diff --git a/CMakeLists.txt b/CMakeLists.txt
index ef08ba5190..b2e015b12d 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -525,6 +525,10 @@ if(MPI_FOUND)
   include (${CMAKE_CURRENT_SOURCE_DIR}/parallelUnitTests.cmake)
 endif()
 
+if(OPM_ENABLE_PYTHON)
+  include (${CMAKE_CURRENT_SOURCE_DIR}/pythonIntegrationTests.cmake)
+endif()
+
 include(OpmBashCompletion)
 
 if (NOT BUILD_FLOW)
diff --git a/pythonIntegrationTests.cmake b/pythonIntegrationTests.cmake
new file mode 100644
index 0000000000..40d259e2e8
--- /dev/null
+++ b/pythonIntegrationTests.cmake
@@ -0,0 +1,20 @@
+file(MAKE_DIRECTORY ${PROJECT_BINARY_DIR}/tests/integration/HybridNewton)
+
+add_test(NAME
+          HybridNewton
+         COMMAND
+          pytest ${PROJECT_SOURCE_DIR}/python/integration_tests/ml/hybrid_newton
+        WORKING_DIRECTORY
+          ${PROJECT_BINARY_DIR}/tests/integration/HybridNewton
+  )
+if(CMAKE_VERSION VERSION_GREATER_EQUAL 3.22)
+  set(modifications
+      "PYTHONPATH=path_list_append:${opm-common_DIR}/python"
+      "PYTHONPATH=path_list_append:${CMAKE_CURRENT_BINARY_DIR}/python"
+      "FLOW_BINARY=set:$<TARGET_FILE:flow>"
+  )
+  set_tests_properties(HybridNewton PROPERTIES
+                       ENVIRONMENT_MODIFICATION
+                         "${modifications}"
+  )
+endif()