diff --git a/opm/simulators/flow/Main.cpp b/opm/simulators/flow/Main.cpp
index 963fee78b..91864fba9 100644
--- a/opm/simulators/flow/Main.cpp
+++ b/opm/simulators/flow/Main.cpp
@@ -36,6 +36,7 @@
 #endif
 
 #if HAVE_HYPRE
+#include <HYPRE_config.h>
 #include <HYPRE_utilities.h>
 #endif
 
@@ -173,7 +174,11 @@ void Main::initMPI()
 #endif // HAVE_MPI
 
 #if HAVE_HYPRE
+#if HYPRE_RELEASE_NUMBER >= 22900
     HYPRE_Initialize();
+#else
+    HYPRE_Init();
+#endif
 #endif
 }
 
diff --git a/opm/simulators/linalg/HyprePreconditioner.hpp b/opm/simulators/linalg/HyprePreconditioner.hpp
index c773fd6ab..9539967c7 100644
--- a/opm/simulators/linalg/HyprePreconditioner.hpp
+++ b/opm/simulators/linalg/HyprePreconditioner.hpp
@@ -56,6 +56,7 @@ public:
         use_gpu_ = prm_.get<bool>("use_gpu", false);
 
         // Set memory location and execution policy
+#if HYPRE_USING_CUDA || HYPRE_USING_HIP
         if (use_gpu_) {
             HYPRE_SetMemoryLocation(HYPRE_MEMORY_DEVICE);
             HYPRE_SetExecutionPolicy(HYPRE_EXEC_DEVICE);
@@ -66,7 +67,9 @@ public:
             HYPRE_DeviceInitialize();
             HYPRE_PrintDeviceInfo();
         }
-        else {
+        else
+#endif
+        {
             HYPRE_SetMemoryLocation(HYPRE_MEMORY_HOST);
             HYPRE_SetExecutionPolicy(HYPRE_EXEC_HOST);
         }
diff --git a/opm/simulators/linalg/PreconditionerFactory_impl.hpp b/opm/simulators/linalg/PreconditionerFactory_impl.hpp
index 2d7607a3a..04bedf0e2 100644
--- a/opm/simulators/linalg/PreconditionerFactory_impl.hpp
+++ b/opm/simulators/linalg/PreconditionerFactory_impl.hpp
@@ -549,7 +549,8 @@ struct StandardPreconditioners<Operator, Dune::Amg::SequentialInformation> {
             });
 #if HAVE_HYPRE
             // Only add Hypre for scalar matrices
-            if constexpr (M::block_type::rows == 1 && M::block_type::cols == 1) {
+            if constexpr (M::block_type::rows == 1 && M::block_type::cols == 1 &&
+                          std::is_same_v<HYPRE_Real, typename V::field_type>) {
                 F::addCreator("hypre", [](const O& op, const P& prm, const std::function<V()>&, std::size_t) {
                     return std::make_shared<Hypre::HyprePreconditioner<M, V, V>>(op.getmat(), prm);
                 });