diff --git a/python/Dockerfile b/python/Dockerfile
new file mode 100644
index 000000000..c10788e0e
--- /dev/null
+++ b/python/Dockerfile
@@ -0,0 +1,18 @@
+# Dockerfile to generate PyPI packages. Needs to be run from the opm-common root folder
+# Example use:
+# sudo docker build -t manylinux2014_opm:built . -f python/Dockerfile
+
+FROM quay.io/pypa/manylinux_2_28_x86_64 AS stage1
+ARG version_tag=""
+ARG build_jobs=4
+WORKDIR /tmp/opm
+RUN echo "Using package version tag: $version_tag"
+ADD . .
+RUN /bin/bash setup-docker-image.sh
+FROM stage1 AS stage2
+RUN /bin/bash build-deps.sh $build_jobs
+FROM stage2 AS stage3
+RUN /bin/bash generate-pypi-package.sh $version_tag $build_jobs
+
+FROM scratch AS export_stage
+COPY --from=stage3 /tmp/opm/wheelhouse .
diff --git a/python/MANIFEST.in b/python/MANIFEST.in
new file mode 100644
index 000000000..b02c5e86a
--- /dev/null
+++ b/python/MANIFEST.in
@@ -0,0 +1,2 @@
+include opm/simulators/__init__.py
+include opm/simulators/*.so
diff --git a/python/build-deps.sh b/python/build-deps.sh
new file mode 100755
index 000000000..065880eca
--- /dev/null
+++ b/python/build-deps.sh
@@ -0,0 +1,83 @@
+#!/bin/bash
+
+set -e
+
+BUILD_JOBS=$1
+
+export CMAKE_GENERATOR=Ninja
+
+pushd /tmp/opm
+
+# Build boost
+git clone --depth 1 --branch boost-1.84.0 https://github.com/boostorg/boost
+pushd boost
+git submodule init
+git submodule update
+mkdir build
+cd build
+cmake .. -DCMAKE_BUILD_TYPE=Release -DBUILD_SHARED_LIBS=0 -DCMAKE_POSITION_INDEPENDENT_CODE=1
+cmake --build . -- -j${BUILD_JOBS}
+cmake --build . --target install
+popd
+
+# Build dune-common
+git clone --depth 1 --branch releases/opm/2024.04 https://gitlab.dune-project.org/core/dune-common.git
+pushd dune-common
+mkdir build
+cd build
+cmake .. -DCMAKE_BUILD_TYPE=Release -DBUILD_SHARED_LIBS=0 -DCMAKE_POSITION_INDEPENDENT_CODE=1 -DDUNE_ENABLE_PYTHONBINDINGS=0 -DBLA_STATIC=1 -DCMAKE_DISABLE_FIND_PACKAGE_QuadMath=1 -DBLAS_LIBRARIES=/usr/lib64/libblas.a -DLAPACK_LIBRARIES=/usr/lib64/liblapack.a
+cmake --build . -- -j${BUILD_JOBS}
+cmake --build . --target install
+popd
+
+# Build dune-geometry
+git clone --depth 1 --branch v2.9.1 https://gitlab.dune-project.org/core/dune-geometry.git
+pushd dune-geometry
+mkdir build
+cd build
+cmake .. -DCMAKE_BUILD_TYPE=Release -DBUILD_SHARED_LIBS=0 -DCMAKE_POSITION_INDEPENDENT_CODE=1 -DDUNE_ENABLE_PYTHONBINDINGS=0 -DBLA_STATIC=1 -DCMAKE_DISABLE_FIND_PACKAGE_QuadMath=1  -DBLAS_LIBRARIES=/usr/lib64/libblas.a -DLAPACK_LIBRARIES=/usr/lib64/liblapack.a
+cmake --build . -- -j${BUILD_JOBS}
+cmake --build . --target install
+popd
+
+# Build dune-istl
+git clone --depth 1 --branch releases/opm/2024.04 https://gitlab.dune-project.org/core/dune-istl.git
+pushd dune-istl
+mkdir build
+cd build
+cmake .. -DCMAKE_BUILD_TYPE=Release -DBUILD_SHARED_LIBS=0 -DCMAKE_POSITION_INDEPENDENT_CODE=1 -DDUNE_ENABLE_PYTHONBINDINGS=0 -DBLA_STATIC=1 -DCMAKE_DISABLE_FIND_PACKAGE_QuadMath=1  -DBLAS_LIBRARIES=/usr/lib64/libblas.a -DLAPACK_LIBRARIES=/usr/lib64/liblapack.a
