/packages/xo-web/src/xo-app/host/tab-advanced.js
@@ -2,8 +2,9 @@ import _ from 'intl'
 import Component from 'base-component'
 import Copiable from 'copiable'
 import React from 'react'
-import TabButton from 'tab-button'
 import SelectFiles from 'select-files'
+import StateButton from 'state-button'
+import TabButton from 'tab-button'
 import Upgrade from 'xoa-upgrade'
 import { Text } from 'editable'
 import { Toggle } from 'form'
@@ -13,13 +14,14 @@ import { Container, Row, Col } from 'grid'
 import { forEach, map, noop } from 'lodash'
 import { createGetObjectsOfType, createSelector } from 'selectors'
 import {
-  enableHost,
   detachHost,
   disableHost,
+  enableHost,
   forgetHost,
-  setRemoteSyslogHost,
-  restartHost,
   installSupplementalPack,
+  restartHost,
+  setHostsMultipathing,
+  setRemoteSyslogHost,
 } from 'xo'
 
 const ALLOW_INSTALL_SUPP_PACK = process.env.XOA_PLAN > 1
@@ -183,6 +185,22 @@ export default class extends Component {
                   <th>{_('hostIscsiName')}</th>
                   <Copiable tagName='td'>{host.iSCSI_name}</Copiable>
                 </tr>
+                <tr>
+                  <th>{_('multipathing')}</th>
+                  <td>
+                    <StateButton
+                      className='mb-1'
+                      data-host={host}
+                      data-multipathing={!host.multipathing}
+                      disabledLabel={_('stateDisabled')}
+                      disabledTooltip={_('enableMultipathing')}
+                      enabledLabel={_('stateEnabled')}
+                      enabledTooltip={_('disableMultipathing')}
+                      handler={setHostsMultipathing}
+                      state={host.multipathing}
+                    />
+                  </td>
+                </tr>
                 <tr>
                   <th>{_('hostRemoteSyslog')}</th>
                   <td>
diff --git a/packages/xo-web/src/xo-app/pool/tab-advanced.js b/packages/xo-web/src/xo-app/pool/tab-advanced.js
index e7c4ac52b..24ba714a6 100644
--- a/packages/xo-web/src/xo-app/pool/tab-advanced.js
+++ b/packages/xo-web/src/xo-app/pool/tab-advanced.js
@@ -7,14 +7,15 @@ import Component from 'base-component'
 import renderXoItem from 'render-xo-item'
 import SelectFiles from 'select-files'
 import Upgrade from 'xoa-upgrade'
-import { map } from 'lodash'
 import { connectStore } from 'utils'
-import { injectIntl } from 'react-intl'
-import { createGetObjectsOfType } from 'selectors'
-import { Text, XoSelect } from 'editable'
 import { Container, Row, Col } from 'grid'
+import { createGetObjectsOfType, createGroupBy } from 'selectors'
+import { injectIntl } from 'react-intl'
+import { map } from 'lodash'
+import { Text, XoSelect } from 'editable'
 import {
   installSupplementalPackOnAllHosts,
+  setHostsMultipathing,
   setPoolMaster,
   setRemoteSyslogHost,
   setRemoteSyslogHosts,
@@ -47,13 +48,19 @@ class PoolMaster extends Component {
 }
 
 @injectIntl
-@connectStore({
-  hosts: createGetObjectsOfType('host')
+@connectStore(() => {
+  const getHosts = createGetObjectsOfType('host')
     .filter((_, { pool }) => ({ $pool: pool.id }))
-    .sort(),
-  gpuGroups: createGetObjectsOfType('gpuGroup')
-    .filter((_, { pool }) => ({ $pool: pool.id }))
-    .sort(),
+    .sort()
+  return {
+    hosts: getHosts,
+    hostsByMultipathing: createGroupBy(getHosts, () => ({ multipathing }) =>
+      multipathing ? 'enabled' : 'disabled'
+    ),
+    gpuGroups: createGetObjectsOfType('gpuGroup')
+      .filter((_, { pool }) => ({ $pool: pool.id }))
+      .sort(),
+  }
 })
 export default class TabAdvanced extends Component {
   _setRemoteSyslogHosts = () =>
@@ -62,9 +69,13 @@ export default class TabAdvanced extends Component {
     )
 
   render() {
-    const { hosts, gpuGroups, pool } = this.props
+    const { hosts, gpuGroups, pool, hostsByMultipathing } = this.props
     const { state } = this
     const { editRemoteSyslog } = state
+    const {
+      enabled: hostsEnabledMultipathing,
+      disabled: hostsDisabledMultipathing,
+    } = hostsByMultipathing
     return (
       <div>
         <Container>
@@ -159,6 +170,29 @@ export default class TabAdvanced extends Component {
             </Col>
           </Row>
         </Container>
+        <h3 className='mt-1 mb-1'>{_('multipathing')}</h3>
+        <div>
+          <ActionButton
+            btnStyle='success'
+            data-hosts={hostsDisabledMultipathing}
+            data-multipathing
+            disabled={hostsDisabledMultipathing === undefined}
+            handler={setHostsMultipathing}
+            icon='host'
+          >
+            {_('enableAllHostsMultipathing')}
+          </ActionButton>{' '}
+          <ActionButton
+            btnStyle='danger'
+            data-hosts={hostsEnabledMultipathing}
+            data-multipathing={false}
+            disabled={hostsEnabledMultipathing === undefined}
+            handler={setHostsMultipathing}
+            icon='host'
+          >
+            {_('disableAllHostsMultipathing')}
+          </ActionButton>
+        </div>
         <h3 className='mt-1 mb-1'>{_('supplementalPackPoolNew')}</h3>
         <Upgrade place='poolSupplementalPacks' required={2}>
           <SelectFiles