+cmake --build . -- -j${BUILD_JOBS}
+cmake --build . --target install
+popd
+
+# Build dune-uggrid
+git clone --depth 1 --branch v2.9.1 https://gitlab.dune-project.org/staging/dune-uggrid.git
+pushd dune-uggrid
+mkdir build
+cd build
+cmake .. -DCMAKE_BUILD_TYPE=Release -DBUILD_SHARED_LIBS=0 -DCMAKE_POSITION_INDEPENDENT_CODE=1 -DDUNE_ENABLE_PYTHONBINDINGS=0 -DBLA_STATIC=1 -DCMAKE_DISABLE_FIND_PACKAGE_QuadMath=1  -DBLAS_LIBRARIES=/usr/lib64/libblas.a -DLAPACK_LIBRARIES=/usr/lib64/liblapack.a
+cmake --build . -- -j${BUILD_JOBS}
+cmake --build . --target install
+popd
+
+# Build dune-grid
+git clone --depth 1 --branch v2.9.1 https://gitlab.dune-project.org/core/dune-grid.git
+pushd dune-grid
+mkdir build
+cd build
+cmake .. -DCMAKE_BUILD_TYPE=Release -DBUILD_SHARED_LIBS=0 -DCMAKE_POSITION_INDEPENDENT_CODE=1 -DDUNE_ENABLE_PYTHONBINDINGS=0 -DBLA_STATIC=1 -DCMAKE_DISABLE_FIND_PACKAGE_QuadMath=1  -DBLAS_LIBRARIES=/usr/lib64/libblas.a -DLAPACK_LIBRARIES=/usr/lib64/liblapack.a
+cmake --build . -- -j${BUILD_JOBS}
+cmake --build . --target install
+popd
+
+# Build dune-localfunctions
+git clone --depth 1 --branch v2.9.1 https://gitlab.dune-project.org/core/dune-localfunctions.git
+pushd dune-localfunctions
+mkdir build
+cd build
+cmake .. -DCMAKE_BUILD_TYPE=Release -DBUILD_SHARED_LIBS=0 -DCMAKE_POSITION_INDEPENDENT_CODE=1 -DDUNE_ENABLE_PYTHONBINDINGS=0 -DBLA_STATIC=1 -DCMAKE_DISABLE_FIND_PACKAGE_QuadMath=1  -DBLAS_LIBRARIES=/usr/lib64/libblas.a -DLAPACK_LIBRARIES=/usr/lib64/liblapack.a
+cmake --build . -- -j${BUILD_JOBS}
+cmake --build . --target install
+popd
+
+popd
diff --git a/python/generate-pypi-package.sh b/python/generate-pypi-package.sh
new file mode 100755
index 000000000..d504a07fb
--- /dev/null
+++ b/python/generate-pypi-package.sh
@@ -0,0 +1,76 @@
+#!/bin/bash
+
+set -e
+
+VERSION_TAG=${1:-""}
+BUILD_JOBS=$2
+
+export CMAKE_GENERATOR=Ninja
+
+declare -A python_versions
+python_versions[cp36-cp36m]=/opt/python/cp36-cp36m/bin/python
+python_versions[cp37-cp37m]=/opt/python/cp37-cp37m/bin/python
+python_versions[cp38-cp38]=/opt/python/cp38-cp38/bin/python
+python_versions[cp39-cp39]=/opt/python/cp39-cp39/bin/python
+python_versions[cp310-cp310]=/opt/python/cp310-cp310/bin/python
+python_versions[cp311-cp311]=/opt/python/cp311-cp311/bin/python
+python_versions[cp312-cp312]=/opt/python/cp312-cp312/bin/python
+
+for python_bin in ${python_versions[*]}
+do
+  ${python_bin} -m pip install pip --upgrade
+  ${python_bin} -m pip install wheel setuptools twine pytest-runner auditwheel scikit-build cmake
+done
+
+DIR=`pwd`
+
+# Setup opm modules
+git clone https://github.com/OPM/opm-common
+git clone https://github.com/OPM/opm-grid
+git clone https://github.com/OPM/opm-models
+git clone https://github.com/OPM/opm-simulators
+git clone https://github.com/OPM/opm-utilities
+
+ln -sf opm-utilities/opm-super/CMakeLists.txt CMakeLists.txt
+sed -e 's/add_subdirectory(opm-upscaling)//' -e 's/add_dependencies(opmupscaling opmgrid)//g' -i CMakeLists.txt
+
+mkdir -p /tmp/opm/wheelhouse
+
+for tag in ${!python_versions[@]}
+do
+    # Build opm-common bindings
+    pushd opm-common
+    # Delete the folder if it already exists
+    if [ -d $tag ]; then
+      rm -rf $tag
+    fi
+    mkdir $tag && cd $tag
+    cmake -DPYTHON_EXECUTABLE=${python_versions[$tag]} -DWITH_NATIVE=0 \
+      -DOPM_ENABLE_PYTHON=ON -DOPM_PYTHON_PACKAGE_VERSION_TAG=${VERSION_TAG} ..
+
+    # make step is necessary until the generated ParserKeywords/*.hpp are generated in the Python step
+    cmake --build . --target opmcommon_python -- -j${BUILD_JOBS}
+    cd python
+    echo -e "include opm/*\ninclude opm/io/summary/__init__.py" > MANIFEST.in
+    cat MANIFEST.in
+    ${python_versions[$tag]} setup.py sdist bdist_wheel --plat-name manylinux_2_28_x86_64 --python-tag $tag
+    ${python_versions[$tag]} -m auditwheel repair dist/*$tag*.whl
+    cp dist/*$tag*.whl /tmp/opm/wheelhouse
+    popd
+
+    # Delete the folder if it already exists
+    if [ -d $tag ]; then
+      rm -rf $tag
+    fi
+    mkdir $tag && pushd $tag
+    cmake -DPYTHON_EXECUTABLE=${python_versions[$tag]} -DWITH_NATIVE=0 -DBoost_USE_STATIC_LIBS=1 \
+    -DOPM_ENABLE_PYTHON=ON -DOPM_PYTHON_PACKAGE_VERSION_TAG=${VERSION_TAG} -DBLA_STATIC=1 -DBLAS_LIBRARIES=/usr/lib64/libblas.a -DSUITESPARSE_USE_STATIC=1 -DCMAKE_DISABLE_FIND_PACKAGE_QuadMath=1 ..
+
+    # make step is necessary until the generated ParserKeywords/*.hpp are generated in the Python step
+    cmake --build . --target simulators -- -j${BUILD_JOBS}
+    cd opm-simulators/python
+    ${python_versions[$tag]} setup.py sdist bdist_wheel --plat-name manylinux_2_28_x86_64 --python-tag $tag
+    ${python_versions[$tag]} -m auditwheel repair dist/*$tag*.whl
+    cp dist/*$tag*.whl /tmp/opm/wheelhouse
+    popd
+done
diff --git a/python/opm/CMakeLists.txt b/python/opm/CMakeLists.txt
new file mode 100644
index 000000000..dc2c0731e
--- /dev/null
+++ b/python/opm/CMakeLists.txt
@@ -0,0 +1,5 @@
+project(install_python_binding)
+
+cmake_minimum_required(VERSION 3.15)
+
+install(CODE "message(\"Dummy install\")")
diff --git a/python/pyproject.toml b/python/pyproject.toml
new file mode 100644
index 000000000..46a1b880b
--- /dev/null
+++ b/python/pyproject.toml
@@ -0,0 +1,7 @@
+[build-system]
+requires= [
+  "setuptools>=42",
+  "scikit-build>=0.13",
+  "cmake>=3.15",
+  "ninja"
+]
diff --git a/python/requirements.txt b/python/requirements.txt
new file mode 100644
index 000000000..d1a267f64
--- /dev/null
+++ b/python/requirements.txt
@@ -0,0 +1,5 @@
+six
+future
+decorator
+opm
+numpy
diff --git a/python/setup-docker-image.sh b/python/setup-docker-image.sh
new file mode 100755
index 000000000..ed393b619
--- /dev/null
+++ b/python/setup-docker-image.sh
@@ -0,0 +1,11 @@
+#!/bin/bash
+
+# Script to be run on a manylinux2014 docker image to complete it for OPM usage.
+# i.e. docker run -i -t quay.io/pypa/manylinux2014_x86_64 < setup-docker-image.sh
+
+# A ready made Docker image is available at Dockerhub:
+# docker run -i -t lindkvis/manylinux2014_opm:latest
+
+dnf install -y almalinux-release-devel
+
+dnf install -y blas-static lapack-static suitesparse-static ninja-build
diff --git a/python/setup.py.in b/python/setup.py.in
new file mode 100644
index 000000000..371212e7c
--- /dev/null
+++ b/python/setup.py.in
@@ -0,0 +1,39 @@
+from skbuild import setup
+
+import os
+
+setupdir = os.path.dirname(__file__)
+if setupdir != '':
+  os.chdir( setupdir )
+
+with open("README.md", "r") as fh:
+    long_description = fh.read()
+
+with open("requirements.txt", "r") as fh:
+    requires = [line.rstrip() for line in fh]
+
+setup(
+    name='opm-simulators',
+    version = '@opm-simulators_VERSION@' + '@opm-simulators_PYTHON_PACKAGE_VERSION@',
+    url='http://www.opm-project.org',
+    author='The Open Porous Media Project',
+    author_email='opmuser@gmail.com',
+    description='OPM-Simulators Python bindings',
+    long_description=long_description,
+    long_description_content_type="text/markdown",
+    packages=[
+                'opm',
+                'opm.simulators'
+            ],
+    package_data={'opm' : ['$<TARGET_FILE_NAME:simulators>']},
+    include_package_data=True,
+    license='Open Source',
+    test_suite='tests',
+    setup_requires=["pytest-runner", 'setuptools_scm'],
+    install_requires=requires,
+    python_requires='>=3.6',
+    classifiers=[
+        "Programming Language :: Python :: 3",
+        "License :: OSI Approved :: GNU General Public License v3 (GPLv3)",
+    ],
+)
diff --git a/python/simulators/CMakeLists.txt b/python/simulators/CMakeLists.txt
index 76bac1c87..ab65e2d95 100644
--- a/python/simulators/CMakeLists.txt
+++ b/python/simulators/CMakeLists.txt
@@ -91,6 +91,18 @@ add_custom_target(copy_python ALL
         ${PROJECT_SOURCE_DIR}/python/test_data ${PROJECT_BINARY_DIR}/python 0
 )
 
+file(COPY ${PROJECT_SOURCE_DIR}/python/opm/CMakeLists.txt DESTINATION ${PROJECT_BINARY_DIR}/python)
+file(COPY ${PROJECT_SOURCE_DIR}/python/requirements.txt DESTINATION ${PROJECT_BINARY_DIR}/python)
+file(COPY ${PROJECT_SOURCE_DIR}/python/README.md DESTINATION ${PROJECT_BINARY_DIR}/python)
+file(COPY ${PROJECT_SOURCE_DIR}/python/MANIFEST.in DESTINATION ${PROJECT_BINARY_DIR}/python)
+file(COPY ${PROJECT_SOURCE_DIR}/python/pyproject.toml DESTINATION ${PROJECT_BINARY_DIR}/python)
+
+# Generate versioned setup.py
+configure_file(${PROJECT_SOURCE_DIR}/python/setup.py.in
+                ${PROJECT_BINARY_DIR}/python/setup.py.tmp @ONLY)
+file(GENERATE OUTPUT ${PROJECT_BINARY_DIR}/python/setup.py
+               INPUT ${PROJECT_BINARY_DIR}/python/setup.py.tmp)
+
 # Since the installation of Python code is nonstandard it is protected by an
 # extra cmake switch, OPM_INSTALL_PYTHON. If you prefer you can still invoke
 # setup.py install manually - optionally with the generated script